Synthesis and antiulcer activity of the metabolites of 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate (AS-2646), a novel gastric antisecretory and antiulcer agent

The metabolites 3 and 4 of 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate (AS-2646, 1), a candidate as a gastric antisecretory and antiulcer drug, were synthesized to confirm the proposed structures. The effects of the metabolites 2-4 on ulcer induced by stress were determined.     

A finite element analysis of strain localization for soft rock using a constitutive equation with strain softening

Summary It is well known that deformation and/or strain of geological materials localize when they come close to the failure state. In the present: study, we try to analyze the deformation problem using a constitutive relation with strain hardening and strain softening. The constitutive model of a soft rock and overconsolidated clay using an elasto-plastic constitutive theory with memory was originally developed by Adachi and Oka. This type of formulation is shown to be easily applied to analyze the material behavior of strain softening because there is a similarity to that in viscoplasticity. Using the proposed model, the loss of uniqueness of the solution to the initial value problem can be avoided and a special or complicated numerical technique, e.g., an arc length method, does not need to be used. When we use constitutive equations with strain softening in a finite element analysis, there is a problem of strong mesh size dependency of numerical results. To remedy the mesh size dependency, we generalize the Adachi-Oka model based on the concept of non-localization by Bazant. We apply the proposed constitutive model to the behavior of a sedimentary soft rock in the drained triaxial compression test. It is found that mesh size dependency becomes smaller using the non-localization of the constitutive model.

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Eine Finite-Element-Analyse der lokalisierten Verformung von weichem Gestein bei einem Stoffgesetz mit Entfestigung

Übersicht Bekanntlich findet bei geologischen Stoffen in der Nähe des Versagenszustandes eine Lokalisierung der Verformung statt. Die Analyse dieses Problems wird in diesem Beitrag auf der Grundlage eines Stoffansatzes mit Ver- und Entfestigung unternommen. Entwickelt wurde das zugrunde gelegte elastischplastische Stoffmodell mit Gedächtnis von Adachi und Oka für weiches Gestein und übermäßig verdichteten Ton. Wegen der Ähnlichkeit zur Viskoplastizität läßt sich diese Formulierung des Stoffgesetzes leicht auf die Analyse des Verhaltens von entfestigendem Material anwenden, da der Eindeutigkeitsverlust der Lösung des Anfangswertproblems vermieden wird und besondere Rechenverfahren wie etwa die Bogenlängenmethode nicht benötigt werden. Bei der Benutzung von Stoffgesetzen in einer Finite-Element-Rechnung hängen die Ergebnisse stark von der Netzeinteilung ab. Um dies abzustellen, wird das Modell von Adachi und Oka auf der Grundlage von Bazant's Konzept der Nichtlokalisierung verallgemeinert. Anwendungsbeispiel ist das Verhalten von weichem Gestein im drainierten Triaxial-Test. Es zeigt sich, daß mit dem Konzept der Nichtlokalisierung im Stoffmodell der Einfluß der Netzeinteilung geringer wird.

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Presented at the workshop on Numerical Methods for Localization and Bifurcation of Granular bodies, held at the Technical University of Gdask (Poland), September 25–30, 1989.     

Control of vibronic excitation using quantum-correlated photons

We theoretically investigate the two-step excitation of a molecular vibronic state using quantum-correlated photons with time delay in order to control the population of the vibronic excited state. A Morse oscillator having three sets of vibronic states, namely, the ground state, intermediate states, and excited states, is used to evaluate the efficiency of the two-step excitation process. We show that we can efficiently and selectively excite only a target state by using correlated photons and can control the excitation population of the target state by adjusting the delay time of the correlated photons. The potential of controlling a chemical reaction using correlated photons is also discussed.     

Selective two-photon excitation of a vibronic state by correlated photons

We theoretically investigate the two-photon excitation of a molecular vibronic state by correlated photons with energy anticorrelation. A Morse oscillator having three sets of vibronic states is used, as an example, to evaluate the selectivity and efficiency of two-photon excitation. We show that a vibrational mode can be selectively excited with high efficiency by the correlated photons, without phase manipulation or pulse-shaping techniques. This can be achieved by controlling the quantum correlation so that the photon pair concurrently has two pulse widths, namely, a temporally narrow width and a spectrally narrow width. Though this concurrence is seemingly contradictory, we can create such a photon pair by tailoring the quantum correlation between two photons.     

