Efficient photocurrent generation by SnO2 electrode modified electrophoretically with composite clusters of porphyrin-modified silica microparticle and fullerene

A silica microparticle has been successfully employed as a nanoscaffold to self-organize porphyrin and C60 molecules on a nanostructured SnO2 electrode which exhibits efficient photocurrent generation.     

Electron tomography of Nafion ionomer coated on Pt/carbon black in high utilization electrode for PEFCs

To confirm the superiority of newly developed electrocatalyst layer (ECL) for polymer electrolyte fuel cells, three-dimensional dispersion states of Nafion ionomer in Pt/carbon black agglomerates were analyzed by electron tomography based on multiple TEM images taken at different tilt angles. Uniform distribution of the ionomer has been first observed, proving the high catalyst utilization in the new ECL distinctive from that of the conventional one.     

Concrete models and dynamic instruments as early technology tools in classrooms at the dawn of ICMI: from Felix Klein to present applications in mathematics classrooms in different parts of the world

Most national curricula for both primary and secondary grades encourage the active involvement of learners through the manipulation of materials (either concrete models or dynamic instruments). This trend is rooted in the emphasis given, at the dawn of ICMI, to what might be called an experimental approach: the links between mathematics, natural sciences and technology were in the foreground in the early documents of ICMI and also in the papers of its first president, Felix Klein. However, the presence of this perspective in teaching practice is uneven. In this paper, we shall reconstruct first an outline of what happened in three different parts of the world (Europe, USA and Japan) under the direct influence of Klein. Then, we shall report classroom activities realized in the same regions in three different research centres: the Laboratory of Mathematical Machines at the University of Modena and Reggio Emilia, Italy (http://www.mmlab.unimore.it); the pedagogical space of Kinematical Model for Design Digital Library at Cornell, USA (http://kmoddl.library.cornell.edu/); and the Centre for Research on International Cooperation in Educational Development at Tsukuba University, Japan (http://math-info.criced.tsukuba.ac.jp/). They have maintained the reference to concrete materials (either models or instruments), with original interpretations that take advantage of the different cultural conditions. Although in all cases the reference to history is deep and systematic, the synergy with mathematical modelling and with information and communication technologies has been exploited, not to substitute but to complement the advantages of the direct manipulations.     

Prospective trial of a navigator setting under left hepatic lobe on magnetic resonance cholangiopancreatography using a free-breathing prospective acquisition correction technique

PURPOSE: To prospectively compare the image acquisition time and image quality obtained by navigator setting under the left hepatic lobe vs. on the right diaphragm on magnetic resonance cholangiopancreatography (MRCP) using a free-breathing navigator-triggered prospective acquisition correction technique (PACE). MATERIALS AND METHODS: Fifty consecutive patients prospectively underwent three-dimensional T2-weighted turbo spin-echo MRCP using PACE with the navigator randomly set either under the left hepatic lobe or on top of the right diaphragm. Image acquisition time and subjective image quality were compared on a five-point scale using Student's t-test and Mann-Whitney's U test, respectively. RESULTS: There was no significant difference for mean acquisition time (6.1+/-1.6 vs. 6.3+/-1.2 min, P=.689) between the left hepatic lobe group and right diaphragm group. Mean subjective image quality was significantly worse in the left hepatic lobe group than in the right diaphragm group (4.1 vs. 4.7, P=.044). CONCLUSION: Setting the navigator under the left hepatic lobe for MRCP using PACE causes the data processing to be more difficult. As well, under current circumstances, it does not contribute to reducing acquisition time or improving the image quality.     

Tuning the Electronic Properties and Acid‐Response Behavior of N‐Heteroacene‐Based π‐Conjugated Liquids by Changing the Number of π‐Conjugated Substituents

We have designed and synthesized two room‐temperature‐fluorescent π‐conjugated liquids based on the N‐heteroacene framework ( 1 and 2 ). These two π‐conjugated liquids, which contained one and two thiophene rings, respectively, exhibited different electronic properties and rheology behaviors. Single‐crystal X‐ray analysis of dithiophene‐appended compound 4 revealed that two thiophene rings hindered the interactions of the imino N atoms with acids through the formation of interactions between the S atoms of the thiophene rings and the imino N atoms of the pyrazine group. On the other hand, monothiophene‐appended molecules 1 and 3 each contained an unhindered imino N atom on the opposite site to the thiophene ring. Upon dissolving various acids with different pK_a values in compounds 1 and 2 , these slight structural differences gave rise to marked differences in their acid‐response behaviors, thereby resulting in the emission of variously colored fluorescence in the liquid state. Furthermore, when acids with lower pK_a values was dissolved in compounds 1 and 2 , phase transition occurred from an isotropic liquid state to a self‐organized liquid‐crystalline phase.     

