Design,Synthesis, Biological Evaluation,and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors

A novel series of tri-aryl imidazole derivatives 5a–n carrying benzene sulfonamide moiety has been designed for their selective inhibitory against hCA IX and XII activity. Six compounds were found to be potent and selective CA IX inhibitors with the order of 5g > 5b > 5d > 5e > 5g > 5n (Ki = 0.3–1.3 μM, and selectivity ratio for hCA IX over hCA XII = 5–12) relative to acetazolamide (Ki = 0.03 μM, and selectivity ratio for hCA IX over hCA XII = 0.20). The previous sixth inhibitors have been further investigated for their anti-proliferative activity against four different cancer cell lines using MTT assay. Compounds 5g and 5b demonstrated higher antiproliferative activity than other tested compounds (with GI₅₀ = 2.3 and 2.8 M, respectively) in comparison to doxorubicin (GI₅₀ = 1.1 M). Docking studies of these two compounds adopted orientation and binding interactions with a higher liability to enter the active side pocket CA-IX selectively similar to that of ligand 9FK. Molecular modelling simulation showed good agreement with the acquired biological evaluation.     

Transverse Vibrations of a Centrally Clamped Rotating Circular Disk

The transverse vibrations of a circular disk of uniform thickness rotatingabout its axis with constant angular velocity are analyzed. The resultsspecialized to the linear case of disks clamped at the center and free atthe periphery are in good agreement with those reported in the literature.The natural frequencies of spinning hard and floppy disks are obtained for various nodal diameters and nodal circles. Primary resonance is shown to occur at the critical rotational speed at which, in the linear analysis, the spinning disk is unable to support arbitraryspatially fixed transverse loads. Using the method of multiple scales, wedetermine a set of four nonlinear ordinary-differential equations governingthe modulation of the amplitudes and phases of two interacting modes. Thesymmetry of the system and the loading conditions are reflected in thesymmetry of the modulation equations. They are reduced to an equivalentset of two first-order equations whose equilibrium solutions aredetermined analytically. The stability characteristics of thesesolutions is studied; the qualitative behavior of the response isindependent of the mode being considered.     

Design,synthesis, and characterization of novel pyrimidines bearing indole as antimicrobial agents

Pyrimidines and pyrimidine bearing indole derivatives are very important species in organic chemistry due to their wide use as bioactive compounds with a broad range of good biological activities. Due to the wide spread of different species of bacteria and fungi nowadays, in the present work, a novel series of indolyl‐pyrimidines (2–13) were synthesized starting from 3‐chloro‐1H‐indole‐2‐carbaldehyde (1) . Elemental analysis, IR, 1H‐NMR, 13C‐NMR, and mass spectral data elucidated the structure of newly synthesized compounds. All compounds were screened for their in vitro antibacterial and antifungal activity, and they demonstrated promising results; all the new compounds synthesized from compound (1) , which allowed reactions with thiourea and ethyl cyanoacetate, gave the target compound (2) , which was used as a precursor for the synthesis of indolylthiazolopyrimidine derivatives (3–8) by reactions with halocarbonyl compounds such as chloroacetone, phancyl bromide, and chloroacetic acid through alkylation of the mercapto group followed by cyclization through a nucleophilic attack. When compound (2) subjected to react with hydrazine hydrate gave 4‐indolyl‐2‐hydrazinopyrimidine (5) , the latter compound, when allowed to react with ethyl chloroacetate or diethyloxalate, gave indolylpyrimidotriazine derivatives (10 , 11) ; in contrast, when the compound reacted with acetic anhydride or formic acid, it gave triazolopyrimidine derivatives (12, 13) .     

Structural,morphological, optical and dielectric properties of M3+/PVA/PEG SPE Films (M = La,Y, Fe or Ir)

Low band gap polymer complexes are promising due to its flexibility, and exhibiting electronic and optical properties of inorganic semiconductors. The effect of PEG on the physical properties of PVA was evaluated. Then, blend (PVA: PEG = 50:50) doped with rare earth (La or Y) and transition metal (Fe or Ir) chlorides to obtain solid polymer electrolyte films. XRD shows that adding PEG to PVA results in a new peak, 2θ = 23^o with increased intensity as PEG ratio increases. However, doping with La³⁺, Fe³⁺ or Ir³⁺ eliminate this peak and decrease the crystallinity. SEM exhibits significant changes in the morphology of films. FTIR confirms miscibility between PVA & PEG and the complexation of the salts. The optical band gap (E_g) of PVA ~ 5.37 eV, decreased slightly by blending with PEG. While it decreased significantly to 2.64 eV and 2.78 eV after doping with Fe³⁺ or Ir³⁺. There are a consistency between E_g values obtained by Tauc's model and that obtained from the optical dielectric loss. The dielectric constant and loss, in temperature range 303–405 K & frequency range 1.0 kHz ‐ 5.0 MHz, indicate one or two relaxation peak(s) depending on the film composition. Accordingly, conduction mechanism varied between correlated barrier hopping and large polaron tunneling. The DC conductivity was strongly depend on the dielectric loss. The transition metal salts appear to be more effective than the rare earth ones in increasing σ_ac of films to higher values that candidates them in semiconductors industry.     

