Regio- and Stereoselective Hydroelementation of SF5-Alkynes and Further Functionalizations.

Herein is described a fully regio- and stereoselective hydroelementation reaction of SF₅-alkynes with N, O and S-nucleophiles and further functionalization of the corresponding Z-(hetero)vinyl-SF₅ intermediates, a suitable platform to access α-SF₅ ketones and esters, β-SF₅ amines and alcohols under mild reaction conditions. Experimental and computational comparative studies between SF₅- and CF₃-alkynes have been performed to highlight and explain the difference of reactivity and selectivity observed between these two fluorinated motifs.