Preparative purification of gentamicin components using high-speed counter-current chromatography coupled with electrospray mass spectrometry

We developed a useful and preparative method based on high-speed counter-current chromatography with mass spectrometry (HSCCC/MS) to purify gentamicin C1a, C2/2a and C1 from standard powder. The analytes were purified on the HSCCC model CCC-1000 (multi-layer coil planet centrifuge) with a volatile two-phase solvent system composed of n-butanol/10% aqueous ammonia solution (50:50, v/v) and detected on an LCMS-2020EV quadrupole mass spectrometer fitted with an electrospray ionization (ESI) source system in positive ionization following scan mode (m/z 100-500). The HSCCC/ESI-MS peaks indicated that gentamicin C1a (m/z 450: [M+H](+)), C2/2a (m/z 464: [M+H](+)) and C1 (m/z 478: [M+H](+)) have the peak resolution values of 1.3 and 1.7 from 30 mg of loaded gentamicin powder. The HSCCC yielded 3.9 mg of gentamicin C1a, 12.6 mg of gentamicin C2/2a and 12.0 mg of gentamicin C1. These purified substances were analyzed by LC/MS with scan positive-mode. Based on the LC/MS chromatograms and spectra of the fractions, analytes were estimated to be over 95% pure. These gentamicin isomers of C1a, C2/2a and C1 were evaluated for their antibacterial activities. The overall results indicate that this approach of HSCCC/MS is a powerful technique for the purification of gentamicin components.     

Ultrafast excited state dynamics of fucoxanthin: excitation energy dependent intramolecular charge transfer dynamics

Carotenoids containing a carbonyl group in conjugation with their polyene backbone are naturally-occurring pigments in marine organisms and are essential to the photosynthetic light-harvesting function in aquatic algae. These carotenoids exhibit spectral characteristics attributed to an intramolecular charge transfer (ICT) state that arise in polar solvents due to the presence of the carbonyl group. Here, we report the spectroscopic properties of the carbonyl carotenoid fucoxanthin in polar (methanol) and nonpolar (cyclohexane) solvents studied by steady-state absorption and femtosecond pump-probe measurements. Transient absorption associated with the optically forbidden S(1) (2(1)A) state and/or the ICT state were observed following one-photon excitation to the optically allowed S(2) (1(1)B) state in methanol. The transient absorption measurements carried out in methanol showed that the ratio of the ICT-to-S(1) state formation increased with decreasing excitation energy. We also showed that the ICT character was clearly visible in the steady-state absorption in methanol based on a Franck-Condon analysis. The results suggest that two spectroscopic forms of fucoxanthin, blue and red, exist in the polar environment.     

Polarimetry for spatiotemporal photoelastic analysis

This paper describes a new photoelastic technique for the spatiotemporal stress analysis. In a polarimeter developed, an elliptically polarized signal beam of light, modulated in state of polarization by two-dimensional principal-stress distributions interferes with a reference beam of light consisting of orthogonal linearly polarized two components. A time-sequential series of two-dimensional interference patterns are received one after another by a MOS video camera, followed by a computer. Of the elliptically polarized signal beam, the orthogonal field components along the directions of the principal stresses in a two-dimensional photoelastic sample can be computed from a recorded interference pattern, which offer the data needer for mapping the spatiotemporal principal-stress distribution over the sample. Not only each of the two orthogonal principal stresses but also the principal-stress difference are mapped in a time-sequential diagram. No use of any movable polarization element such as a rotating analyzer allows us to follow a rapid change in stress distribution within the maximum frame rate 2066 s⁻¹ of the MOS video camera.     

An ergodic theorem for asymptotically nonexpansive mappings in the intermediate sense

This paper is concerned with an ergodic theorem for asymptotically nonexpansive mappings in the intermediate sense in Banach spaces.