Structure elucidation and NMR assignments of a new 6,9-cyclotetrahydrofuranlignan from Syringa pinnatifolia

A new 6,9-cyclotetrahydrofuranlignan, 3,3′-dimethoxy-4,4′-dihydroxy-8β,9β,8′α-6,9-cyclotetrahydrofuranlignan, was isolated from the stem of Syringa pinnatifolia Hems1.var. alashanensis MA. et S. Q. ZHOU. Its structures were elucidated on the basis of spectroscopic methods including UV, IR, ESI-MS, 1D NMR and 2D NMR.     

Rhodium‐Catalyzed Oxidative Benzannulation of N‐Pivaloylanilines with Internal Alkynes through Dual C−H Bond Activation: Synthesis of Highly Substituted Naphthalenes

An efficient method was developed for the synthesis of highly substituted naphthalenes through rhodium‐catalyzed oxidative benzannulation of N‐pivaloylanilines with internal alkynes. The benzannulation reaction proceeded smoothly through dual C?H bond activation to produce the corresponding highly substituted naphthalene products in satisfactory to good yields.     

Optimal Control of the Instationary Three Dimensional Navier-Stokes-Voigt Equations

We study an optimal control problem with quadratic objective functional for the three dimensional Navier-Stokes-Voigt equations in bounded domains. We show the existence of optimal solutions, the necessary optimality conditions and the sufficient optimality conditions. The second-order optimality conditions obtained in the article seem to be optimal.     

Blow-up for Stochastic Reaction-Diffusion Equations with Jumps

In this paper, we focus on stochastic reaction-diffusion equations with jumps. By a new auxiliary function, we investigate non-negative property of the local strong (variational) solutions, which applies to stochastic reaction-diffusion equations with highly nonlinear noise terms. As a byproduct, we study the problem of non-existence of global strong solutions by imposing appropriate conditions on the drift terms, which can cover many more models than the existing literature. Moreover, we also investigate the subject of Lévy-type noise-induced explosion by bringing some plausible assumptions to bear on the noise terms, which, however, need not guarantee local strong (variational) solutions to enjoy the non-negative property. Meanwhile, several examples are presented to illustrate the theory established.     

Mn助剂对K-Co-Mo催化剂结构及CO加氢合成低碳醇性能的影响

通过溶胶-凝胶法合成了一系列Mn掺杂K-Co-Mo催化剂,并利用X射线衍射、N₂吸脱附、NH₃程序升温脱附、原位漫反射红外光谱以及X射线吸收谱等技术对催化剂的结构进行了表征.活性测试结果显示Mn掺杂催化剂比未掺杂催化剂表现更高的合成低碳醇的催化活性,尤其是C₂₊醇的选择性得到了明显的提高.醇产物分布偏离了ASF分布规律,甲醇的含量显著减少,乙醇成为主要醇产物.表征结果表明Mn助剂的加入增强了Co和Mo之间的相互作用,促进了醇生成活性中心Co-Mo-O物种的生成.显著减少了催化剂强酸性位的数量,促进了弱酸性位的产生,有利于醇产物的生成.助剂的加入有利于催化剂对CO的线性和桥式吸附,促进了醇产物的生成和碳链的增长,提高了催化剂对C₂₊醇的选择性.     

基于PSO算法的RoboCup2D机器人研究

对机器人体系结构、动作学习及行为的组织方式进行了研究,以演化计算为基本方法,以RoboCup2D为平台,设计了基于PSO算法的足球机器人的体系结构,解决感知、动作、和规划问题;在训练环境下,形成感知规则,优化感知相关参数,得到对信息高效快速的感知方法,并根据指定的粒度、功能、参数,对RoboCup2D机器人的原子动作进行了组合优化,得到一组带参数和执行效果描述的粒子动作;最后在赛场环境和任务驱动下,搜索粒子动作并进行组织规划,得到完成特定任务的机器人行为;RoboCup2D仿真实验表明,演化计算方法不仅能利用原子动作进行组合优化,得到适应于不同条件的粒子动作,而且能通过其在线搜索粒子动作,动态组成机器人行为;基于演化计算的足球机器人能更好地完成跑位、截球、带球、传球等任务,具有更强的适应性。     

