Photon kinetics for laser-plasma interactions

A photon kinetic formalism is employed to describe the propagation of short laser pulses in tenuous plasmas. The photon kinetic theory contains all of the ingredients necessary to describe the relativistic nonlinear optics of short laser pulses in plasmas, and the shortest time scale is determined by the local evolution of the index of refraction. We use this feature to implement a photon in cell code, in which the typical time step is much bigger than is the laser field time scale. Additional information provided by the photon kinetic framework is illustrated by one-dimensional (1-D) and two-dimensional (2-D) simulations     

Subcutaneous hydrogel reservoir system for controlled drug delivery

Hydro Med Sciences has developed a subcutaneous reservoir hydrogel implant capable of long term delivery of predetermined doses of various active compounds. The implant is a small-diameter, thin-walled cylindrical capsule containing a therapeutic agent. The hydrogels used for this application were Hydron* type copolymers of 2-hydroxyethyl methacrylate (HEMA). These non-erodible hydrogels are known to be biocompatible, swell reversibly in an aqueous environment, resist biodegradation and do not support microbial growth.     

A gravity-independent single-phase electrode reservoir for capillary electrophoresis applications

Capillary electrophoresis (CE) holds great promise as an in situ analytical technique for a variety of applications. However, typical instrumentation operates with open reservoirs (e.g., vials) to accommodate reagents and samples, which is problematic for automated instruments designed for space or underwater applications that may be operated in various orientations. Microgravity conditions add an additional challenge due to the unpredictable position of the headspace (air layer above the liquid) in any two-phase reservoir. One potential solution for these applications is to use a headspace-free, flow-through reservoir design that is sealed and connected to the necessary reagents and samples. Here, we demonstrate a flow-through high-voltage (HV) reservoir for CE that is compatible with automated in situ exploration needs, and which can be electrically isolated from its source fluidics (in order to prevent unwanted leakage current). We also demonstrate how the overall system can be rationally designed based on the operational parameters for CE to prevent electrolysis products generated at the electrode from entering the capillary and interfering with the CE separation. A reservoir was demonstrated with a 19 mm long, 1.8 mm inner diameter channel connecting the separation capillary and the HV electrode. Tests of these reservoirs integrated into a CE system show reproducible CE system operation with a variety of background electrolytes at voltages up to 25 kV. Rotation of the reservoirs, and the system, showed that their performance was independent of the direction of the gravity vector.