全文获取类型
收费全文 | 682篇 |
免费 | 34篇 |
国内免费 | 5篇 |
专业分类
化学 | 564篇 |
晶体学 | 6篇 |
力学 | 23篇 |
数学 | 58篇 |
物理学 | 70篇 |
出版年
2022年 | 10篇 |
2021年 | 45篇 |
2020年 | 33篇 |
2019年 | 30篇 |
2018年 | 15篇 |
2017年 | 26篇 |
2016年 | 34篇 |
2015年 | 21篇 |
2014年 | 31篇 |
2013年 | 63篇 |
2012年 | 42篇 |
2011年 | 51篇 |
2010年 | 28篇 |
2009年 | 26篇 |
2008年 | 39篇 |
2007年 | 47篇 |
2006年 | 26篇 |
2005年 | 31篇 |
2004年 | 18篇 |
2003年 | 17篇 |
2002年 | 8篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1998年 | 3篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 6篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 5篇 |
1985年 | 5篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1941年 | 1篇 |
排序方式: 共有721条查询结果,搜索用时 234 毫秒
91.
Mamdouh Nabil Samy Ashraf Nageeb El-Sayed Hamed Sachiko Sugimoto Hideaki Otsuka Mohamed Salah Kamel 《Natural product research》2016,30(8):967-972
A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC50: 52.6 ± 1.70 and 41.3 ± 0.25 μM, respectively) comparable with that of the standard trolox (16.6 ± 2.2 μM) without any significant cytotoxicity towards human cell line A549 (IC50 > 100 μM). 相似文献
92.
Sugar-assisted ligation (SAL) presents an attractive strategy for the synthesis of glycopeptides, including the synthesis of cysteine-free beta-O-linked and N-linked glycopeptides. Here we extended the utility of SAL for the synthesis of alpha-O-linked glycopeptides and glycoproteins. In order to explore SAL in the context of glycoprotein synthesis, we developed a new chemical synthetic route for the alpha-O-linked glycoprotein diptericin epsilon. In the first stage of our synthesis, diptericin segment Cys(Acm)37-Gly(52) and segment Val(53)-Phe(82) were assembled by SAL through a Gly-Val ligation junction. Subsequently, after Acm deprotection, diptericin segment Cys(37)-Phe(82) was ligated to segment Asp(1)-Asn(36) by means of native chemical ligation (NCL) to give the full sequence of diptericin epsilon. In the final synthetic step, hydrogenolysis was applied to remove the thiol handle from the sugar moiety with the concomitant conversion of mutated Cys(37) into the native alanine residue. In addition, we extended the applicability of SAL to the synthesis of glycopeptides containing cysteine residues by carrying out selective desulfurization of the sulfhydryl-modified sugar moiety in the presence of acetamidomethyl (Acm) protected cysteine residues. The results presented here demonstrated for the first time that SAL could be a general and useful tool in the chemical synthesis of glycoproteins. 相似文献
93.
Payne RJ Ficht S Tang S Brik A Yang YY Case DA Wong CH 《Journal of the American Chemical Society》2007,129(44):13527-13536
Recently, we reported the development of sugar-assisted ligation (SAL), a novel peptide ligation method for the synthesis of glycopeptides. After screening a large number of glycoprotein sequences in a glycoprotein database, it became evident that a large proportion (approximately 53%) of O-glycosylation sites contain amino acid residues that will not undergo SAL reactions. To overcome these inherent limitations and broaden the scope of the method we report here the development of an extended SAL method. Glycopeptides containing up to six amino acid extensions N-terminal to the glycosylated residue were shown to facilitate ligation reactions with peptide thioesters, and these products were isolated in good yields. Kinetic analysis was used to show that as glycopeptides were extended by further amino acid residues, ligation reactions became slower. This finding was rationalized by molecular dynamics simulations using AMBER9. These studies suggested a general trend whereby the proximal distance between the reactive sites of the thioester intermediate (the N-terminal amine and the carbonyl carbon of the thioester) increased as glycopeptides were extended, thus slowing down the ligation rate. Each of the extended SAL methods showed broad tolerance to a number of different amino acid combinations at the ligation junction. Re-evaluation of the glycoprotein database suggested that 95% of the O-linked glycosylation sites can now be utilized to facilitate SAL or extended SAL reactions. As such, this method represents an extremely valuable tool for the synthesis of naturally occurring glycopeptides and glycoproteins. To demonstrate the applicability of the method, extended SAL was successfully implemented in the synthesis of the starting unit of the cancer-associated MUC1 glycoprotein. 相似文献
94.
Iqbal A Siddiqui HL Ashraf CM Bukhari MH Akram CM 《Chemical & pharmaceutical bulletin》2007,55(7):1070-1072
Thirteen new Schiff bases derived from p-nitrobenzaldehyde were synthesized by condensation with the appropriate amines. An unusual reduction of the p-nitrobenzaldehyde to the corresponding alcohol was also observed in one of the reactions. The structures of the compounds were identified using spectroscopic techniques. Cytotoxicity for the titled compounds was studied against Brine Shrimp, used as the test animal. 相似文献
95.
