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This study sets out to examine whether the demand for softwood lumber in the United States is responsive to various market factors including the price of softwood lumber, the price of other building materials, and the level of economic activity (e.g. housing starts). Concern in the analysis is focused on overcoming some of the methodological shortcomings found in previous studies of this issue. The results are conclusive. The quantity of softwood lumber demanded does respond to the various economic factors considered. Moreover, when the structural stability of the estimated relationships is investigated, the results suggest that the demand for softwood lumber regionally in the United States has remained unaltered over the sample period (1950–1985). 相似文献
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Zhongren Wu Maria G Cappiello Boyd B Scott Yuri Bukhtiyarov Gerard M McGeehan 《BMC biochemistry》2008,9(1):19
Background
The renin-angiotensin-aldosterone system (RAS) cascade is a major target for the clinical management of hypertension. Although inhibitors of various components of this cascade have been developed successfully, development of renin inhibitors has proven to be problematic. The development of these inhibitors has been hindered by poor bioavailability and complex synthesis. However, despite the challenges of designing renin inhibitors, the enzyme remains a promising target for the development of novel treatments for hypertension. X-ray crystallographic data could greatly assist the design and development of these inhibitors. Here we describe the purification and characterization of recombinant human renin for x-ray crystallization studies. 相似文献97.
Naomi C. Delic J. Guy Lyons Nick Di Girolamo Gary M. Halliday 《Photochemistry and photobiology》2017,93(4):920-929
The cornea sits at the anterior aspect of the eye and, like the skin, is highly exposed to ultraviolet radiation (UVR). The cornea blocks a significant proportion of UVB from reaching the posterior structures of the eye. However, UVA can penetrate the full thickness of the cornea, even reaching the anterior portion of the lens. Epidemiological data indicate that UVR is a contributing factor for a multitude of diseases of the cornea including pterygium, photokeratitis, climatic droplet keratopathy and ocular surface squamous neoplasia (OSSN), although the pathogenic mechanisms of each require further elucidation. UVR is a well‐known genotoxic agent, and its effects have been well characterized in organs such as the skin. However, we are only beginning to identify its effects on the cornea, such as the UVR signature C → T and CC → TT transversions identified by sequencing and increased proliferative and shedding rates in response to UVR exposure. Alarmingly, a single low‐dose exposure of UVR to the cornea is sufficient to elicit genetic, molecular and cellular changes, supporting the consideration of using protective measures, such as wearing sunglasses when outdoors. The aim of this review was to describe the adverse effects of UVR on the cornea. 相似文献
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Hugo J. Bohórquez Chérif F. Matta Russell J. Boyd 《International journal of quantum chemistry》2010,110(13):2418-2425
The local single particle momentum is proposed as a localized‐electrons detector (LED) that provides a direct three‐dimensional representation of bonding interactions in molecules. It is given exclusively in terms of the electron density and its gradient. We show that the graphical representation of bonding interactions given by LED is consistent with the local curvatures of the electron density as given by the eigenvalues of the Hessian matrix, according to a local symmetry classification of the critical points here introduced. LED consistently complements the topological analysis of the electron density given by the quantum theory of atoms in molecules, by providing a graphical representation of the symmetry of the bonding interactions in molecular systems. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem 110:2418–2425, 2010 相似文献
99.
The absolute configurations of 2-cyclohexenone cis-diol metabolites resulting from the biotransformation of the corresponding phenols have been determined by comparison of their experimental and calculated circular dichroism spectra (TDDFT at the PCM/B2LYP/Aug-cc-pVTZ level), optical rotations (calculated at the PCM/B3LYP/Aug-cc-pVTZ level) and by stereochemical correlation. It is found that circular dichroism spectra and optical rotations of 2-cyclohexenone derivatives are strongly dependent on the ring conformation (M or P sofa S(5) or half-chair), enone non-planarity and the nature and positions of the hydroxy and alkyl substituents. The effect of non-planarity of the enone chromophore, including the distortion of the C=C bond, is determined for the model structures by TDDFT calculations at the PCM/B2LYP/6-311++G(2d,2p) level. Non-planarity of the C=C bond in the enone chromophore is commonly encountered in 2-cyclohexenone derivatives and it is a source of significant rotatory strength contribution to the electronic circular dichroism spectra. It is shown that the two lowest-energy transitions in acrolein and 2-cyclohexenone and its derivatives are n(C=O)-π(C=O)* and π(C=C)-π(C=O)*, as expected, while the shorter-wavelength (below 200 nm) transitions are of more complex nature. In 2-cyclohexenone and its alkyl derivatives it is predominantly a mixture of π(C=C)-π(C=C)* and π(C=C)-σ* transitions, whereas the presence of hydroxy substituent results in a dominant contribution due to the n(OH)-π(C=O)* transition. A generalized model for correlation of the CD spectra of 2-cyclohexenones with their structures is presented. 相似文献
100.
Kudavalli JS Boyd DR Coyne D Keeffe JR Lawlor DA MacCormac AC More O'Ferrall RA Rao SN Sharma ND 《Organic letters》2010,12(23):5550-5553
Benzene-cis- and trans-1,2-dihydrodiols undergo acid-catalyzed dehydration at remarkably different rates: k(cis)/k(trans) = 4500. This is explained by formation of a β-hydroxycarbocation intermediate in different initial conformations, one of which is stabilized by hyperconjugation amplified by an aromatic no-bond resonance structure (HOC(6)H(6)(+) ? HOC(6)H(5) H(+)). MP2 calculations and an unfavorable effect of benzoannelation on benzenium ion stability, implied by pK(R) measurements of -2.3, -8.0, and -11.9 for benzenium, 1-naphthalenium, and 9-phenanthrenium ions, respectively, support the explanation. 相似文献