2-[4-(2-Thienyl)-1,3-thiazol-2-yl]ethanenitrile in Heterocyclic Synthesis of Biological Interist

Abstract

Thiazolylacetonitrile was used in the synthesis of coumarin, pyrazolo[4,3]pyrimidines, 1,3,4-thiadiazolines, aminothiophenes, and thiazoles in a good yields. Also, pyrazolo[4,5-d]triazolino[4,5-a]pyrimidines, pyrazolo[4,5-d]thiazolino[3,2-a]pyrimidines, and pyrazolo[4,5-d]tetrazolino[1,5-a]pyrimidines were synthesized from pyrazolo[4,5-d]pyrimidine. Structures of the newly synthesized were elucidated by elemental analysis, spectral data, and alternative synthesis routes whenever possible. Some synthesized compounds were tested for their antimicrobial activity.     

Reactions of Hydrazonoyl Halides 41: 1 Synthesis of 1,2,4-Triazoles, 2,3-Dihydro-1,3,4-thiadiazoles,and Triazolo[4, 3-a]pyrimidines

Triazoles, thiadiazoles, and triazolo[4, 3-a]pyrimidines were synthesized via reaction of hydrazonoyl halides with each of 3-methyl-4-(methylthiothioxomethyl)-2-pyrazolin-5-one, 3-methyl-4-[methylthio(phenylamino)methyl]-2-pyrazolin-5-one, and pyrimidine-2-thiones. Structures of the newly synthesized compounds were elucidated on the basis of elemental analysis, spectral data, and alternative-methods synthesis whenever possible.     

Strontium hexabromodicadmate(II) octahydrate

The ternary system SrBr₂–CdBr₂–H₂O was investigated at room temperature. The title phase, SrCd₂Br₆·8H₂O, has been isolated from this system and its structure determined by single‐crystal X‐ray diffraction. The structure consists of infinite double chains of CdBr₆ octahedra and chains of Sr(H₂O)₉ polyhedra packed along the b axis. The interaction between these two isolated chains occurs through O—H⃛O and O—H⃛Br hydrogen bonds. The structure is compared with that of SrCd₂Cl₆·8H₂O.     

Synthesis of 2,3-dihydro-1,3,4-thiadiazole,thiazole, and triazolo[4,3-a]pyrimidine derivatives from ethyl benzoylacetate

Thiophene and thiazole derivatives can be obtained from potassium salt of ethyl 3-oxo-3-phenyl-2-[(phenylamino)thioxomethyl]propanoate and ethyl chloroacetate in N,N-dimethylformamide solution under different conditions. 2,3-Dihydro-1,3,4-thiadiazoles and triazolo[4,3-a]pyrimidine were obtained from reaction of hydrazonoyl halides with each of thioanilide and pyrimidine-2-thione, respectively. Structures of the newly synthesized compounds were elucidated on the basis of elemental analysis, spectral data, and alternative synthesis route whenever possible. © 2004 Wiley Periodicals, Inc. Heteroatom Chem 15:107–113, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10222