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51.
Ben Ohayon Joel Chocron Tsviki Hirsh Ayala Glick-Magid Yonatan Mishnayot Ish Mukul Hitesh Rahangdale Sergei Vaintraub Oded Heber Doron Gazit Guy Ron 《Hyperfine Interactions》2018,239(1):57
We review the current status of the radioisotopes program at the Soreq Applied Research Accelerator Facility (SARAF), where we utilize an electrostatic-ion-beam trap and a magneto-optical trap for studying the nuclear β-decay from trapped radioactive atoms and ions. The differential energy spectra of β’s and recoil ions emerging from the decay is sensitive to beyond standard model interactions and is complementary to high energy searches. The completed facility SARAF-II will be one of the world’s most powerful deuteron, proton and fast neutron sources, producing light radioactive isotopes in unprecedented amounts, needed for obtaining enough statistics for a high precision measurement. 相似文献
52.
In view of its possible role in a core-collapse supernova and in the subsequent nucleosynthesis, inelastic neutrino scattering with A = 3,4 nuclei is calculated. The predicted cross-sections result from an ab-initio calculation using microscopic two- and three-nucleon interaction and meson-exchange currents. 相似文献
53.
The high-speed stress-strain method of polymer impact strength evaluation possesses the advantages of standard low-speed stress-strain measurements: ultimate stress, ultimate strain and the shape of the curve are obtained, test speed can be arbitrarily controlled, and the stress is homogeneous and uniaxial. Using updated electronics, we have applied the method to a series of epoxy resins of different molecular weight between crosslinks. The results are reproducible and precise. While they agree in form with Izod results in this instance, the mode of deformation is different and disparity is found for other systems, e.g. two-phase rubber-epoxy composites. 相似文献
54.
Intrinsic Fluorescence of Metabolite Amyloids Allows Label‐Free Monitoring of Their Formation and Dynamics in Live Cells 下载免费PDF全文
Shira Shaham‐Niv Zohar A. Arnon Dorin Sade Dr. Alexandra Lichtenstein Dr. Evgeny A. Shirshin Dr. Sofiya Kolusheva Prof. Ehud Gazit 《Angewandte Chemie (International ed. in English)》2018,57(38):12444-12447
The formation of apoptosis‐inducing amyloidal structures by metabolites has significantly extended the “amyloid hypothesis” to include non‐proteinaceous, single metabolite building blocks. However, detection of metabolite assemblies is restricted compared to their larger protein‐based counterparts owing to the hindrance of external labelling and limited immunohistochemical detection tools. Herein, we present the detection of the formation, dynamics, and cellular distribution of metabolite amyloid‐like structures and provide mechanistic insights into the generation of supramolecular chromophores. Moreover, the intrinsic fluorescence properties allow the detection of metabolite assemblies in living cells without the use of external dyes. Altogether, this intrinsic fluorescence of metabolite assemblies further verifies their amyloidal nature, while providing an important tool for further investigation of their pathological role in inborn error of metabolism disorders. 相似文献
55.
Lieb-Robinson Bounds for Harmonic and Anharmonic Lattice Systems 总被引:1,自引:1,他引:0
Bruno Nachtergaele Hillel Raz Benjamin Schlein Robert Sims 《Communications in Mathematical Physics》2009,286(3):1073-1098
We prove Lieb-Robinson bounds for systems defined on infinite dimensional Hilbert spaces and described by unbounded Hamiltonians. In particular, we consider harmonic and certain anharmonic lattice systems. 相似文献
56.
