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981.
The compression behavior of some rubberlike networks in equilibrium and non-equilibrium conditions has been investigated. The experimental data clearly indicate that non-equilibrium components are operative on the compression modulus value. Results are interpreted in terms of supramolecular order in the amorphous materials. 相似文献
982.
Carlotta Borgarelli Yvonne E. Klingl Dr. Abril Escamilla-Ayala Prof. Dr. Sebastian Munck Prof. Dr. Ludo Van Den Bosch Prof. Dr. Wim M. De Borggraeve Dr. Ermal Ismalaj 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(34):8605-8641
Despite the fact that transmembrane proteins represent the main therapeutic targets for decades, complete and in-depth knowledge about their biochemical and pharmacological profiling is not fully available. In this regard, target-tailored small-molecule fluorescent ligands are a viable approach to fill in the missing pieces of the puzzle. Such tools, coupled with the ability of high-precision optical techniques to image with an unprecedented resolution at a single-molecule level, helped unraveling many of the conundrums related to plasma proteins’ life-cycle and druggability. Herein, we review the recent progress made during the last two decades in fluorescent ligand design and potential applications in fluorescence microscopy of voltage-gated ion channels, ligand-gated ion channels and G-coupled protein receptors. 相似文献
983.
A. GabrielliI. D?Antone F.M. GiorgiI. Lax M. LolliR. De Leo G. De RobertisM. Foresta F. LoddoA. Ranieri G. CosentinoP. Finocchiaro A.D. PappalardoR. Fonte C. CalviniP. Musico P. OttonelloF. Cusanno F. GaribaldiT. Gigli F. GioveB. Maraviglia F. MeddiA. Rivetti 《Nuclear Physics B - Proceedings Supplements》2011,215(1):165-167
984.
A. BallaG. Bencivenni M. CapodiferroS. Cerioni P. CiambroneE. De Lucia G. De RobertisA. Di Domenico D. Domenici J. DongG. Felici M. GattaM. Jacewicz N. LacalamitaS. Lauciani R. LiuzziF. Loddo M. MongelliM. Morello V. PateraA. Pelosi M. PistilliL. Quintieri A. RanieriM. Schioppa E. TshadadzeV. Valentino 《Nuclear Physics B - Proceedings Supplements》2011,215(1):76-78
985.
986.
987.
V.Yu. Aristov O.V. Molodtsova D.V. Vyalikh M. Knupfer P. De Padova G. Le Lay 《Journal of Electron Spectroscopy and Related Phenomena》2010
High-resolution core-level data from the prototypical In/Si(1 1 1) system have been acquired at 10 K. An asymmetric tail in the In 4d spectra reveals a metallic character of the low temperature Si(1 1 1)8 × 2 phase confined to the inner indium rows. The decoupling of the one-dimensional inner indium chains from any metallic environment at ∼10 K suggests a possible Luttinger liquid behavior. At room temperature essentially a broadening of the spectral features is noticed, which appears compatible with a fluctuation scenario. 相似文献
988.
989.
Maurice J. Ahsman Bart C. van der Nagel Ron A. Mathot 《Biomedical chromatography : BMC》2010,24(9):969-976
Currently, pharmacokinetic–pharmacodynamic studies of sedatives and analgesics are performed in neonates and children to find suitable dose regimens. As a result, sensitive assays using only small volumes of blood are necessary to determine drug and metabolite concentrations. We developed an ultra‐performance liquid chromatographic method with tandem mass spectrometry detection for quantification of midazolam, 1‐hydroxymidazolam, hydroxymidazolamglucuronide, morphine, morphine‐3‐glucuronide and morphine‐6‐glucuronide in 100 μL of plasma. Cleanup consisted of 96 wells micro‐solid phase extraction, before reversed‐phase chromatographic separation (ultra‐performance liquid chromatography) and selective detection using electrospray ionization tandem mass spectrometry. Separate solid‐phase extraction methods were necessary to quantify morphine, midazolam and their metabolites because of each group's physicochemical properties. Standard curves were linear over a large dynamic range with adequate limits of quantitation. Intra‐ and interrun accuracy and precision were within 85–115% (of nominal concentration using a fresh calibration curve) and 15% (coefficient of variation, CV) respectively. Recoveries were >80% for all analytes, with interbatch CVs (as a measure of matrix effects) of less than 15% over six batches of plasma. Stability in plasma and extracts was sufficient, allowing large autosampler loads. Runtime was 3.00 min per sample for each method. The combination of 96‐well micro‐SPE and UPLC‐MS/MS allows reliable quantification of morphine, midazolam and their major metabolites in 100 μL of plasma. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
990.
Carmen FestaSimona De Marino Valentina SepeMaria Valeria D’Auria Giuseppe BifulcoRosa Andrés Maria Carmen TerencioMiguel Payá Cécile DebitusAngela Zampella 《Tetrahedron》2011,67(40):7780-7786
Two new cyclopeptides, perthamides E and F were isolated from the polar extracts of the sponge Theonella swinhoei. The new structures, featuring an unprecedented β-amino acid unit (AHMOA), were determined by interpretation of NMR and MS data. The absolute configuration of the AHMOA residue was proposed on the basis of quantum chemical calculation of NMR chemical shifts. Perthamides were proved to inhibit TNF-α and IL-8 release in primary human keratinocytes cells and therefore could represent potentially leads for the treatment of psoriasis. 相似文献