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951.
Formulation design of an oral, fast-disintegrating dosage form containing taste-masked particles of famotidine 总被引:1,自引:0,他引:1
Mizumoto T Tamura T Kawai H Kajiyama A Itai S 《Chemical & pharmaceutical bulletin》2008,56(7):946-950
A fast-disintegrating dosage form has been developed as a user-friendly formulation that disintegrates in the mouth immediately. Patients can take it without water like a liquid formulation. In this study famotidine taste-masking technology was applied to the new fast-disintegrating tablet in an attempt to produce a novel, taste-masked, fast-disintegrating tablet. Partial granulation was found to be an effective and practical way to address content uniformity, however, oral disintegration time tended to become longer as content uniformity improved. The disintegration time was improved considerably by controlling ambient humidity during the compression process (>50% RH). Furthermore, since the new fast-disintegrating technology made it possible to use low compression force, there was no change in the structure or dissolution rate of the taste-masked particles after compression. Therefore, this system can produce a taste-masked fast-disintegrating tablet with satisfactory attributes. 相似文献
952.
The exchange couplings in [{Dy(hfac)3}2Cu(dpk)2] and [{Dy(hfac)3}2Ni(dpk)2(py)2] (Hdpk = di-2-pyridyl ketoxime) were precisely evaluated by high-frequency electron paramagnetic resonance and pulsed-field magnetization studies, giving J(Dy-Cu)/kB = -0.126 K and J(Dy-Ni)/kB = +0.031 K. 相似文献
953.
Ikeda-Ohno A Hennig C Rossberg A Funke H Scheinost AC Bernhard G Yaita T 《Inorganic chemistry》2008,47(18):8294-8305
Electrochemical and complexation properties of neptunium (Np) are investigated in aqueous perchlorate and nitrate solutions by means of cyclic voltammetry, bulk electrolysis, UV-visible absorption, and Np L(III)-edge X-ray absorption spectroscopies. The redox reactions of Np(III)/Np(IV) and Np(V)/Np(VI) couples are reversible or quasi-reversible, while the electrochemical reaction between Np(III/IV) and Np(V/VI) is irreversible because they undergo structural rearrangement from spherical coordinating ions (Np(3+) and Np(4+)) to transdioxoneptunyl ions (NpO2(n+), n = 1 for Np(V) and 2 for Np(VI)). The redox reaction of the Np(V)/Np(VI) couple involves no structural rearrangement on their equatorial planes in acidic perchlorate and nitrate solutions. A detailed analysis on extended X-ray absorption fine structure (EXAFS) spectra suggests that Np(IV) forms a decaaquo complex of [Np(H2O)10](4+) in 1.0 M HClO4, while Np(V) and Np(VI) exist dominantly as pentaaquoneptunyl complexes, [NpO2(H2O)5](n+) (n = 1 for Np(V) and 2 for Np(VI)). A systematic change is observed on the Fourier transforms of the EXAFS spectra for all of the Np oxidation states as the nitrate concentration is increased in the sample, revealing that the hydrate water molecules are replaced by bidentate-coordinating nitrate ions on the primary coordination sphere of Np. 相似文献
954.
Silicon (Si), germanium (Ge), tin (Sn), and lead (Pb) clusters mixed with a group-4 transition metal atom [M = titanium (Ti), zirconium (Zr), and hafnium (Hf)] were generated by a dual-laser vaporization method, and their properties were analyzed by means of time-of-flight mass spectroscopy and anion photoelectron spectroscopy together with theoretical calculations. In the mass spectra, mixed neutral clusters of MSi(16), MGe(16), and MSn(16) were produced specifically, but the yield of MPb(16) was low. The anion photoelectron spectra revealed that MSi(16), MGe(16), and MSn(16) neutrals have large highest occupied molecular orbital-lowest unoccupied molecular orbital gaps of 1.5-1.9 eV compared to those of MPb(16) (0.8-0.9 eV), implying that MSi(16), MGe(16), and MSn(16) are evidently electronically stable clusters. Cage aromaticity appears to be an important determinant of the electronic stability of these clusters: Calculations of nucleus-independent chemical shifts (NICSs) show that Si(16)(4-), Ge(16)(4-), and Sn(16)(4-) have aromatic characters with negative NICS values, while Pb(16)(4-) has an antiaromatic character with a positive NICS value. 相似文献
955.
Centrifugal partition chromatography (CPC) was applied to separate amphiphilic glycolipids and pseudo-glycolipids synthesized by using cells. Neutral and acidic lipid fractions were isolated by CPC under suitable conditions respectively. Separation of neutral lipid, Gb3-type and Gb4-type oligosaccharide synthesized by using cells, was performed with a two-phase solvent system composed of chloroform-methanol-water at a volume ratio of 5:6:4. On the other hand, separation of acidic lipid, GM3-type oligosaccharide synthesized by using cells, and ganglioside extracted from rat brain were performed with a two-phase solvent system composed of butanol-ethanol-1% acetic acid at a volume ratio of 4:1:5. 8.3mg of Gb3 analogue, 5.1mg of Gb4 analogue, and 19.5mg of GM3 analogue were purified from 3.2l of culture medium obtained by incubation of African green-monkey kidney (Vero) cells with 50 microM n-dodecyl beta-lactoside using CPC. 相似文献
956.
