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排序方式: 共有143条查询结果,搜索用时 15 毫秒
141.
142.
S. Dobosz M. Schmidt M. Perdrix P. Meynadier O. Gobert D. Normand K. Ellert T. Blenski A. Ya. Faenov A. I. Magunov T. A. Pikuz I. Yu. Skobelev N. E. Andreev 《Journal of Experimental and Theoretical Physics》1999,88(6):1122-1129
The x-ray spectra of a plasma generated by heating CO2 and Ar clusters with high-intensity femtosecond laser pulses with q
las≃1018 W/cm2 are investigated. Spatially resolved x-ray spectra of a cluster plasma are obtained for the first time. Photoionization absorption
is observed to influence the spectral line profiles. The recorded features of the x-ray emission spectra definitely indicate
the existence of a large relative number of excited ions (≃10−2–10−3) with energies of 0.1–1 MeV in such a plasma. Possible mechanisms underlying the acceleration of ions to high energies are
discussed. It is shown that the experimental results can be attributed to the influence of ponderomotive forces in standing
waves generated by the reflection of laser radiation from the clusters.
Zh. éksp. Teor. Fiz. 115, 2051–2066 (June 1999) 相似文献
143.
Fernando Calzada Normand Garcia-Hernandez Sergio Hidalgo-Figueroa Elihú Bautista Elizabeth Barbosa Claudia Velzquez Marta Elena Hernndez-Caballero 《Molecules (Basel, Switzerland)》2022,27(5)
Heliangolide-type sesquiterpene lactones (HTSLs) are phytocompounds with several pharmacological activities including cytotoxic and antitumor activity. Both bioactivities are related to an α-methylene-γ-lactone moiety and an ester group on carbon C-8 in the sesquiterpene lactone (SL) structure. Two HTSLs, incomptines A (AI) and B (IB) isolated from Decachaeta incompta, were evaluated for their cytotoxic activity on three leukemia cell lines: HL-60, K-562, and REH cells. Both compounds were subjected to a molecular docking study using target proteins associated with cancer such as topoisomerase IIα, topoisomerase IIβ, dihydrofolate reductase, methylenetetrahydrofolate dehydrogenase, and Bcl-2-related protein A1. Results show that IA and IB exhibit cytotoxic activity against all cell lines used. The CC50 value of IA was 2–4-fold less than etoposide and methotrexate, two anticancer drugs used as positive controls. The cytotoxic activity of IB was close to that of etoposide and methotrexate. The molecular docking analysis showed that IA and IB have important interaction on all targets used. These findings suggest that IA and IB may serve as scaffolds for the development of new treatments for different types of leukemia. 相似文献