Solution processable high band gap hosts based on carbazole functionalized cyclic phosphazene cores for application in organic light‐emitting diodes

A new class of solution processable dendrimers based on cyclic phosphazene (CP) cores have been prepared and used as host materials for blue and green organic light emitting diodes (OLEDs). The dendrimers are prepared in high yield from minimal step reactions, are soluble in common solvents for solution processing, are amorphous, and have excellent thermal properties necessary for application in OLEDs. OLED efficiencies of 10.3 cd/A (4.2 lm/W) and 35.3 cd/A (33.5 lm/W) were achieved using commercially available FIrpic and Ir(mppy)₃ as blue and green phosphorescent emitters, respectively. These efficiencies were 2× higher than control devices prepared using poly(N‐vinylcarbazole), the most commonly used host material in solution processed phosphorescent OLEDs. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011     

Fresnel coefficients for a layer of NIM

Reflection and transmission of traveling and evanescent waves by a layer of material with a negative index of refraction (NIM) is studied by means of the Fresnel coefficients. We derive their values in the “NIM limit”, and we show that this limit is consistent with the exact solution. It is also indicated that simply substituting the negative values of the relative permittivity and permeability of the NIM material into the exact solution leads to incorrect results for evanescent waves.     

Building nonredundant adaptive wavelets by update lifting

In this paper, we propose a technique for building adaptive wavelets by means of an extension of the lifting scheme. Our scheme comprises an adaptive update lifting step and a fixed prediction lifting step. The adaptivity consists hereof that the system can choose between two different update filters, and that this choice is triggered by the local gradient of the original signal. If the gradient is large (in some seminorm sense) it chooses one filter, if it is small the other. We derive necessary and sufficient conditions for the invertibility of such an adaptive system for various scenarios. Furthermore, we present some examples to illustrate our theoretical results.     

Coordination mechanisms for inventory control in three-echelon serial and distribution systems

This paper is concerned with the coordination of inventory control in three-echelon serial and distribution systems under decentralized control. All installations in these supply chains track echelon inventories. Under decentralized control the installations will decide upon base stock levels that minimize their own inventory costs. In general these levels do not coincide with the optimal base stock levels in the global optimum of the chain under centralized control. Hence, the total cost under decentralized control is larger than under centralized control. To remove this cost inefficiency, two simple coordination mechanisms are presented: one for serial systems and one for distribution systems. Both mechanisms are initiated by the most downstream installation(s). The upstream installation increases its base stock level while the downstream installation compensates the upstream one for the increase of costs and provides it with a part of its gain from coordination. It is shown that both coordination mechanisms result in the global optimum of the chain being the unique Nash equilibrium of the corresponding strategic game. Furthermore, all installations agree upon the use of these mechanisms because they result in lower costs per installation. The practical implementation of these mechanisms is discussed.     

The apolar bilinear form in geometric modeling

Some recent methods of Computer Aided Geometric Design are related to the apolar bilinear form, an inner product on the space of homogeneous multivariate polynomials of a fixed degree, already known in 19th century invariant theory. Using a generalized version of this inner product, we derive in a straightforward way some of the recent results in CAGD, like Marsden's identity, the expression for the de Boor-Fix functionals, and recursion schemes for the computation of B-patches and their derivatives.

     

A potential approach for ordinal games

We introduce the class of ordinal games with a potential, which are characterized by the absence of weak improvement cycles, the same condition used by Voorneveld and Norde (1997) for ordinal potential games.     

Targeting of cancer cells using click-functionalized polymer capsules

Targeted delivery of drugs to specific cells allows a high therapeutic dose to be delivered to the target site with minimal harmful side effects. Combining targeting molecules with nanoengineered drug carriers, such as polymer capsules, micelles and polymersomes, has significant potential to improve the therapeutic delivery and index of a range of drugs. We present a general approach for functionalization of low-fouling, nanoengineered polymer capsules with antibodies using click chemistry. We demonstrate that antibody (Ab)-functionalized capsules specifically bind to colorectal cancer cells even when the target cells constitute less than 0.1% of the total cell population. This precise targeting offers promise for drug delivery applications.     

Targeted LC–MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA

Based on the template of a recently introduced derivatization reagent for aldehydes, 4-(2-(trimethylammonio)ethoxy)benzeneaminium dibromide (4-APC), a new derivatization agent was designed with additional features for the analysis and screening of biomarkers of lipid peroxidation. The new derivatization reagent, 4-(2-((4-bromophenethyl)dimethylammonio)ethoxy)benzenaminium dibromide (4-APEBA) contains a bromophenethyl group to incorporate an isotopic signature to the derivatives and to add additional fragmentation identifiers, collectively enhancing the abilities for detection and screening of unknown aldehydes. Derivatization can be achieved under mild conditions (pH 5.7, 10 °C). By changing the secondary reagent (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide instead of sodium cyanoborohydride), 4-APEBA is also applicable to the selective derivatization of carboxylic acids. Synthesis of the new label, exploration of the derivatization conditions, characterization of the fragmentation of the aldehyde and carboxylic acid derivatives in MS/MS, and preliminary applications of the labeling strategy for the analysis of aldehydes in urine and plasma are described.     

Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays

One way to profile complex mixtures for receptor affinity is to couple liquid chromatography (LC) on-line to biochemical detection (BCD). A drawback of this hyphenated screening approach is the relatively high consumption of sample, receptor protein and (fluorescently labeled) tracer ligand. Here, we worked toward minimization of sample and reagent consumption, by coupling nano-LC on-line to a light-emitting diode (LED) based capillary confocal fluorescence detection system capable of on-line BCD with low-flow rates. In this fluorescence detection system, a capillary with an extended light path (bubble cell) was used as a detection cell in order to enhance sensitivity. The technology was applied to a fluorescent enhancement bioassay for the acetylcholine binding protein, a structural analog of the extracellular ligand-binding domain of neuronal nicotinic acetylcholine receptors. In the miniaturized setup, the sensitive and low void volume LED-induced confocal fluorescence detection system operated in flow injection analysis mode allowing the measurement of IC₅₀ values, which were comparable with those measured by a conventional plate reader bioassay. The current setup uses 50 nL as injection volume with a carrier flow rate of 400 nL/min. Finally, coupling of the detection system to gradient reversed-phase nano-LC allowed analysis of mixtures in order to identify the bioactive compounds present by injecting 10 nL of each mixture.