Shirai A Miyata O Tohnai N Miyata M Procter DJ Sucunza D Naito T 《The Journal of organic chemistry》2008,73(12):4464-4475
The asymmetric total synthesis of martinellic acid, the first pyrrolo[3,2-c]quinoline alkaloid found in nature, is described. Three key steps in our synthesis of (-)-martinellic acid are the Bu(3)SnH-promoted radical addition-cyclization-elimination (RACE) reaction of an oxime ether with an alpha,beta-unsaturated ester to generate the pyrrolo[3,2-c]quinoline core, a chemoselective lactam carbonyl reduction, and guanidinylation under Mitsunobu reaction conditions. The key radical cyclization has also been investigated by using SmI(2). (-)-Martinellic acid was synthesized from commercially available methyl 4-bromo-3-methylbenzoate in fewer steps than previous syntheses and in an improved overall yield. 相似文献
957.
A. I. Titov Burkhard Kämpfer Atsushi Hosaka Hideaki Takabe 《Physics of Particles and Nuclei》2016,47(3):456-487
This work provides an overview of our recent results in studying two most important and widely discussed quantum processes: electron-positron pairs production off a probe photon propagating through a polarized short-pulsed electromagnetic (e.g. laser) wave field or generalized Breit–Wheeler process, and a single a photon emission off an electron interacting with the laser pules, so-called non-linear Compton scattering. We show that the probabilities of particle production in both processes are determined by interplay of two dynamical effects, where the first one is related to the shape and duration of the pulse and the second one is non-linear dynamics of the interaction of charged fermions with a strong electromagnetic field. We elaborate suitable expressions for the production probabilities and cross sections, convenient for studying evolution of the plasma in presence of strong electromagnetic fields. 相似文献
958.
Swelling and elution properties of physically crosslinked poly(vinyl alcohol) (PVA) cast gels depend on the network structure of the PVA and crosslink, which is characterized by the size, number, and distribution of microcrystallites. Therefore, the swelling and elution ratios can be manipulated by adept control of the conditions adopted for the preparation of gels. Among the various factors that influence the formation of microcrystallites, the temperature and relative humidity at gelation play an important role. In addition, the size of gel is also a key factor that determines the network structure of gels. To this end, this study quantitatively evaluates the macroscopic properties of swelling and elution, and the microscopic properties of the network structures in disk‐shaped PVA cast gels of the same diameter prepared by casting different weights of PVA solution in the same dish. Although the drying speed can be controlled by adjusting the three processing parameters, namely, drying temperature, humidity, and cast weight, the changes in swelling and elution ratios, microcrystallite size, and crystallinity independently depended on each parameter. Regardless of the three factors, the swelling ratio was found to correlate strongly with the elution ratio. Optimum factors to minimize the elution ratio are discussed on the basis of the change in the network structures obtained by varying the preparatory conditions. Based on the results of the systematic analyses, this study proposes a method to control the elution ratio while retaining high water‐absorbance ability. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
959.
Kobayashi T Yabushita A Saito T Ohtani H Tsuda M 《Photochemistry and photobiology》2007,83(2):363-368
By using a sub-5-fs visible laser pulse, we have made the first observation of the vibrational spectra of the transition state during trans-cis isomerization in the retinal chromophore of bacteriorhodopsin (bR(S68). No instant isomerization of the retinal occurs in spite of electron promotion from the bonding pi-orbital to the anti-bonding pi*-orbital. The difference between the in-plane and out-of-plane vibrational frequencies (about 1150-1250 and 900-1000 cm(-1), respectively) is reduced during the first time period. The vibrational spectra after this period became very broad and weak and are ascribed to a "silent state." The silent state lasts for 700-900 fs until the chromophore isomerizes to the cis-C13 = C14 conformation. The frequency of the C = C stretching mode was modulated by the torsion mode of the C13 = C14 double bond with a period of 200 fs. The modulation was clearly observed for four to five periods. Using the empirical equation for the relation between bond length and stretching frequency, we determined the transitional C = C bond length with about 0.01 angstroms accuracy during the torsion motion around the double bond with 1-fs time resolution. 相似文献
960.
Tatsuya Nabeshima Hayato Miyazaki Atsushi Iwasaki Shigehisa Akine Toshiyuki Saiki Chusaku Ikeda 《Tetrahedron》2007,63(16):3328-3333
On the basis of the concept of partial template, triangular trisaloph ligands 2a and 2b reacted with excess ZnII to give heptanuclear Zn clusters with a similar geometry. The Zn complex of 2c, which was difficult to be prepared according to a previous procedure, was synthesized in high yield in a one-pot fashion. Various multi-nuclear complexes of 2a with Mn, Co, Ni, and Cu were also produced, although the trinuclear MnII and CoII complexes were smoothly oxidized to the MnIII and CoIII complexes. 相似文献