Stereochemistry of the hygrolidins

The stereochemistry shown in 6 has been determined by computer modelling for hygrolidin, prototypical member of a new class of macrolide antibiotics.     

The 1,3 O→C silyl rearrangement of silyl enol ether anions - synthesis of α-silyl ketones

Silyl enol ethers with sterically hindered silyl groups are transformed into the corresponding α-silyl ketones by treatment with n-butyllithium/potassium tert-butylate.     

Regiospecific synthesis of (±)-deoxyanthracyclinones

A versatile regiospecific route to tetracyclic anthracyclinones is described; the synthetic strategy entails the attachment of a nucleophilic C-D ring synthon, $\text{2b}$, to a suitably functionalized A ring intermediate such as $\text{3}$.     

Synthesis of two position isomers of leukotriene C having the S-peptide at C(12)

Two positional isomers of leukotriene C(1) (4a,4b), previously considered as possibly being members of the family of slow reacting substances, have been synthesized and found to be biologically inactive.