Amdursky N Molotskii M Gazit E Rosenman G 《Journal of the American Chemical Society》2010,132(44):15632-15636
In the world of biology, "self-assembly" is the ability of biological entities to interact with one another to form supramolecular structures. One basic group of self-assembled structures is peptide nanotubes (PNTs). However, the self-assembly mechanism, with its special characteristics, is not yet fully understood. An exceptional quantum-confined approach is shown here for the self-assembly mechanism in bio-inspired materials. We found the elementary building block of the studied PNT, which is self-assembled from short peptides composed of two phenylalanine residues, to be 0D-quantum-confined (can be related to confinement in 3D), also called a quantum dot (QD). This elementary building block can further self-assemble to a PNT formation. It has been observed that the assembly process of dots to tubes and the disassembly process of tubes to dots are reversible. We further show that a similar dipeptide can also self-assemble to a QD-like structure, with different dimensions. The presented peptide QD structures are nanometer-sized structures, with pronounced exciton effects, which may promote the use of an entirely new kind of organic QDs. 相似文献
57.
Selective Inhibition of Aggregation and Toxicity of a Tau‐Derived Peptide using Its Glycosylated Analogues 下载免费PDF全文
Moran Frenkel‐Pinter Dr. Michal Richman Anna Belostozky Amjaad Abu‐Mokh Prof. Ehud Gazit Prof. Shai Rahimipour Prof. Daniel Segal 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(17):5945-5952
Protein glycosylation is a ubiquitous post‐translational modification that regulates the folding and function of many proteins. Misfolding of protein monomers and their toxic aggregation are the hallmark of many prevalent diseases. Thus, understanding the role of glycans in protein aggregation is highly important and could contribute both to unraveling the pathology of protein misfolding diseases as well as providing a means for modifying their course for therapeutic purposes. Using β‐O‐linked glycosylated variants of the highly studied Tau‐derived hexapeptide motif VQIVYK, which served as a simplified amyloid model, we demonstrate that amyloid formation and toxicity can be strongly attenuated by a glycan unit, depending on the nature of the glycan itself. Importantly, we show for the first time that not only do glycans hinder self‐aggregation, but the glycosylated peptides are capable of inhibiting aggregation of the non‐modified corresponding amyloid scaffold. 相似文献
58.
Stempler S Levy-Sakin M Frydman-Marom A Amir Y Scherzer-Attali R Buzhansky L Gazit E Senderowitz H 《Journal of computer-aided molecular design》2011,25(2):135-144
Inhibiting the aggregation process of the β-amyloid peptide is a promising strategy in treating Alzheimer’s disease. In this
work, we have collected a dataset of 80 small molecules with known inhibition levels and utilized them to develop two comprehensive
quantitative structure–activity relationship models: a Bayesian model and a decision tree model. These models have exhibited
high predictive accuracy: 87% of the training and test sets using the Bayesian model and 89 and 93% of the training and test
sets, respectively, by the decision tree model. Subsequently these models were used to predict the activities of several new
potential β-amyloid aggregation inhibitors and these predictions were indeed validated by in vitro experiments. Key chemical
features correlated with the inhibition ability were identified. These include the electro-topological state of carbonyl groups,
AlogP and the number of hydrogen bond donor groups. The results demonstrate the feasibility of the developed models as tools
for rapid screening, which could help in the design of novel potential drug candidates for Alzheimer’s disease. 相似文献
59.
60.
This study tested the accuracy of indirect methods of measurementof laryngeal airway resistance in normal subjects and in spasmodic dysphonia (SD). The indirect method assumes that subglottic air pressure remains constant during the voiced segment of a syllable. In this study subglottic air pressure was directly measured via puncture of the cricothyroid membrane in seven normal subjects and seven subjects with SD. The true laryngeal airway resistance was calculated and compared with airway resistance measured using indirect techniques based on intraoral air pressure. In five of the seven normal subjects, subglottic air pressure did not remain constant during the voiced segment. As a result, the error produced using indirect method of calculating average laryngeal resistance for the normal subjects varied from −44% to +50%. For SD subjects the error ranged from −49% to +22%. In general, the indirect technique over-estimated laryngeal airway resistance in normal subjects and underestimated the resistance in subjects with SD. 相似文献