Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing32P as well as for the estimation of99 Mo and199Au

As part of an examination of the cytostatic effects of 1,2-diarylethylenediamine-platinum(II)-complexes the contents of platinum and biologically essential trace elements of tumour tissue and different organs were determined. The activation analysis procedure — separation of³²P, isolation of¹⁹⁹Au and⁹⁹Mo — is described. In the course of a pharmakokinetical experiment with tumourbearing rats (DMBA induced hormone-dependent tumours) the desired enrichment of the administered drug in the tumour tissue was found. Changes of the trace element level of tumour tissue were found for hormone-dependent MXT-mammary tumours on mice.     

Interaction antieigenvalues

The notion of interaction antieigenvalue, which I mentioned over thirty years ago but which to date has not been elaborated, will be briefly elaborated here. New bounds will be obtained from it.     

A Variable Neighborhood Search for the Multi Depot Vehicle Routing Problem with Time Windows

The aim of this paper is to propose an algorithm based on the philosophy of the Variable Neighborhood Search (VNS) to solve Multi Depot Vehicle Routing Problems with Time Windows. The paper has two main contributions. First, from a technical point of view, it presents the first application of a VNS for this problem and several design issues of VNS algorithms are discussed. Second, from a problem oriented point of view the computational results show that the approach is competitive with an existing Tabu Search algorithm with respect to both solution quality and computation times.     

A geometric theory forL 2-stability of the inverse problem in a one-dimensional elliptic equation from anH 1-observation

This study provides a stability theory for the nonlinear least-squares formulation of estimating the diffusion coefficient in a two-point boundary-value problem from an error-corrupted observation of the state variable. It is based on analysing the projection of the observation on the nonconvex attainable set.This research was started while G. Chavent visited the Technical University of Graz. Support through the Steiermaerkische Landesregierung is gratefully acknowledged.     

Interface analysis of the system Si/YBa2Cu3O7?x

Summary The influence of different preparation conditions and substrate surface orientations on the superconducting properties of thin YBa₂Cu₃O_7–x (YBCO) films on silicon was studied. Comparative electrical and surface spectroscopic measurements were performed. SAM and SIMS depth profile analysis show an enrichment of barium at the interface between the superconductor and silicon for samples with T_c<76 K. Comparison with XPS data obtained for thin silicon films on YBCO indicates the formation of barium and yttrium silicates at the interface under these conditions.     

Stationary remaining service time conditional on queue length

In Mandelbaum and Yechiali [The conditional residual service time in the M/G/1 queue, http://www.math.tau.ac.il/∼uriy/publications (No. 30a), 1979] and in Fakinos [The expected remaining service time in a single-server queue, Oper. Res. 30 (1982) 1014-1018] a simple formula is derived for the (stationary) expected remaining service time in a M/G/1 queue, conditional on the number of customers in the system. We give a short new proof of the formula using Rate Conservation Law, and generalize to handle higher moments.     

Jordan homomorphisms,chain geometries and the fundamental theorem

This research was supported by M.P.I. (R.S. 40%).