Development of pyrrole-imidazole polyamide for specific regulation of human aurora kinase-A and -B gene expression

Pyrrole-imidazole polyamide (PIP) is a nuclease-resistant novel compound that inhibits gene expression through binding to the minor groove of DNA. Human aurora kinase-A (AURKA) and -B (AURKB) are important regulators in mitosis during the cell cycle. In this study, two specific PIPs (PIP-A and PIP-B) targeting AURKA and AURKB promoter regions were designed and synthesized, and their biological effects were investigated by several in vitro assays. PIP-A and PIP-B significantly inhibited the promoter activities, mRNA expression, and protein levels of AURKA and AURKB, respectively, in a concentration-dependent manner. Moreover, 1:1 combination treatment with both PIPs demonstrated prominent antiproliferative synergy (CI value [ED(50)] = 0.256) to HeLa cells as a result of inducing apoptosis-mediated severe catastrophe of cell-cycle progression. The novel synthesized PIP-A and PIP-B are potent and specific gene-silencing agents for AURKA and AURKB.     

Stability due to peripheral halogenation in phthalocyanine complexes.

The effect of peripheral halogenation is examined based on analytical transmission electron microscopy and thermal analyses of two chemical family structures, specifically the vanadyl-phthalocyanine family (VOPcX: X = H16, F14.5) and the copper-phthalocyanine family (CuPcX: X = H16, F16, Cl16, Cl8Br8), focusing on the process of molecular changes and crystalline disintegrations. To clarify the molecular transformations, electron energy-loss spectroscopy (EELS) is applied to two fluorinated phthalocyanines (VOPcF14.5 and CuPcF16), by monitoring mass changes as well as energy loss near edge structures (ELNES). The elemental mass of both VOPcF14.5 and CuPcF16 remain constant up to 0.5 C x cm(-2), except in the case of mass reduction attributed to oxygen loss occurring in VOPcF14.5. It is expected that the released oxygen will induce higher radiation damage in VOPcF14.5. Although mass variation is not observed in CuPcF16, it is found from ELNES that the pi resonant system of nitrogen is more radiation sensitive than that of carbon. These results imply that the electron sensitivity in VOPcX is triggered by eliminated oxygen or, thus, an induced larger empty space, whereas the sensitivity of CuPcX is dominated only by a large intermolecular empty space resulting in the following bond alterations. It is also found that the decomposition temperature (Td) measured by thermal analyses and the characteristic dose (D1/e) are exponentially correlated to the "effective molecular occupancy" (Oe) evaluated as a volume function of molecules in unit cells. By measuring Td and/or Oe, we discuss the durability of peripheral halogenation with respect to the radiation damage.     

Effects of magnesium salts and amines on the stereoselectivity in the imine aldol reaction

In the imine aldol reactions of 1 with aromatic aldehydes using magnesium salts in the presence of amines, the threo/erythro ratios of products increased in the order Mg(ClO4)2>MgI2>MgBr2>MgCl2>Mg(OTf)2 and N,N,N',N'-tetramethylethylenediamine (TMEDA)>Et3N. This increase in the threo/erythro ratios of products was estimated to be caused by a retro-imine aldol reaction under thermodynamic control.     

Formation of intermediate micellar phase between hexagonal and discontinuous cubic liquid crystals in brine/N-acylamino acid surfactant/N-acylamino acid oil system

The phase behavior in the brine/sodium N-dodecanoyl sarcosinate (Sar)/isopropyl N-dodecanoyl sarcosinate (SLIP) system has been investigated by means of phase study, static light scattering, and small-angle X-ray scattering. The liquid crystal phases, hexagonal (H(1)) and discontinuous cubic (I(1)), melt upon the addition of NaCl, which shows the similar effect to the increasing of temperature. The addition of SLIP to the brine/Sar solution at high Sar concentration induces the phase transition from H(1) to I(1) via the isotropic micellar solution (W(m2)). The micellar structure in the W(m2) phase also changes from the wormlike to the globular micelle with SLIP concentration. Adding NaCl reduces the repulsive force between the Sar head groups and simultaneously the space of the solubilized SLIP in the palisade layer, leading SLIP to shift their location further into the micelle core. As a consequence, the hexagonal symmetry breaks into the micelle solution and the liquid crystal order is destabilized entropically.