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81.
A new linker cis-5-aminopent-3-enoic acid (cis-Apa) was prepared for the synthesis of cyclic pseudopeptides by cyclization-cleavage by using ring-closing methatesis (RCM). We developed a new synthetic pathway for the preparation of the cis-Apa linker that was tested in the cyclization-cleavage process of different RGD peptide sequences. Different macrocyclic peptidomimetics were prepared by using this integrated microwave-assisted method, showing that the readily available cis-Apa amino acid is well adapted as a linker in the cyclization-cleavage process. 相似文献
82.
Chevolot Y Zhang J Meyer A Goudot A Rouanet S Vidal S Pourceau G Cloarec JP Praly JP Souteyrand E Vasseur JJ Morvan F 《Chemical communications (Cambridge, England)》2011,47(31):8826-8828
The binding of seven multivalent glycoconjugates displaying linear or antenna-like structures and different electronic environments were evaluated towards PA-IL on a DNA-based carbohydrate microarray. The affinity can be modulated by the charge and the topology of the galactosylated derivatives. 相似文献
83.
84.
In this lecture notes, we will discuss the classical Aleksandrov-Fenchel inequalities for quermassintegrals on convex domains
and pose the problem of how to extend the inequalities to non-convex domains. We will survey some recent progress on the problem,
then report some of our joint work [9] in which we generalize the k-th stage of the inequalities to a class of (k + 1)-convex domains. Our proof, following the earlier work of Castillion [8] for k = 1 case of the inequalities, uses the method of optimal transport. 相似文献
85.
Giovanni Petrillo Cinzia Tavani Lara Bianchi Alice Benzi Maria Maddalena Cavalluzzi Lara Salvagno Laura Quintieri Annalisa De Palma Leonardo Caputo Antonio Rosato Giovanni Lentini 《Molecules (Basel, Switzerland)》2021,26(13)
Twenty-two novel, variously substituted nitroazetidines were designed as both sulfonamide and urethane vinylogs possibly endowed with antimicrobial activity. The compounds under study were obtained following a general procedure recently developed, starting from 4-nitropentadienoates deriving from a common β-nitrothiophenic precursor. While being devoid of any activity against fungi and Gram-negative bacteria, most of the title compounds performed as potent antibacterial agents on Gram-positive bacteria (E. faecalis and three strains of S. aureus), with the most potent congener being the 1-(4-chlorobenzyl)-3-nitro-4-(p-tolyl)azetidine 22, which displayed potency close to that of norfloxacin, the reference antibiotic (minimum inhibitory concentration values 4 and 1–2 μg/mL, respectively). Since 22 combines a relatively efficient activity against Gram-positive bacteria and a cytotoxicity on eucharyotic cells only at 4-times higher concentrations (inhibiting concentration on 50% of the cultured eukaryotic cells: 36 ± 10 μM, MIC: 8.6 μM), it may be considered as a promising hit compound for the development of a new series of antibacterials selectively active on Gram-positive pathogens. The relatively concise synthetic route described herein, based on widely available starting materials, could feed further structure–activity relationship studies, thus allowing for the fine investigation and optimization of the toxico-pharmacological profile. 相似文献
86.
An efficient Heck coupling of 2-hydroxy-3-iodo-naphthoquinone with a series of electron-deficient alkenes in aqueous solution has been accomplished. The method is characterized by simple conditions and facile work-up to isolate the products in good to excellent yields. The products contain the motif present in several naphthoquinone pigments but with enhanced polarity. 相似文献
87.
This paper presents a mixed-integer programming formulation to find optimal solutions for the block layout problem with unequal departmental areas arranged in flexible bays. The nonlinear department area constraints are modeled in a continuous plane without using any surrogate constraints. The formulation is extensively tested on problems from the literature. 相似文献
88.
We give a detailed analysis of the proportion of elements in the symmetric group on n points whose order divides m, for n sufficiently large and m≥n with m=O(n).
相似文献
89.
Adriana Vlez Feij Maria Alice Parente Mara Behlau Srgio Haussen Maria Cecília De Veccino Beatriz Castellar de Faria Martignago 《Journal of voice》2004,18(3):341-347
The objective is to investigate the presence of dysphonic symptoms in multiple sclerosis (MS) patients and to compare quantitative acoustic parameters in multiple sclerosis patients and normal individuals. The method of study was an 8-month controlled cross-sectional that was carried out with 106 individuals (30 MS, 76 controls). Both groups included males and females from 20 to 55 years. Exclusion criteria were prior vocal disorder, laryngeal microsurgery, recent endotracheal intubation, tumors, laryngeal, lung or mediastinal metastases, respiratory disease, and other associated neurological diagnoses. For dysphonic symptoms (qualitative variables), associations were assessed using Mantel-Haenszel's chi2 test, with Yates correction or the Fisher exact test when necessary. Statistical significance was set at p< or =0.05. Dysphonia was observed in 70% of MS individuals versus 33% of controls (p=0.01). Association was found between MS and dysphonia (OR: 2.2, CI 95%: 1.13-4.25). Fundamental frequency was higher among MS patients (p=0.01). Fundamental frequency deviation was significantly higher in MS women (but not men) than controls (p=0.00). Jitter was higher in MS men than in all other groups (p=0.00). Results suggest that evaluation and treatment of MS patients should be revised, evaluating voice alterations in relation to other signs. MS seems to intensify gender effect on fundamental frequency deviation, noise, and jitter, with MS women presenting fewer voice variations than men. 相似文献
90.
Andreas Dress Katharina T. Huber Alice Lesser Vincent Moulton 《Annals of Combinatorics》2006,10(1):63-76
One of the main problems in phylogenetics is to find good approximations of metrics by weighted trees. As an aid to solving this problem, it could be tempting to consider
optimal realizations of metrics—the guiding principle being that, the (necessarily unique) optimal realization of a tree metric is the weighted tree that realizes this metric. And, although optimal realizations of arbitrary metrics are, in general,
not trees, but rather weighted networks, one could still hope to obtain a phylogenetically informative representation of a
given metric, maybe even more informative than the best approximating tree. However, optimal realizations are not only difficult
to compute, they may also be non-unique. Here we focus on one possible way out of this dilemma: hereditarily optimal realizations. These are essentially unique, and can be described in a rather explicit way. In this paper, we recall what a hereditarily
optimal realization of a metric is and how it is related to the 1-skeleton of the tight span of that metric, and we investigate under what conditions it coincides with this 1-skeleton. As a consequence, we will show
that hereditarily optimal realizations for consistent metrics, a large class of phylogentically relevant metrics, can be computed in a straight-forward fashion.
Received August 26, 2004 相似文献