A novel near-infrared fluorescent probe was synthesized and its application in imaging of living cells

A novel near-infrared fluorescent probe, IR-736, was synthesized and applied to living cells. The probe exhibited good response fluorescent characteristic, and cells experiments showed the probe had high affinity and without apparent cytotoxicity. Fluorescent image experiments in living L929 cells, MCF-7 cells, HepG2 cells, further demonstrated its potential applications in biological systems. The probe effectively prevented the influence of autofluorescence and native cellular species in biological systems. It also exhibited good photostability, and excellent cell membrane permeability.     

链酚胺型配体合成及其与锌（Ⅱ）离子配位研究

金属酶的模拟研究越来越受到重视，其中锌酶具有数量多、作用范围广等特点［１，２］。在不同功能的金属酶中，活性中心金属离子的几何构型可以发生较大的变化［３］。锌（Ⅱ）离子的ｄ１０电子构型使其配合物不具有晶体场稳定化作用，使其具有更大自由度的配位数选择性以...     

Enhancement of Dielectronic Recombination by External Electromagnetic Fields

The enhancement of the dielectronic recombination rate of lithiumlike Ne⁷⁺ and O⁵⁺ ions by external electromagnetic fields has been measured at the storage ring CRYRING. The energy range covered all 1s ²2pnl dielectronic recombination resonances attached to the 2s→2p core excitation. Electric fields up to 1436 V/cm were applied in the Ne⁷⁺ experiment and the saturation of the enhancement with increasing electric field could clearly be seen. In the O⁵⁺ experiment the enhancement was studied as a function of the Rydberg quantum number n.

     

SU(3)夸克模型中的Ω束缚态

从夸克 -反夸克通过介子场耦合的模型出发研究了 (ΩN) LST是否存在束缚态的问题 .计算表明当考虑了s u(s d)湮没为K 介子的机制后 ,(Ω N)0 2 1 2 是有可能形成结合能较大的束缚态     

BSA Hybrid Synthesized Polymer

Bovine serum albumin （BSA）, a naturally occurring biopolymer, was regarded as a polymeric material to graft to an acrylic acid （AA）-N-vinyl pyrrolidone （NVP） copolymer to form a biomacromolecular hybrid polymer. The hybrid polymer can be blended with polyethersulfone （PES） to increase the hydrophilicity of the PES membrane, which suggested that the hybrid polymer might have a wide application in the modification of biomaterials.     

单纯形上的q-Stancu多项式的最优逼近阶

构造了单纯形上的多元q-Stancu多项式,它是著名的Bernstein多项式和Stancu多项式的推广.建立该类多项式逼近连续函数的上、下界估计,进而给出其对连续函数的最优逼近阶(饱和阶)及其特征刻画.此外,还研究了该类多项式逼近连续函数的饱和类.     

从文献分析看物理学科领域的发展重点

文章从文献分析的角度，首先研究了美国、英国政府确定的物理学重点研究领域；其次利用美国科学情报研究所的科学引文热门论文数据库，分析了世界物理学及其交叉学科的热点、新兴的研究前沿和快速突破的领域；最后，提出了分析总结意见。     

Formation of D- by double radiative recombination of D+

We have investigated double radiative recombination of D⁺ ions stored in CRYRING by searching for the formation of D^- in the electron cooler. An upper limit for the double electron recombination rate coefficient and a ratio of this coefficient over the single electron radiative recombination rate coefficient of (3.8 ± 1.5) × 10^-8 are obtained experimentally. Theoretical calculations of the rates and a discussion in comparison with double photoionization of H^- are given. This revised version was published online in August 2006 with corrections to the Cover Date.     

A novel traceless route to synthesize 3,5-disubstituted-1,2,4-triazoles on PEG6000

A novel traceless route to 3,5-disubstituted-1,2,4-triazoles has been described, which allows the incorporation of two elements of diversity. This method provided a library of 3,5-disubstituted-1,2,4-triazoles with high yields and purity.     

A Novel Aspect of Photodynamic Action: Induction of Recurrent Spikes in Cytosolic Calcium Concentration

Effects of photodynamic action of gadolinium porphyrin-like macrocycle B (PLMGdB) on cytosolic Ca²⁺ concentration, [Ca²⁺]_c, was investigated in isolated rat pancreatic acini. The PLMGdB alone or light alone (2 min) had no effect on [Ca²⁺]_c. Cell-bound PLMGdB upon brief (0.5–2.0 min) light activation triggered recurrent spikes in [Ca²⁺]_c. At lower PLMGdB concentration (100 nM) the spikes continued during the whole period of monitoring [Ca²⁺]_c. At a higher concentration of 500 nM, the spikes continued for the first 40 min, followed by a gradual increase in basal [Ca²⁺]_c upon which smaller spikes were superimposed. At 1, the spikes continued for the first 20 min, after that spiking gradually degenerated into a plateau phase. In many aspects, photodynamically triggered spikes resembled spikes generated by physiological concentrations of cholecystokinin. The spikes triggered by photodynamic action were likely to be the result of the ignition of a physiological “chain reaction”, because functional inositol-1,4,5-trisphosphate (IP₃) receptors were required for spiking to occur. Two-aminoe-thoxydiphenylborate, an inhibitory modulator of IP₃-triggered Ca²⁺ release from intracellular stores, effectively inhibited photodynamically generated spikes. Therefore photodynamic action appears to be able to permanently transfix a physiological process, leading to long-lasting pharmacological or therapeutic effects.