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51.
Margaret M. Robins S. Jane Scarll Pauline E. Key 《Accreditation and quality assurance》2006,11(5):214-223
During the last decade, it has become increasingly important that researchers demonstrate that research is conducted to the highest standards. The implementation of quality assurance for research laboratories will enable all fields of research and development to be judged impartially. There are no specific standards for research laboratories but where possible, existing standards can be adapted. This review is structured around two approaches. The first considers research to be a logical extension of testing, and it is assumed that testing standards can be applied methodically to each step in a research project. The second advocates a flexible approach, with research-specific criteria for assessing quality. The important papers published on this topic have been reviewed. The conclusions are that the general quality management approach, encompassed by the ISO 9000 series of standards with the emphasis on customer satisfaction and ‘fitness for purpose’, is suitable for implementing quality assurance in research laboratories. 相似文献
52.
M. Scott Goodman Margaret A. Goodman Andrey Y. Kovalevsky Alexander Y. Nazarenko Donald Pope 《Acta Crystallographica. Section C, Structural Chemistry》2006,62(2):m30-m32
The title copper(II) complex, [Cu(C22H18N6)2](ClO4)2·2C2H3N, comprises two neutral substituted tris(pyrazol‐1‐yl)methane ligands bonded to a central CuII ion, which is positioned on a crystallographic inversion center. Six Cu—N bonds are arranged in a distorted octahedral fashion. The unsubstituted pyrazole rings on each ligand are oriented trans with respect to each other, interdigitated with the two 3‐phenylpyrazole rings of the other ligand. 相似文献
53.
Sadowsky JD Schmitt MA Lee HS Umezawa N Wang S Tomita Y Gellman SH 《Journal of the American Chemical Society》2005,127(34):11966-11968
Molecules that bind to specific surface sites on proteins are of great interest from both fundamental and practical perspectives. We are exploring a ligand development strategy that is based on oligomers with discrete folding propensities ("foldamers"); we target a specific cleft on the cancer-associated protein Bcl-xL because this system is well characterized structurally. In vivo, this cleft binds to alpha-helical segments (BH3 domains) of other proteins. We evaluated several types of helical foldamer, built entirely from beta-amino acid residues or from mixtures of alpha- and beta-amino acid residues, and ultimately identified foldamers in the latter class that bind very tightly to Bcl-xL. Our results suggest that combining different types of foldamer backbones will be an effective and general strategy for creating high-affinity and specific ligands for protein surface sites. 相似文献
54.
Urathamakul T Beck JL Sheil MM Aldrich-Wright JR Ralph SF 《Dalton transactions (Cambridge, England : 2003)》2004,(17):2683-2690
Electrospray ionisation mass spectrometry was used to investigate reactions between six ruthenium compounds and three different non self-complementary duplex oligonucleotides containing 16 base pairs. Each of the compounds studied formed non-covalent complexes containing between one and five ruthenium molecules bound to DNA. Competition experiments involving duplex 16mers and pairs of ruthenium compounds were used to determine the order of relative binding affinities of the metal compounds. Other competition experiments involving ruthenium compounds, and the organic DNA binding agents daunomycin and distamycin, provided information about the sites and modes of DNA binding of the ruthenium compounds. 相似文献
55.
Margaret M. Harding Ulrich Koert Jean-Marie Lehn Annie Marquis-Rigault Claude Piguet Jay Siegel 《Helvetica chimica acta》1991,74(3):594-610
A general strategy for the synthesis of oligobipyridine ligands 2 – 5 containing from two to five 2,2′-bipyridine subunits, for helical metal complexes is described (sec Scheme). Both the unsubstituted parent strands ( a series) as well as their derivatives bearing fester or amide functions in the 4,4′-positions of the bipyridine moieties ( b – d series) have been obtained. 相似文献
56.
Journal of Optimization Theory and Applications - Coordinate descent algorithms are popular in machine learning and large-scale data analysis problems due to their low computational cost iterative... 相似文献
57.
Simon A. Butler Gillian W. Harris David S. Moss Beatrice A. Gorinsky Margaret J. Adams Sheila Gover 《Journal of chemical crystallography》1994,24(1):1-3
We report the estimation of random errors in the refinement of the rigid body displacements of the -helices of the enzyme 6-phosphogluconate dehydrogenase. Least-squares refinement of the TLS parameters of the helices has been carried out using X-ray reflection data of 2.1 Å resolution, resulting in anR-factor of 19.5%. Standard deviations were estimated from the normal matrix. The results show that the translational mean-square displacements of nearly all the helices are significant at this resolution. However the libration parameters are only significant when the helices have at least four turns. Screw-rotation tensor values cannot be determined at this resolution. 相似文献
58.
Given any family of graphsP, theP chromatic number
p
(G) of a graphG is the smallest number of classes into whichV(G) can be partitioned such that each class induces a subgraph inP. We study this for hereditary familiesP of two broad types: the graphs containing no subgraph of a fixed graphH, and the graphs that are disjoint unions of subgraphs ofH. We generalize results on ordinary chromatic number and we computeP chromatic number for special choices ofP on special classes of graphs.Research supported in part by ONR Grant N00014-85K0570 and by a grant from the University of Illinois Research Board. 相似文献
59.
60.
C. Duyar J. E. Draper E. C. Rubel M. A. Deleplanque R. M. Diamond F. S. Stephens E. M. Beck M. A. Stoyer 《Zeitschrift für Physik A Hadrons and Nuclei》1994,348(1):63-64
117Te has been studied via82Se(40Ar,5n)117Te, and a new, substantially extended level scheme is proposed to I53/2. Our TRS calculations suggest rotational bands, but with an experimental sensitivity of 2%, we see none. Our results differ from those of Sharma, et al, who report two isolated E2 bands. We find them less band-like, being joined at the top and changed in content and order. We suggest a noncollective oblate shape for a new 39/2– level.This work is supported in part by the Department of Energy under Contract No.DE-AC03-76SF0098(LBL). 相似文献