Phytochemical Analysis,Antispasmodic, Myorelaxant,and Antioxidant Effect of Dysphania ambrosioides (L.) Mosyakin and Clemants Flower Hydroethanolic Extracts and Its Chloroform and Ethyl Acetate Fractions

Dysphania ambrosioides (L.) Mosyakin and Clemants is an annual or ephemeral perennial herb used traditionally in the Mediterranean region in folk medicine to treat various illnesses, including those related to the digestive system. This study aims to assess the antispasmodic, myorelaxant, and antioxidant effects of D. ambrosioides flower hydroethanolic extract and its chloroform and ethyl acetate fractions in a comparative study to evaluate the result of the extraction type on the potential activity of the extract. Both rat and rabbit jejunum were used to evaluate the antispasmodic and myorelaxant effect, while the antioxidant effect was evaluated using DPPH, a ferric reducing power assay, and a beta-carotene bleaching test. LC/MS-MS analysis was carried out to reveal the composition of the different types of extract. Following the results, the hydroethanolic extract showed a significant myorelaxant effect (IC₅₀ = 0.39 ± 0.01 mg/mL). Moreover, it was shown that the hydroethanolic extract demonstrated the best antispasmodic activity (IC₅₀ = 0.51 ± 0.05 mg/mL), followed by the ethyl acetate (IC₅₀ = 4.05 ± 0.32 mg/mL) and chloroform (IC₅₀ = 4.34 ± 0.45 mg/mL) fractions. The antioxidant tests showed that the hydroethanolic extract demonstrated high antioxidant activity, followed by the ethyl acetate and chloroform fractions. The LC/MS-MS analysis indicates that the plant extract was rich in flavonoids, to which the extract activity has been attributed. This study supports the traditional use of this plant to treat digestive problems, especially those with spasms.     

The optimum conditions for methanol conversion to dimethyl ether over modified sulfated zirconia catalysts prepared by different methods

Sulfated zirconia (SZ) and two promoted 1%Mn/SZ catalysts which have been prepared via sol gel (Mn/SZ-S) and impregnation (Mn/SZ-I) methods were studied.The morphology of the catalysts was characterized by XRD,BET,NH_3-TPD,ICP,SEM and FT-IR analysis.The conversion of methanol to dimethyl ether and hydrocarbons was carried out in the temperature range of 120-300 ℃.The Mn/SZ-S showed the highest activity due to the high surface area with suitable acidity.The optimum condition of Mn/SZ-S catalyst was investigated at 200°C and LHSV of 0.02 h~(-1) in a time range from 30 to 210 min.It was found that the total conversion decreased from 80.18% to 53.26% at 210 min.The reusability of this catalyst was studied at the optimum condition up till four cycles for 1 h.The characterization of the reused catalyst showed a significant change in the structure and surface acidity due to the blockage of the surface acid sited by carbonaceous materials.     

A Generalized Spatial Modulation System Using Massive MIMO Space Time Coding Antenna Grouping

Massive multiple input multiple output (MIMO), also known as a very large-scale MIMO, is an emerging technology in wireless communications that increases capacity compared to MIMO systems. The massive MIMO communication technique is currently forming a major part of ongoing research. The main issue for massive MIMO improvements depends on the number of transmitting antennas to increase the data rate and minimize bit error rate (BER). To enhance the data rate and BER, new coding and modulation techniques are required. In this paper, a generalized spatial modulation (GSM) with antenna grouping space time coding technique (STC) is proposed. The proposed GSM-STC technique is based on space time coding of two successive GSM-modulated data symbols on two subgroups of antennas to improve data rate and to minimize BER. Moreover, the proposed GSM-STC system can offer spatial diversity gains and can also increase the reliability of the wireless channel by providing replicas of the received signal. The simulation results show that GSM-STC achieves better performance compared to conventional GSM techniques in terms of data rate and BER, leading to good potential for massive MIMO by using subgroups of antennas.     

Assessment of Antioxidant and Anticancer Activities of Microgreen Alga Chlorella vulgaris and Its Blend with Different Vitamins

There is a very vital antioxidant extracted from microgreen alga. Chlorella vulgaris has major advantages and requires high yield worldwide. Some microalgae require vitamins for their growth promotion. This study was held to determine the impact of different vitamins including Thiamine (B1), Riboflavin (B2), Pyridoxine (B6), and Ascorbic acid (c) at concentrations of 0.02, 0.04, 0.06, and 0.08 mg/L of each. Each vitamin was added to the BG11 growth medium to determine the effect on growth, total carbohydrate, total protein, pigments content, antioxidant activities of Chlorella vulgaris. Moreover, antitumor effects of methanol extract of C. vulgaris without and with the supplement of thiamine against Human prostate cancer (PC-3), Hepatocellular carcinoma (HEPG-2), Colorectal carcinoma (HCT-116) and Epitheliod Carcinoma (Hela) was estimated in vitro. C. vulgaris supplemented with various vitamins showed a significant increase in biomass, pigment content, total protein, and total carbohydrates in comparison to the control. Thiamine was the best vitamin influencing as an antioxidant. C. vulgaris supplemented with thiamine had high antitumor effects in vitro. So, it’s necessary to add vitamins to BG11 media for enhancement of the growth and metabolites.     

Solid-phase intermolecular radical reactions 2: synthesis of C-glycopeptide mimetics via a novel acrylate acceptor

[reaction: see text] A novel tetrafluorophenol-linked acrylate is reported as an activated acceptor for intermolecular radical reactions. Addition of alkyl radicals led to pure products in good yields. We include here the first syntheses of C1- and C6-linked glycosides using a solid-phase radical methodology.     

Kinetic and mechanistic study on the reaction of alkylcobaloximes with azoles

The kinetics of axial water substitution by azoles (pyrazole and 1,2,4-triazole) in three different cobaloximes, viz.trans-[Co(Hdmg)(2)(R)H(2)O] where Hdmg = dimethylglyoximate, R = PhCH(2), Et and CF(3)CH(2), were studied as a function of azole concentration, temperature and pressure in aqueous solution. The second order rate constants for the substitution of water in trans-[Co(Hdmg)(2)(R)H(2)O] for R = Et at pH 6.0, 25 degrees C and I= 0.1 M (NaClO(4)), were found to be 1309 and 1200 M(-1) s(-1) for pyrazole (Pz) and 1,2,4-triazole (Tz), respectively, and those obtained for R = PhCH(2) were found to be 755 and 691 M(-1) s(-1), respectively. The second order rate constants in the case of R = CF(3)CH(2) were found to be 0.358 and 0.348 M(-1) s(-1) for Pz and Tz, respectively. The relative order of reactivity for the different alkyls being Et > PhCH(2) > CF(3)CH(2). The activation parameters (DeltaH([not equal]), DeltaS([not equal]) and DeltaV([not equal])) obtained for these reactions were found to be in the range of 65-87 kJ mol(-1), 24-47 J mol(-1) K(-1) and 2.5-7.7 cm(3) mol(-1), respectively. These data suggest that an I(d) substitution mechanism operates where the azoles participate in the transition state.