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491.
David A. Evans Percy H. Carter Erick M. Carreira Joëlle A. Prunet Andr B. Charette Mark Lautens 《Angewandte Chemie (International ed. in English)》1998,37(17):2354-2359
The potent bryostatin antitumor agents are currently in phase II clinical trials for the treatment of a variety of forms of cancer. Aldol reactions and directed reductions are among the essential steps for the formation of fragments A – C in the total synthesis of the title compound. Coupling of these fragments by sulfone-based olefination and alkylation reactions was followed by macrocyclization and introduction of the enoate moieties on rings B and C . 相似文献
492.
Virginie Xavier Tiane C. Finimundy Sandrina A. Heleno Joana S. Amaral Ricardo C. Calhelha Josiana Vaz Tnia C. S. P. Pires Irene Mediavilla Luis Saúl Esteban Isabel C. F. R. Ferreira Lillian Barros 《Molecules (Basel, Switzerland)》2021,26(24)
Cupressus sempervirens L., Juniperus communis L. and Cistus ladanifer L. are Mediterranean arboreal and shrub species that possess essential oils (EO) in their leaves and branches. This study aimed at characterizing the EOs obtained by steam distillation from the three species collected in different locations from Spain (Almazán, Andévalo, Barriomartín, Cerezal, Ermitas and Huéscar). For this purpose, volatiles composition was determined by GC-MS, and different bioactivities were evaluated. The highest content in terpenes was observed in C. sempervirens (Huéscar origin) followed by J. communis (Almazán origin), corresponding to 92% and 91.9% of total compounds, respectively. With exception of C. ladanifer from Cerezal that presented viridiflorol as the most abundant compound, all the three species presented in common the α-pinene as the major compound. The EOs from C. ladanifer showed high antibacterial potential, presenting MIC values from 0.3 to 1.25 mg/mL. Concerning other bioactivities, C. ladanifer EO revealed an oxidation inhibition of 83%, while J. communis showed cytotoxicity in the MCF-7 cell line, and C. sempervirens and C. ladanifer EOs exhibited the highest potential on NCI-H460 cell lines. Nevertheless, some EOs revealed toxicity against non-tumoral cells but generally presented a GI50 value higher than that of the tumor cell lines. 相似文献
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Summary: A conjugated polymer ( P1 ) containing a pendant aldehyde was anodically prepared on ITO electrodes. Aminothiophenes could be captured by reacting with an aldehyde group located along the polymer backbone resulting in a robust azomethine bond. This was confirmed both spectroscopically and electrochromically. P1 undergoes absorbance and fluorescence bathochromic shifts when an aminothiophene is covalently linked to the aldehyde resulting from azomethine formation. Both the absorbance and fluorescence shifts are dependent on the aminothiophene used to form the azomethine bond. 相似文献
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