High‐Resolution Hydrogen Spectroscopy and The Proton Radius Puzzle

High resolution spectroscopy of the hydrogen atom takes on particular importance in the new SI, as it allows to accurately determine fundamental constants, such as the Rydberg constant and the proton charge radius. Recently, the second most precisely measured transition frequency in hydrogen, $1S?3S$, is obtained by our group. In the context of the Proton Radius Puzzle, this result calls for further investigation.     

Finite Alternation Theorems and a Constructive Approach to Piecewise Polynomial Approximation in Chebyshev Norm

Set-Valued and Variational Analysis - One of the purposes in this paper is to provide a better understanding of the alternance property which occurs in Chebyshev polynomial approximation and...     

Littlewood-Paley Decomposition of Operator Densities and Application to a New Proof of the Lieb-Thirring Inequality

The goal of this note is to prove an analogue of the Littewood-Paley decomposition for densities of operators and to use it in the context of Lieb-Thirring inequalities.     

Activity of trioxaquine PA1259 in mice infected by Schistosoma mansoni

Schistosomiasis is a chronic life-threatening parasitic disease concerning more than 200 million people in the World. Little attention has been paid to schistosomiasis over the last 30 years, and praziquantel is the only drug in use to control this disease. In the absence of a vaccine, there is a real need for new drugs in order both to improve the efficacy of the treatment and to delay the development of praziquantel resistant schistosomes. The present note reports the significant reduction of the worm burden after oral administration of trioxaquine PA1259 to mice infected by Schistosoma mansoni.     

The PELskin project—part I: fluid–structure interaction for a row of flexible flaps: a reference study in oscillating channel flow

Previous studies of flexible flaps attached to the aft part of a cylinder have demonstrated a favourable effect on the drag and lift force fluctuation. This observation is thought to be linked to the excitation of travelling waves along the flaps and as a consequence of that, periodic shedding of the von Kármán vortices is altered in phase. A more general case of such interaction is studied herein for a limited row of flaps in an oscillating flow; representative of the cylinder case since the transversal flow in the wake-region shows oscillating character. This reference case is chosen to qualify recently developed numerical methods for the simulation of fluid–structure interaction in the context of the EU funded ‘PELskin’ project. The simulation of the two-way coupled dynamics of the flexible elements is achieved via a structure model for the flap motion, which was implemented and coupled to two different fluid solvers via the immersed boundary method. The results show the waving behaviour observed at the tips of the flexible elements in interaction with the fluid flow and the formation of vortices in the gaps between the flaps. In addition, formation of vortices upstream of the leading and downstream of the trailing flap is seen, which interact with the formation of the shear-layer on top of the row. This leads to a phase shift in the wave-type motion along the row that resembles the observation in the cylinder case.     

Tuning the C/N Ratio of C-Rich Graphitic Carbon Nitride (g-C3N4) Materials by the Melamine/Carboxylic Acid Adduct Route

C-rich graphitic carbonitride materials (CN_x) with a large range of compositions have been prepared thanks to the self-assembly, in different ratios, of melamine (M) and a panel of polycarboxylic acids (A) such as oxalic, tartaric and citric acid. The thermal conversion of the formed adducts (MA_y), led to CN_x phases, with x ranging from 0.66 to 1.4 (x=1.33 for g-C₃N₄ for comparison). The properties of these materials were examined by different techniques (XRD, Raman spectroscopy, TEM, TGA, XPS and DRIFT). It appears that the increase in the C content is associated with the disappearance of the long-range order of heptazine units and an increase in the sub-nanometer carbon-rich cluster size within the graphitic g-C₃N₄ structure. This trend is followed by a significant increase in the interlayer spacing and a lower proportion of N=C−N bonds compared to C=C bonds. The thermal stability under an inert atmosphere of these phases and their UV-Visible absorbance properties were also investigated.     

The SAMPL6 SAMPLing challenge: assessing the reliability and efficiency of binding free energy calculations

Journal of Computer-Aided Molecular Design - Approaches for computing small molecule binding free energies based on molecular simulations are now regularly being employed by academic and industry...