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31.
Hiroto Murakami Keisuke Futashima Minoru Nanchi Shin’ichiro Kawahara 《European Polymer Journal》2011,(3):378-384
An acrylic pressure-sensitive adhesive (PSA), bearing octadecyl acrylate, methyl acrylate and acrylic acid groups, and crosslinked by aluminum acetylacetonate (AlACA), displayed behavior unique among acrylic PSAs in that its adhesion, which decreases with an increase in temperature, began to increase again from around 150 °C. In order to understand this behavior, the structure and thermal properties of the PSA were investigated in detail, along with another PSA crosslinked by a covalent crosslinking agent (Az). From thermal mechanical analysis, the PSA with ionic crosslinks (AlACA) showed three softening points at 20, 60, and 160 °C. In comparison, the PSA covalently crosslinked by Az only exhibited two softening points (at 20 and 60 °C). The softening point at 160 °C is clearly related to ionic chelate crosslinking. DSC measurements indicated that the softening point at 20 °C resulted from melting of the ordered octadecyl group, and the softening point at 60 °C was due to an increase in the mobility of the main chain. The temperature dependence of viscoelastic measurements revealed that the viscosity of the PSA crosslinked by AlACA increased at around 160 °C. From these results, we considered that the distinctive adhesion of the PSA crosslinked by AlACA could be due to ligand exchange at the aluminum crosslinking points, which are chelated by carboxy groups built in the main chain. 相似文献
32.
Masumi Torii Yuki Hitora Hikaru Kato Yuhei Koyanagi Teppei Kawahara Fitje Losung Remy E.P. Mangindaan Sachiko Tsukamoto 《Tetrahedron》2018,74(52):7516-7521
Four new sulfonated serinol derivatives, siladenoserinols M–P (1–4), were isolated from a tunicate of the family Didemnidae collected in Indonesia. Their chemical structures were elucidated by the interpretation of NMR and mass spectroscopic data. Two of them (2 and 4) were revealed to be disulfonate serinol derivatives, and the others were monosulfonates. Siladenoserinols A (5) and B (6), which we previously isolated from the same tunicate, inhibited the p53–Hdm2 interaction with an IC50 value of 2.0?μM. However, 1–4 did not inhibit the activity. The result suggested that the acetyl group in the bicyclic ketal unit and/or the glycerophospholipid moiety in 5 and 6 were responsible for the inhibition of the p53–Hdm2 interaction. 相似文献
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A facile method for the construction of an immunoconjugate which displays targeting ligands, such as antibody fragments, with a high density is reported. For this purpose, we synthesized a novel trifunctional crosslinking reagent. By the use of this reagent, ligands targeting the specific cell can be displayed on the surface of the drug carrier with a high density. In this study, we display HER2 (human epidermal growth‐factor receptor‐2) binding ligands on branched polyethylenimine (PEI), which can form polyplexes with plasmid DNA. Kinetic analysis of the binding to the extracellular domain of HER2 show the PEI displaying a high density of ligands binds to the target more strongly compared to the PEI displaying ligands at a low density. The increased density of HER2 ligands displayed on the gene carrier contributes to the improved transfection efficiency. This approach can be applied to other drug delivery systems, including liposome, micelle, and so on. 相似文献
36.
T. Kawahara M. Miyazaki A. Kimura Y. Okamoto J. Morimoto T. Miyakawa 《Applied Physics A: Materials Science & Processing》1999,69(3):343-346
The noncontact imaging of the buried structures is carried out in the open-air atmosphere by using the photothermal deflection
(PTD) method. We applied these techniques to the layered samples. Besides the PTD images for the optically opaque buried structures,
the parameters of the materials such as thermal diffusivity can also be calculated from the PTD amplitude and phase signal
in the PTD scanning images. When the PTD signals at two different modulation frequencies are used, the thermal diffusivity
of the buried structure can be obtained from the PTD signal outside of the sample nondestructively.
Received: 27 November 1998 / Accepted: 18 March 1999 / Published online: 7 July 1999 相似文献
37.
The 7-endo Friedel-Crafts cyclization of arylpropyl vinyloxiranes was found to proceed regio- and stereoselectively to afford polyfunctional seven-membered carbocycles in excellent yields. 相似文献
38.
The enantiomeric resolution of N-t-butyloxycarbonyl (N-t-Boc) amino acids D/L isomers by reversed-phase HPLC was investigated using cyclodextrins (CD's) as chiral selectors for the mobile phase. The use of a low pH (pH<4) for the mobile phase enabled the enantioseparation of N-t-Boc amino acids. The opposite elution order of D/L isomers was observed when hydroxypropyl-derivatized beta-CD was used instead of native beta-CD. A computer simulation of the enantioseparation showed that the ratio of the retention factors of the chiral selector and the sample determined the elution order and the resolution. When the retention factor of the chiral selector is smaller than that of the sample, an isomer having larger complex formation constant eluted faster. However, when the chiral selector had a larger retention factor than the sample, an opposite elution order of the isomers was obtained. The large difference in the retention factors between the chiral selector and the sample led to good enantiomeric separation. 相似文献
39.
We quantitatively estimate the effect of spontaneous Raman scattering on a quantum channel wavelength-multiplexed with a classical channel. Based on an experiment that measured the generation power of spontaneous Raman scattering in a fiber, the performance of wavelength-multiplexed quantum key distribution (QKD) systems using the differential-phase-shift protocol is evaluated for various system conditions. 相似文献
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