Molecular Diversity - Selectively inhibiting butyrylcholinesterase (BChE) is hypothesized to help in the management of Alzheimer’s disease (AD). Several studies have determined a correlation... 相似文献
(?)‐Cannabidiol ((?)‐CBD), a non‐psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti‐epileptic, anti‐inflammatory, anxiolytic, and anti‐cancer properties. (?)‐CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction‐based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical‐synthetic strategies for (?)‐CBD could tackle these issues, and, additionally, generate novel (?)‐CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (?)‐CBD and its analogs. 相似文献
High reliance on crude oil for energy consumption results in the urgent need to explore and develop alternative renewable sources. One of the most promising routes is the transformation of biomass into biofuels and chemicals. The introduction of deep eutectic solvents in 2004 received a considerable amount of attention across different research fields, particularly in biomass processing. The effectiveness of deep eutectic solvents in breaking down the recalcitrant structure in biomass highlights its impact on the transformation of biomass into various value-added products. In addition, deep eutectic solvents are widely regarded as promising “green” solvents due to their low cost, low toxicity, and biodegradable properties. In this paper, some background information on lignocellulosic biomass and deep eutectic solvents is given. Furthermore, the roles of deep eutectic solvents in biomass processing are discussed, focusing on the impacts of deep eutectic solvents on the selectivity of chemical processes and dissolution of biomass. This review also highlights the advantages and limitations of deep eutectic solvents associated with their usage in biomass valorization. 相似文献
This paper presents reduced-order nonlinear filtering schemes based on a theoretical framework that combines stochastic dimensional reduction and nonlinear filtering. Here, dimensional reduction is achieved for estimating the slow-scale process in a multiscale environment by constructing a filter using stochastic averaging results. The nonlinear filter is approximated numerically using the ensemble Kalman filter and particle filter. The particle filter is further adapted to the complexities of inherently chaotic signals. In particle filters, an ensemble of particles is used to represent the distribution of the state of the hidden signal. The ensemble is updated using observation data to obtain the best representation of the conditional density of the true state variables given observations. Particle methods suffer from the “curse of dimensionality,” an issue of particle degeneracy within a sample, which increases exponentially with system dimension. Hence, particle filtering in high dimensions can benefit from some form of dimensional reduction. A control is superimposed on particle dynamics to drive particles to locations most representative of observations, in other words, to construct a better prior density. The control is determined by solving a classical stochastic optimization problem and implemented in the particle filter using importance sampling techniques.
With the aim of improving the field-effect mobilities in poly(3-hexylthiophene) (P3HT) thin film transistors, we controlled the nanostructures of P3HT thin film by changing the solvent vapor pressure in a spin-coating chamber during solidification. The transistors with P3HT thin films spin-coated under a high solvent vapor pressure (56.5 KPa), showing the one-dimensional nanowire morphologies, resulted in the relatively high field-effect mobilities (0.02 cm2/(V.s)) that are typically more than 1 order of magnitude higher than those prepared under ambient conditions, showing the featureless morphologies. This can be attributed to the higher solvent vapor pressure during film formation, providing the solvent is allowed to evaporate slowly and the degree of ordering within the P3HT crystalline domains is dramatically improved. 相似文献