A novel temperature responsive water-soluble glycopolymer was synthesised via copper wire-catalysed click-polymerisation. Di-hydroxyl terminated poly(ethylene glycol) was quantitatively alkyne end-capped to yield di-alkyne terminated poly(ethylene glycol) (DAT-PEG). 2,3,4,2′,3′,4′-hexa-O-acetyl-6,6′-diazido-6,6′-dideoxy-α,α-D-trehalose (HADADT) was prepared from the di hydrated α,α-D-Trehalose by tosylation/acetylation followed by azidation. Click-polymerisation reaction between DAT-PEG and HADADT was successfully carried out to produce an alternating glycopolymer with triazole rings as linkers in high yield. All the intermediates as well as the glycopolymer were fully characterised by NMR, MS, IR, SEC, TGA and DSC. The cloud point of the aqueous solution of glycopolymer was investigated by optical microscopy and UV–vis spectroscopy. The LCST was found to be within physiological range of about 39 °C, known as fever temperature. 相似文献
Triphenyl phosphite reacts smoothly with dialkyl acetylenedicarboxylates and hexachloroacetone to produce alkyl 2‐(dichloromethylene)‐2,5‐dihydro‐5‐oxo‐4‐(trichloromethyl)furan‐3‐carboxylates in good yields. 相似文献
An efficient experimentally simple and inexpensive catalyst system for the selective amidation of aryl iodides using 15 mol% of CuI as catalyst, 15 mol% of L-proline as ligand and KF/Al2O3 as a base in toluene is described. 相似文献
Research on anticancer properties of natural compounds, as effective materials that are available while causing minimal side effects, is growing. Ellagic acid (EA) is a well-known polyphenolic compound, which has been found in both free and complex modes in several medicinal plants such as pomegranate, walnut, and berries. Although many articles have reported anticancer properties for this compound, its mechanism of action has not been fully elucidated. In this study, we used several online and offline bioinformatics tools and databases to identify the mechanism of action of EA on various types of human malignancies including bladder, blood, breast, cervical, colorectal, liver, pancreas, and prostate cancers. In this context, after identifying and extracting EA-affected human genes/proteins that have been reported in various references, we built the related gene networks and determined functional hub genes. In addition, docking was performed to recognize target proteins that react directly with EA and are in fact most affected by this compound. Our findings revealed that EA exerts its anticancer effects by influencing specific hub genes in various types of cancers. Moreover, different cellular signaling pathways are affected by this natural compound. Generally, it turned out that EA probably exerts most of its anticancer activities, through induction of apoptosis, as well as P53 and WNT signaling pathways, and also by affecting the expression of several hub genes such as CDKN1A, CDK4, CDK2, CDK6, TP53, JUN, CCNA2, MAPK14, CDK1, and CCNB1 and especially interactions with some related proteins including P53, CDK6, and MAPK14.
Molecular Diversity - Soluble epoxide hydrolase (sEH) enzyme plays an important role in the metabolism of endogenous chemical mediators, epoxyeicosatrienoic acids, which are involved in the... 相似文献