Syed Amir Ashraf Abd Elmoneim O. Elkhalifa Khalid Mehmood Mohd Adnan Mushtaq Ahmad Khan Nagat Elzein Eltoum Anuja Krishnan Mirza Sarwar Baig 《Molecules (Basel, Switzerland)》2021,26(19)
Diabetes mellitus is a global threat affecting millions of people of different age groups. In recent years, the development of naturally derived anti-diabetic agents has gained popularity. Okra is a common vegetable containing important bioactive components such as abscisic acid (ABA). ABA, a phytohormone, has been shown to elicit potent anti-diabetic effects in mouse models. Keeping its anti-diabetic potential in mind, in silico study was performed to explore its role in inhibiting proteins relevant to diabetes mellitus- 11β-hydroxysteroid dehydrogenase (11β-HSD1), aldose reductase, glucokinase, glutamine-fructose-6-phosphate amidotransferase (GFAT), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and Sirtuin family of NAD(+)-dependent protein deacetylases 6 (SIRT6). A comparative study of the ABA-protein docked complex with already known inhibitors of these proteins relevant to diabetes was compared to explore the inhibitory potential. Calculation of molecular binding energy (ΔG), inhibition constant (pKi), and prediction of pharmacokinetics and pharmacodynamics properties were performed. The molecular docking investigation of ABA with 11-HSD1, GFAT, PPAR-gamma, and SIRT6 revealed considerably low binding energy (ΔG from −8.1 to −7.3 Kcal/mol) and predicted inhibition constant (pKi from 6.01 to 5.21 µM). The ADMET study revealed that ABA is a promising drug candidate without any hazardous effect following all current drug-likeness guidelines such as Lipinski, Ghose, Veber, Egan, and Muegge. 相似文献
96.
Photoconductivity measurements are carried out in this work for single crystals of Tl4S3 compound by using both pulsed excitation (a.c) and steady state (a.c) methods in order to elucidate the nature of photoconductivity (PC) in this compound. Results are reported in the temperature range from 77 to 300 K, excitation intensity range from 1800 to 3300 Lux, applied voltage range from 8 to 14 V, and wavelength range from 840 to 1450 nm. Both of the ac‐photoconductivity (ac‐PC) and the spectral distribution of the photocurrent are studied at different values of light intensity, applied voltage and temperature. Dependencies of carrier lifetime on light intensity, applied voltage and temperature are also investigated as results of the ac‐PC measurements. By using the results of the dc‐photoconductivity (dc‐PC) measurements, the temperature dependence of the energy gap width is described. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
97.
The Tl2S compound was prepared in a single crystal form using a special local technique, and the obtained crystals were analysed
by X-ray diffraction. For the resultant crystals, the electrical properties (electrical conductivity and Hall effect) and
steady-state photoconductivity were elucidated in this work. The electrical measurements extend from 170 to 430 K, where it
was found that σ
⊥ = 8.82 × 10−5 Sm−1 when current flow direction makes right angle to the cleavage plane of the crystals. In the same range of temperatures, it
was found that σ
‖ = 4.73 × 10−5 Sm−1 when the current flow is parallel to the cleavage plane. In line with the investigated range of temperatures, the widths
of the band gaps were calculated and discussed as also the results of the electrical conductivity and Hall effect measurements.
In addition, the anisotropy of the electrical conductivity (σ
⊥/σ
‖) for the obtained crystals was also studied in this work. Finally the photosensitivity was calculated for different levels
of illumination as a result of the photoconductivity measurements, which showed that the recombination process in Tl2S single crystals is a monomolecular process.
相似文献
98.
Ashraf A. Mohamed 《Monatshefte für Chemie / Chemical Monthly》2009,375(5):9-14
Abstract
Two simple, sensitive, and selective spectrophotometric methods were developed for determining amodiaquine (AQ) and chloroquine (CQ) based on their oxidation with potassium iodate and potassium bromate, respectively. The initial rates of oxidation of AQ and CQ were monitored at 342 and 343 nm, the wavelengths of maximum absorptions of the two drugs. The various experimental parameters affecting oxidation reactions were thoroughly studied and optimized. Beer’s law was obeyed for 0.2–4.0 and 0.5–5.0 μg cm−3, with correlation coefficients of 0.9999 and 0.9998 (n = 6) and a detection limit (based on the 3S b -criterion) of 0.04 and 0.06 μg cm−3 for AQ and CQ. The proposed methods were conveniently applied to determining AQ and CQ in pure and dosage forms. 相似文献99.
100.
Ya‐Ching Shen Pei‐Show Shih Yun‐Sheng Lin Yu‐Chi Lin Yao‐Haur Kuo Yuh‐Chi Kuo Ashraf Taha Khalil 《Helvetica chimica acta》2009,92(10):2101-2110
Chemical investigation of the sponge Ircinia formosana resulted in the isolation of seven new linear C22‐sesterterpenoids, irciformonins E–K ( 1 – 7 ) in addition to irciformonin A ( 8 ), a previously isolated furanosesterterpenoid (=a furan‐moiety‐containing sesterterpenoid) from the same species. The structures were determined by interpretation of HR‐ESI‐MS and 2D‐NMR spectra. The structure of irciformonin A ( 8 ) was revised. Compound 5 exhibited significant inhibition of peripheral blood mononuclear cell proliferation induced by phytohemaglutinin. 相似文献