CRYRING at the LSR at FLAIR

FLAIR will be the next-generation facility for physics with low-energy antiprotons, providing antiprotons at energies from tens of MeV down to rest. It will also offer unique possibilities for physics with highly charged ions at very low energies. The FLAIR facility will have two deceleration rings, the LSR which will decelerate antiprotons to 300 keV and the USR which will bring them down further to 20 keV. The LSR will consist of the present CRYRING at the Manne Siegbahn Laboratory. During the next few years, CRYRING will be modified with respect to injection and extraction, to allow injection of 30 MeV antiprotons and to provide it with both fast (single-turn) and slow (resonant) extraction at a variable energy. We here describe plans and preparations for the transfer of CRYRING to FLAIR, giving, in particular, an overview of new components for injection and extraction.     

Inviscid Limits¶of the Complex Ginzburg–Landau Equation

In the inviscid limit the generalized complex Ginzburg–Landau equation reduces to the nonlinear Schr?dinger equation. This limit is proved rigorously with H ¹ data in the whole space for the Cauchy problem and in the torus with periodic boundary conditions. The results are valid for nonlinearities with an arbitrary growth exponent in the defocusing case and with a subcritical or critical growth exponent at the level of L ² in the focusing case, in any spatial dimension. Furthermore, optimal convergence rates are proved. The proofs are based on estimates of the Schr?dinger energy functional and on Gagliardo–Nirenberg inequalities. Received: 2 April 1999 / Accepted: 29 March 2000     

A Versatile Preparation Route for Thin Free‐Standing Liquid Single Crystal Elastomers

Summary: Thin films of nematic and cholesteric side‐chain polymers containing reactive benzophenone units can be macroscopically oriented by electric/magnetic fields or surface interactions. After UV‐irradiation, liquid single crystal elastomers (LSCEs) are formed. With this simple, new pathway, macroscopically ordered free‐standing LSCE films are easily accessible having a thickness in the range of about 100 nm to 100 μm as outlined in Figure.

     

Asymptotic Analysis of a Semiconductor Model Based on Fermi–Dirac Statistics

The quasi-hydrodynamic carrier transport equations for semiconductors extended to Fermi–Dirac statistics are considered. It is shown that in the high injection case, these equations reduce to a drift-diffusion model with non-linear diffusion terms. The limiting procedure is proved rigorously and error estimates are shown. We compute numerically static voltage–current characteristics of a forward biased pn-junction diode and compare the curves with the corresponding characteristics obtained from the standard drift-diffusion model based on Boltzmann statistics. It turns out that there exists a so-called threshold voltage at which the behaviour of the characteristic changes. Under high injection conditions, the dependence of the current on the bias appears to be approximately polynomial. The characteristics are studied analytically for a unipolar device.     

Compound set enrichment: a novel approach to analysis of primary HTS data

The main goal of high-throughput screening (HTS) is to identify active chemical series rather than just individual active compounds. In light of this goal, a new method (called compound set enrichment) to identify active chemical series from primary screening data is proposed. The method employs the scaffold tree compound classification in conjunction with the Kolmogorov-Smirnov statistic to assess the overall activity of a compound scaffold. The application of this method to seven PubChem data sets (containing between 9389 and 263679 molecules) is presented, and the ability of this method to identify compound classes with only weakly active compounds (potentially latent hits) is demonstrated. The analysis presented here shows how methods based on an activity cutoff can distort activity information, leading to the incorrect activity assignment of compound series. These results suggest that this method might have utility in the rational selection of active classes of compounds (and not just individual active compounds) for followup and validation.     

Observation of highly flexible residues in amyloid fibrils of the HET-s prion

We report the observation of undetected (until now) residues of the prion protein fragment HET-s(218-289) which give rise to well-resolved (13)C, (15)N, and (1)H NMR resonances under high-resolution magic-angle spinning (HRMAS) conditions. The observed signals belong to large polymeric units as shown by measuring the lateral diffusion constants. The amino acids identified in the spectra are compatible with their localization in the segments of the protein which could not be detected in earlier solid-state NMR experiments. The observed chemical shifts indicate that these residues are in a random-coil conformation. Complementary experiments which detect only dynamic or static residues, respectively, strongly suggest that they belong to different parts of the same molecule.