Heat transfer from rotating finned heat exchangers with different orientation angles

The local and average heat transfer characteristics of spoke like fins that extend outward from a rotating shaft have been determined experimentally. The experiments encompassed a number of geometrical parameters, including the length and chord of the fins, the number of fins deployed around the circumference of the shaft and the orientation angles of the fin. The experiments cover a wider range of rotational speeds, which varies from 25 up to 2,000 rpm. Three wire heat flux sensors have been used in conjunction with a slip ring apparatus to evaluate the local and average heat transfer coefficients. The output results indicated that, the heat transfer transition on rotating fins occurs at Reynolds number lower than encountered on the stationary rectangular fins in crossflow. In general, with non zero incidence angle, the rotating system acts as a fan and creates axial air motion, which enhance the heat transfer rate. However, the effect of orientation angle reduces with increasing the rotational speed. The Nusselt number data are independent of the number of fins in the circumferential array at high rotational speed and are weakly dependent at low Reynolds numbers. To facilitate the use of the results for design, correlations were developed which represent the fin heat transfer coefficient as a continuous function of the investigated independent parameters.     

有序介孔磷酸钛锂离子电池正极材料制备及电化学性能

选用合适模板剂由溶胶凝胶法合成高度有序介孔结构的磷酸钛正极材料.研究煅烧温度对材料孔结构及材料的电化学性能的影响,合成样品的结构形貌和比表面分别用XRD、BET、TEM及元素分析仪表征.充放电测试结果表明,该介孔结构正极材料表现出优越的电化学性能,以150 mA/g充放电,首次放电容量高达94 mAh/g,而不含模板剂无孔结构的材料放电容量仅37 mAh/g.     

Inverse full state hybrid projective synchronization for chaotic maps with different dimensions

A new synchronization scheme for chaotic(hyperchaotic) maps with different dimensions is presented.Specifically,given a drive system map with dimension n and a response system with dimension m,the proposed approach enables each drive system state to be synchronized with a linear response combination of the response system states.The method,based on the Lyapunov stability theory and the pole placement technique,presents some useful features:(i) it enables synchronization to be achieved for both cases of n m and n m;(ii) it is rigorous,being based on theorems;(iii) it can be readily applied to any chaotic(hyperchaotic) maps defined to date.Finally,the capability of the approach is illustrated by synchronization examples between the two-dimensional H′enon map(as the drive system) and the three-dimensional hyperchaotic Wang map(as the response system),and the three-dimensional H′enon-like map(as the drive system) and the two-dimensional Lorenz discrete-time system(as the response system).     

Entanglement Generation Between Two Mechanical Resonators in Two Optomechanical Cavities

A standard model is suggested to explore correlation features of two spatially separated optomechanical cavities. The cavities are coupled through the photon-hopping process. In particular, we investigate the generation of entanglement between mechanical resonators in the strong coupling regime and the two cavities are assumed to be driven by a coherent laser field. In order to quantify entanglement we use the logarithmic negativity. The analytical solutions are presented for the system in a parameter regime very close to the current experimental results. We show that in the presence of the photon hopping process between the cavities, the two mechanical resonators and the field modes can be entangled. This shows clearly that the entanglement can be transfer via radiation pressure of a photon hopping coupling from the intracavity photon-phonon entanglements to an inter-cavity photon-photon or phonon-phonon entanglement.     

Carboxylation and esterification of functionalized arylcopper reagents

Functionalized arylcopper reagents have been produced in good yields at 25 degrees C from activated copper and the corresponding functionalized aryl iodides without the need of traditional organolithium or Grignard precursors. These organocopper compounds will undergo carboxylation with CO(2) to form the corresponding copper benzoates. In turn, these salts can be acidified to produce the functionalized aryl acids or treated with appropriate alkyl halides in the presence of a dipolar aprotic solvent to generate the corresponding aryl esters. This methodology permits the formation of functionalized organic acids and esters that could not be generated by the carboxylation of organomagnesium compounds.     

Reaction of nitrilimines and nitrile oxides with hydrazines, hydrazones and oximes

This review article discusses the reaction of nitrilimines and nitrile oxides with hydrazines, hydrazones, and oximes. Three reaction modes were observed. The article mainly covers our work published over the last fifteen years, in which interesting heterocyles such as oxadiazoles, triazoles, and tetrazines were synthesized and fully characterized.