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排序方式: 共有586条查询结果,搜索用时 46 毫秒
101.
Dr. Tatsuki Kurokawa Dr. Shigeki Kiyonaka Dr. Eiji Nakata Dr. Masayuki Endo Shohei Koyama Emiko Mori Nam Ha Tran Huyen Dinh Dr. Yuki Suzuki Kumi Hidaka Dr. Masaaki Kawata Dr. Chikara Sato Prof. Hiroshi Sugiyama Prof. Takashi Morii Prof. Yasuo Mori 《Angewandte Chemie (International ed. in English)》2018,57(10):2586-2591
In native systems, scaffolding proteins play important roles in assembling proteins into complexes to transduce signals. This concept is yet to be applied to the assembly of functional transmembrane protein complexes in artificial systems. To address this issue, DNA origami has the potential to serve as scaffolds that arrange proteins at specific positions in complexes. Herein, we report that Kir3 K+ channel proteins are assembled through zinc‐finger protein (ZFP)‐adaptors at specific locations on DNA origami scaffolds. Specific binding of the ZFP‐fused Kir3 channels and ZFP‐based adaptors on DNA origami were confirmed by atomic force microscopy and gel electrophoresis. Furthermore, the DNA origami with ZFP binding sites nearly tripled the K+ channel current activity elicited by heterotetrameric Kir3 channels in HEK293T cells. Thus, our method provides a useful template to control the oligomerization states of membrane protein complexes in vitro and in living cells. 相似文献
102.
Bagrat A. Shainyan Elena N. Suslova Tran Dinh Phien Sergey A. Shlykov Erich Kleinpeter 《Tetrahedron》2018,74(32):4299-4307
1-(Dimethylamino)-1-phenyl-1-silacyclohexane 1, was synthesized, and its molecular structure and conformational properties studied by gas-phase electron diffraction (GED), low temperature 13C NMR spectroscopy and quantum-chemical calculations. The predominance of the 1-Phax conformer (1-Pheq:1-Phax ratio of 20:80%, ΔG°(317?K)?=??0.87?kcal/mol) in the gas phase is close to the theoretically estimated conformational equilibrium. In solution, low temperature NMR spectroscopy showed analyzable decoalescence of Cipso and C(1,5) carbon signals in 13C NMR spectra at 103?K. Opposite to the gas state in the freon solution employed (CD2Cl2/CHFCl2/CHFCl2?=?1:1:3), which is still liquid at 100?K, the 1-Pheq conformer was found to be the preferred one [(1-Pheq: 1-Phax?=?77%: 23%, K?=?77/23?=?2.8; ?ΔG°?=??RT ln K (at 103?K)?=?0.44?±?0.1?kcal/mol]. When comparing 1 with 1-phenyl-1-(X)silacylohexanes (X?=?H, Me, OMe, F, Cl), studied so far, the trend of predominance of the Phax conformer in the gas phase and of the Pheq conformer in solution is confirmed. 相似文献
103.
Shon YS Choi D Dare J Dinh T 《Langmuir : the ACS journal of surfaces and colloids》2008,24(13):6924-6931
This article presents a synthesis method for nanoparticle-cored dendrimers (NCDs), which have dendritic architectures around a monolayer-protected gold nanoparticle. The synthesis method is based on a strategy in which the synthesis of monolayer-protected nanoparticles is followed by adding dendrons on functionalized nanoparticles by a single coupling reaction. NMR spectroscopy, IR spectroscopy, and thermogravimetric analysis (TGA) characterizations confirmed the successful coupling reaction between dendrons with different generations ([G1], [G2], and [G3]) and COOH-functionalized nanoparticles ( approximately Au201L71). The dendrimer wedge density also could be controlled by reacting nanoparticles having different loading of COOH groups ( approximately 60 and approximately 10% COOH of the 71 ligands per gold nanoparticle) with functionalized dendrons. Transmission electron microscope results showed that this synthesis strategy maintains the average size of the nanoparticle core during dendron coupling reactions. This control over the composition and core size makes the systematic study of NCDs with different generations possible. The chemical stability of NCDs was found to be affected by dendron generation around the nanoparticle core. The current-potential response of NCD films on microelectrode arrays exhibited better electrical conductivity for NCDs with lower dendron generation. 相似文献
104.
Kiem PV Tri MD Tuong le VD Tung NH Hanh NN Quang TH Cuong NX Minh CV Choi EM Kim YH 《Chemical & pharmaceutical bulletin》2008,56(9):1270-1275
Two new phenyl glycosides, mangliesides A and B (1, 2), a new ionol glycoside, manglieside C (3), two new lignan glycosides, mangliesides D and E (4, 5), were isolated from the leaves of Manglietia phuthoensis, along with two known lignans, 3-methoxymagnolol (6) and obovatol (7). Their structures were established by means of 1D and 2D NMR, electrospray ionization (ESI)-MS and HR-ESI-MS experiments. Among them, compounds 2 and 5 significantly (p<0.05) increased the growth and differentiation of osteoblastic MC3T3-E1 cells in vitro. 相似文献
105.
106.
107.
Truong Minh Duc Dang Huu Dinh Tran Quang Dat 《International Journal of Theoretical Physics》2016,55(6):3027-3040
We examine the higher-order nonclassical properties of the even and odd charge coherent states as well as proposing a scheme to generate these states whose modes can freely travel in open space. We show that the even and odd charge coherent states exhibit both higher-order antibunching and higher-order squeezing. While the two-mode higher-order antibunching occurs in any order and essentially depends on the charge number, the two-mode higher-order squeezing appears only in the even orders. We also prove that these states are genuinely entangled, and they can be generated by means of cross-Kerr media, beam splitters, phase shifts and threshold detectors. We find that the fidelity and the corresponding success probability to generate these states are dependent on the correlative parameters. 相似文献
108.
Luong Thuan Thanh Jacques A Ferland Bouazza Elbenani Nguyen Dinh Thuc Van Hien Nguyen 《The Journal of the Operational Research Society》2016,67(1):20-36
In this paper we solve the 0–1 cell formation problem where the number of cells is fixed a priori and where the objective is to maximize the overall efficiency of a production system by grouping together machines providing service to similar parts into a subsystem (denoted cell). Three different methods are introduced and compared numerically. The first local search method is an implementation of simulated annealing (SA) where the definition of the neighbourhood is specific to the application and requires using a diversification and intensification strategies. The second local search method is an adaptive simulated annealing method where the neighbourhood is selected randomly at each iteration. The procedure is adaptive in the sense that the probability of selecting a neighbourhood is updated during the process. The third method is a hybrid method (HM) of a population-based method and a local search method. To improve the solution obtained with HM, we apply a SA method afterward. The best variants are very efficient to solve the 35 benchmark problems commonly used in the literature. 相似文献
109.
Tien-Cuong Dinh 《Journal of Geometric Analysis》2007,17(2):227-244
Let f be a holomorphic endomorphism of ℙ
k
having an attracting setA. We construct an attracting current and an equilibrium measure associated toA. The attracting current is weakly laminar and extremal in the cone of invariant currents. The equilibrium measure is mixing
and has maximal entropy onA. 相似文献
110.
In this paper, we discuss the uniqueness in determining cavities (i.e., nonrectilinear cracks) in a heterogeneous isotropic
elastic medium in two dimensions. Our main result asserts that there is at most one cavity in the elastic medium which yields
the same surface displacements and stresses on an arbitarily small portion of the boundary. The boundaries of cavities are
assumed to be piecewise smooth and admit edges where no net force is exerted. The key of the proof is the unique continuation
for the isotropic Lamé system and geometric considerations.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献