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排序方式: 共有428条查询结果,搜索用时 31 毫秒
421.
Rastegari Arezoo Safavi Maliheh Vafadarnejad Fahimeh Najafi Zahra Hariri Roshanak Bukhari Syed Nasir Abbas Iraji Aida Edraki Najmeh Firuzi Omidreza Saeedi Mina Mahdavi Mohammad Akbarzadeh Tahmineh 《Molecular diversity》2022,26(1):409-428
Molecular Diversity - Alzheimer’s disease (AD) is now ranked as the third leading cause of death after heart disease and cancer. There is no definite cure for AD due to the multi-factorial... 相似文献
422.
Sergei Boichuk Aigul Galembikova Kirill Syuzov Pavel Dunaev Firuza Bikinieva Aida Aukhadieva Svetlana Zykova Nazim Igidov Ksenia Gankova Maria Novikova Pavel Kopnin 《Molecules (Basel, Switzerland)》2021,26(19)
Microtubule targeting agents (MTAs) that interfere with the dynamic state of the mitotic spindle are well-known and effective chemotherapeutic agents. These agents interrupt the microtubule network via polymerization or depolymerization, halting the cell cycle progression and leading to apoptosis. We report two novel pyrrole-based carboxamides (CAs) (CA-61 and -84) as the compounds exhibiting potent anti-cancer properties against a broad spectrum of epithelial cancer cell lines, including breast, lung, and prostate cancer. The anti-cancer activity of CAs is due to their ability to interfere with the microtubules network and inhibit tubulin polymerization. Molecular docking demonstrated an efficient binding between these ligands and the colchicine-binding site on the tubulin. CA-61 formed two hydrogen bond interactions with THR 179 (B) and THR 353 (B), whereas two hydrogen bonds with LYS 254 (B) and 1 with ASN 101 (A) were identified for CA-84. The binding energy for CA-84 and CA-61 was −9.910 kcal/mol and −9.390 kcal/mol. A tubulin polymerization assay revealed a strong inhibition of tubulin polymerization induced by CA-61 and -84. The immunofluorescence data revealed the disruption of the tubulin assembly in CA-treated cancer cells. As an outcome of the tubulin inhibition, these compounds halted the cell cycle progression in the G2/M phase, leading to the accumulation of the mitotic cells, and further induced apoptosis. Lastly, the in vivo study indicated that CAs significantly inhibited the HCC1806 breast cancer xenograft tumor growth in a nude mouse model. Collectively, we identified the novel CAs as potent MTAs, inhibiting tubulin polymerization via binding to the colchicine-binding site, disrupting the microtubule network, and exhibiting potent pro-apoptotic activities against the epithelial cancer cell lines both in vitro and in vivo. 相似文献
423.
Shau Mien Ng Shin-ichi Ogino Takuzo Aida Keiko A. Koyano Takashi Tatsumi 《Macromolecular rapid communications》1997,18(12):991-996
Free radical polymerization of methyl methacrylate (MMA) within the uniform channels of the mesoporous zeolite MCM-41 proceeds at 100°C to give a high molecular weight polymer (PMMA). The formation of long-living propagating polymer-radicals is observed by electron paramagnetic resonance (EPR). The molecular weight of PMMA within the mesopores can be controlled over a wide range by changing the monomer-to-initiator mole ratio. 相似文献
424.
2,2′‐Methylenebis(6‐tert‐butyl‐4‐methylphenolate) titaniumdichloride ( 1 a ) brought about the living polymerization of 1,3‐dioxepan‐2‐one (7CC) to give polymers with narrow molecular weight distributions. The molecular weight of the obtained polycarbonate could be controlled by changing the initial mole ratio of 7CC and 1 a . The polycarbonate thus formed has hydroxymethylene terminal units at both ends. 相似文献
425.
Hao K. Shen Kiyoshi Morishita Dr. P. K. Hashim Prof. Dr. Kou Okuro Daiki Kashiwagi Ayumi Kimura Dr. Haruaki Yanagisawa Prof. Dr. Masahide Kikkawa Prof. Dr. Tatsuya Niwa Prof. Dr. Hideki Taguchi Prof. Dr. Takuzo Aida 《Angewandte Chemie (International ed. in English)》2023,62(31):e202304894
Herein, we report an ATP-responsive nanoparticle (GroELNP) whose surface is fully covered with the biomolecular machine “chaperonin protein GroEL”. GroELNP was synthesized by DNA hybridization between a gold NP with DNA strands on its surface and GroEL carrying complementary DNA strands at its apical domains. The unique structure of GroELNP was visualized by transmission electron microscopy including under cryogenic conditions. The immobilized GroEL units retain their machine-like function and enable GroELNP to capture denatured green fluorescent protein and release it in response to ATP. Interestingly, the ATPase activity of GroELNP per GroEL was 4.8 and 4.0 times greater than those of precursor cysGroEL and its DNA-functionalized analogue, respectively. Finally, we confirmed that GroELNP could be iteratively extended to double-layered NP. 相似文献
426.
The copolymerization of oxetane with glutaric anhydride was found to proceed with bulky titanium bisphenolate ( 1 ) as the initiator. The 1H NMR spectrum of the produced copolymer shows that the copolymer contains both alternating units and oxytrimethylene units in the polymer main chain. 1 was also effective for the copolymerization of oxetane with other cyclic acid anhydrides, affording the corresponding copolymers. With the titanium bisalkolate complex ( 4 ), a copolymer rich in alternating sequences was obtained. 相似文献
427.
Vladimir I. Bakhmutov Aida Contreras-Ramirez Hannah Drake Hong-Cai Zhou 《Magnetic resonance in chemistry : MRC》2023,61(1):16-21
The phosphorus chemical shift anisotropies, 31PΔcs, and asymmetry parameters η were measured by the 31P{1H} NMR experiments in static and low-frequency spinning samples of the zirconium phosphates and phosphonates and also in the mixed Zr (IV)/Sn (IV) phosphate/phosphonate material. The data obtained have shown a 111 connectivity in the HPO4 and PO3 groups, which does not change at modification and intercalation of the materials. The 31PΔcs values of the phosphonate groups (43–49 ppm) significantly surpass the values characterizing the HPO4 groups (23–37 ppm). The 31P Δcs values obtained for the metal (IV) phosphates were discussed in terms of P-O distances. The 31P chemical shift anisotropy parameters can help at elucidation of local structures in phosphate and phosphonate materials. 相似文献
428.
Shohei Inoue Takuzo Aida Masashi Kinugawa Masanori Isoda Daisuke Takeuchi 《Macromolecular Symposia》1995,98(1):163-170
Metalloporphyrin initiator coupled with an appropriate organometallic Lewis acid catalyst could make possible the first example of living anionic polymerization of oxetane. Lewis acid built-in metalloporphyrins were designed as a new highly active catalyst/initiator system. The concept of monomer activation by Lewis acid was extended to the use of appropriate protonic acid. 相似文献