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51.
Sudarma Bogahawaththa Suranga P. Kodithuwakku Kavindra K. Wijesundera Eranga H. Siriweera Lalith Jayasinghe Waruna L. Dissanayaka Jayanthe Rajapakse Chandana B. Herath Tadayuki Tsujita Missaka P. B. Wijayagunawardane 《Molecules (Basel, Switzerland)》2021,26(16)
Chronic liver inflammation has become a major global health concern. In the absence of clinical surrogate markers to diagnose inflammatory liver disease, the intervention with effective drugs in modern medicine tends to be late. In Sri Lanka, traditional medical practitioners prescribe herbal preparations from Osbeckia octandra for the prevention and treatment of liver disorders. To test the efficacy of such treatments, we have administered thioacetamide (TAA) to male Wistar rats to induce chronic liver damage (disease control; DC) and examined how various leaf extracts: crude leaf suspension (CLS), boiled leaf extract (BLE), sonicated leaf extract (SLE), methanol leaf extract (MLE) and hexane leaf extract (HLE) of O. octandra ameliorate TAA-induced liver disease. The CLS, BLE and SLE treatments in cirrhotic rats significantly attenuated disease-related changes, such as liver weight and hepato-enzymes. The mRNA levels of Tnf-α were significantly decreased by 3.6, 10 and 3.9 times in CLS, BLE and SLE compared to DC. The same treatments resulted in significantly lower (19.5, 4.2 and 2.4 times) α-Sma levels compared to DC. In addition, Tgf-β1 and Vegf-R2 mRNA expressions were significantly lower with the treatments. Moreover, BLE expressed a strong anti-angiogenic effect. We conclude that CLS, BLE and SLE from O. octandra have potent hepatic anti-fibrotic effects in TAA-induced liver cirrhosis. 相似文献
52.
A new room-temperature ionic liquid (RTIL) consisting of the fluorinated anion bis(trifluoromethyl)-phosphinate((CF3)2PO2−) coupled with the 1-butyl-3-methyl-imidazoliuim (BMIM) cation has been synthesized and characterized by physicochemical and electrochemical means including differential scanning calorimetry (DSC), thermogravimetric analysis, viscosity, conductivity and cyclic voltammetry measurements. Properties are compared with those of the known RTIL consisting of BMIM coupled with the bis(trifluoromethyl)-sulfonylimide (TFSI) anion. 相似文献
53.
Jose Castro-Perez Thomas P. Roddy Nico M. M. Nibbering Vinit Shah David G. McLaren Stephen Previs Athula B. Attygalle Kithsiri Herath Zhu Chen Sheng-Ping Wang Lyndon Mitnaul Brian K. Hubbard Rob J. Vreeken Douglas G. Johns Thomas Hankemeier 《Journal of the American Society for Mass Spectrometry》2011,22(9):1568-1569
54.
Dr. Hashini N. K. Herath Austin L. MacRae Dr. Angel Ugrinov Prof. Dr. Glenn R. Morello Prof. Dr. Alexander R. Parent 《欧洲无机化学杂志》2023,26(11):e202200747
[Ru(bpyPO3H2)(bpy)Cl]Cl (bpyPO3H2=6,6’-bipyridin-2-yl)phosphonic acid) and [Ru(tpy)(MepyPO3H2)Cl]Cl (MepyPO3H2=(pyridin-2-ylmethyl)phosphonic acid) were synthesized and characterized spectroscopically and electrochemically. Each compound was found to exhibit proton-coupled electron transfer (PCET). In the case of [Ru(bpyPO3H2)(bpy)Cl]Cl, a Ru(V/IV) couple was detected at 1.4 V vs. NHE. Each complex was tested for its ability to catalyze C−H bond oxidation using a variety of sacrificial oxidants, and it was found that under aqueous conditions [Ru(bpyPO3H2)(bpy)Cl]Cl oxidizes secondary C−H bonds using sodium periodate (NaIO4) as the primary oxidant. 相似文献