北斗B1信号捕获跟踪算法的软件仿真研究

针对北斗B1频率的I支路信号,设计并实现了北斗软件接收机的基带处理部分。阐述了北斗B1频点信号的扩频体制和产生过程,并行码相位搜索捕获策略以及鉴相辅助跟踪环路,并设计了二阶数字环路滤波器,滤波器参数取ζ=0.707,B_n=25(Hz)。同时采用Matlab软件,仿真北斗中频数字信号,编码实现捕获跟踪算法,并分别通过对仿真信号和真实卫星信号的捕获跟踪,验证捕获跟踪算法的可行性,并提出锁频环辅助锁相环算法的改进思路。为进一步开展北斗软件接收机相关技术研究打下了基础。     

Antibacterial thymol derivatives isolated from Centipeda minima

Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.     

Quantifying hydrogen-bonding strength: the measurement of 2hJNN couplings in self-assembled guanosines by solid-state 15N spin-echo MAS NMR

(2h)J(NN) hydrogen-bond mediated J couplings are measured in the solid state for two synthetic deoxyguanosine derivatives by (15)N MAS NMR spin-echo experiments. The use of rotor-synchronised Hahn-echo pulse train (RS-HEPT) (1)H decoupling, with a duty cycle of 6%, allows spin-echo durations out to 200 ms, hence enabling the accurate determination of J couplings as small as 3.8 Hz. A single-crystal X-ray diffraction structure exists for the shorter alkyl chain derivative dG(C(3))(2): the observation of significantly different (2h)J(NN) couplings, 6.2 +/- 0.4 and 7.4 +/- 0.4 Hz, for the two resolved N7 resonances is to be expected given the NH...N hydrogen-bonding distances of 2.91 and 2.83 A for the two distinct molecules in the asymmetric unit cell. For the longer alkyl chain derivative, dG(C(10))(2), for which there is no single-crystal diffraction structure, a (15)N refocused INADEQUATE spectrum (Pham et al., J. Am. Chem. Soc., 2005, 127, 16018-16019) has demonstrated the presence of N2-H...N7 intermolecular hydrogen-bonds indicative of a quartet-like structure. The (2h)J(NN) hydrogen-bond mediated J coupling of 5.9 +/- 0.2 Hz is at the lower end of the range (5.9-8.2 Hz) of (2h)J(NN) couplings determined from solution-state NMR of guanosine quartets in quadruplex DNA. A full discussion of the determination of error bars on the fitted parameters is given; specifically, error bars determined by a non-linear fitting (using the covariance matrix) or in a Monte-Carlo fashion are found to give effectively identical results.     

Enhanced aqueous solubility of long wavelength voltage-sensitive dyes by covalent attachment of polyethylene glycol

Long wavelength voltage-sensitive dyes (VSDs) called Pittsburgh (PGH) dyes were recently synthesized by coupling various heterocyclic groups to a styryl-thiophene intermediate forming extended, partially rigid chromophores. Unlike most styryl VSDs, dyes with a sulfonic acid anchor directly attached to the chromophore showed no solvatochromic absorption shifts. The limited water solubility of many long wavelength VSDs requires the use of surfactants to transport the dye through physiological saline solutions and effectively label biological membranes. Here, we tested the chemical substitution of the sulfonic acid moiety with polyethyleneglycol (PEG) chains, ranging from MW 750 to 5000, to overcome the poor solubility of VSDs while retaining their properties as VSDs. The chemical synthesis of PGH dyes and their PEG derivatives are described. The PEG derivatives were soluble in aqueous solutions (>1 mM) and still reported membrane potential changes. In frog and mouse hearts, the voltage sensitivity (DeltaF/F per action potential) and spectral properties of PEG dyes were the same as the sulfonated analogues. Thus, the solubility of VSDs can be considerably improved with small polyethyleneglycol chains and can provide an effective approach to improve staining of excitable tissues and optical recordings of membrane potential.