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71.
Solid lipid nanoparticles (SLNs) have the potential to enhance the systemic availability of an active pharmaceutical ingredient (API) or reduce its toxicity through uptake of the SLNs from the gastrointestinal tract or controlled release of the API, respectively. In both aspects, the responses of the lipid matrix to external challenges is crucial. Here, we evaluate the effects of lyophilization on key responses of 1:1 beeswax–theobroma oil matrix SLNs using three model drugs: amphotericin B (AMB), paracetamol (PAR), and sulfasalazine (SSZ). Fresh SLNs were stable with sizes ranging between 206.5–236.9 nm. Lyophilization and storage for 24 months (4–8 °C) caused a 1.6- and 1.5-fold increase in size, respectively, in all three SLNs. Zeta potential was >60 mV in fresh, stored, and lyophilized SLNs, indicating good colloidal stability. Drug release was not significantly affected by lyophilization up to 8 h. Drug release percentages at end time were 11.8 ± 0.4, 65.9 ± 0.04, and 31.4 ± 1.95% from fresh AMB-SLNs, PAR-SLNs, and SSZ-SLNs, respectively, and 11.4 ± 0.4, 76.04 ± 0.21, and 31.6 ± 0.33% from lyophilized SLNs, respectively. Thus, rate of release is dependent on API solubility (AMB < SSZ < PAR). Drug release from each matrix followed the Higuchi model and was not affected by lyophilization. The above SLNs show potential for use in delivering hydrophilic and lipophilic drugs. 相似文献
72.
KN Vijayadas HC Davis AS Kotmale RL Gawade VG Puranik PR Rajamohanan GJ Sanjayan 《Chemical communications (Cambridge, England)》2012,48(78):9747-9749
Two folded peptides featuring carboxamide and sulfonamide at the core of the peptide fold have been shown to possess almost similar conformational features, despite the well-known fact that carboxamides and sulfonamides have strikingly different hydrogen-bonding and geometrical preferences. 相似文献
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The effect of a weak magnetic field on the diffusion of noninteracting electrons in a disordered system is studied in a nonlinear-model context. The effective Lagrangian describing the soft modes of the system in the weak field limit is derived. The result does not have the simple form that has been suggested by several authors. Therefore the crossover of the system under a weak perturbing magnetic field is not analogous to that found in spin systems. 相似文献
76.
Hilda Castillo Matthew Yarger Melissa Rappleye Carol Parish 《Journal of Molecular Structure》2004,710(1-3):73-76
The LM:MC conformational search method was used to identify the low energy structures on the OPLS-AA/GBSA(water) and AMBER*/GBSA(water) surfaces for a diastereomeric series of cyclic urea molecules that have been shown to be potent inhibitors of the HIV-1 protease enzyme. The lowest energy structures from each search were then subjected to geometry optimization and frequency analysis using the HF/6-311G** method in conjunction with the self-consistent reaction field (SCRF) treatment for water. A comparison of the diastereomeric energies and structures indicates that the OPLSAA/GBSA(water) surface is in good agreement with the HF/6-311G**/SCRF(water) surface. 相似文献
77.
A system for molybdenum separation and enrichment aiming its determination in water and biological samples by graphite furnace atomic absorption spectrometry (GFAAS) is proposed. The procedure is based on the sorption of the molybdenum (VI) thiocyanate complex onto a mini-column packed with polyurethane foam (PUF). The elution is accomplished by a 3.0 mol l−1 nitric acid solution. Flow variables were optimized and an enrichment factor of 10 as well as a limit of detection (LOD) (3 s) of 0.08 μg l−1 in the sample solution were achieved. The coefficient of variation showed values of 3 and 2% for molybdenum solutions of 2.0 and 10.0 μg l−1, respectively. The accuracy of the method was confirmed by the good concordance between found and certified values in the analysis of certified reference materials (CRMs) (CASS-3 Nearshore Seawater, NIST 1547 Peach Leaves, NIST 1515 Apple Leaves and NIST 1572 Citrus Leaves). The procedure was also applied for the molybdenum determination in mineral waters as well as in produced water samples. The results obtained for the mineral water samples compared well with those obtained by ICP-MS. Concerning the produced water samples, in spite of their large salinity, recoveries of 90 to 120% at the 1 μg l−1 were observed. 相似文献
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Sérgio L. C. Ferreira Marcus L. S. F. Bandeira Valfredo A. Lemos Hilda C. dos Santos A. C. Spinola Costa Djane S. de Jesus 《Fresenius' Journal of Analytical Chemistry》1997,357(8):1174-1178
A simple and very sensitive method has been developed for the determination of ascorbic acid based on the oxidation of ascorbic
acid to dehydroascorbic acid by iron(III), followed by a complexation of iron(II) with 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol(Br-PADAP).
The iron(II) complex is formed immediately, with absorption maxima at 560 and 748 nm and a molar absorptivity of 1.31 × 105 l mole–1cm–1 and 5.69 × 104 l mole–1cm–1, respectively. The ascorbic acid determination is possible with a linear range up to 2.4 μg ml–1, a calibration sensitivity of 0.744 ml μg–1 at 560 nm and 0.323 ml μg–1 at 748 nm, and a detection limit of 15 ng ml–1 and 44 ng ml–1, respectively. The procedure was used for the ascorbic acid determination in several fruit juices and pharmaceutical formulations.
The results demonstrated a good precision (R.S.D. < 1%) and are in agreement with those obtained with others methods. The
Br-PADAP method proposed is six times more sensitive than the method using the iron(II)-1,10-phenanthroline system.
Received: 7 May 1996 / Revised: 1 July 1996 / Accepted: 8 August 1996 相似文献
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