1-Phenyl-6,7-disubstituted-aminopropyl)-1,2,3,4-tetrahydroisoquinolines as possible antituberculer agents

The Condensation of 3,4-disubstituted phenylethylamine and benzaldehyde furnished l-phenyl-6,7-disubstituted-1,2,3,4-tetrahydroisoquinolines l. which on reaction with 1,3-dibromopropane gave l-phenyl-6,7-disubstituted-2-(3-bromoprophyl)-1,2,3,4-tetrahydroisoquinolines 2. The reaction of 2 with different secondary amines resulted in the synthesis of 3. The compounds 3 were screened for their in vitro antituberculer activity against Mycobacterium smegmatis, and some of them have been found to be total inhibitors of M. Smegmatis     

Rapid determination of molybdenum in ferromolybdenum and molybdenum additives, with oxine

A rapid method is presented for the gravimetric determination of molybdenum (as the oxinate) in ferromolybdenum and molybdenum additives. The sample is fused with a mixed flux of sodium peroxide and sodium carbonate in a zirconium crucible for complete decomposition. Leaching the cooled fusion cake with water provides instantaneous separation of molybdenum as sodium molybdate from iron(III) and other hydrous oxides. After filtration, the molybdenum is precipitated with oxine after addition of EDTA and oxalate to obviate interference from other metal oxinates, and determined gravimetrically. The precision and accuracy are comparable to those of referee methods.     

ZnO-TiO2 hybrid nanocrystal-loaded,wash durable,multifunction cotton textiles

Life-threatening diseases, especially those caused by pathogens and harmful ultraviolet radiation (UV-R), have triggered increasing demands for comfortable, antimicrobial, and UV-R protective clothing with a long service life. However, developing such textiles with exceptional wash durability is still challenging. Herein, we demonstrate how to fabricate wash durable multifunctional cotton textiles by growing in situ ZnO-TiO₂ hybrid nanocrystals (NCs) on the surface of cellulosic fabrics. The ZnO-TiO₂ hybrid NCs presented high functional efficiency, owing to their high charge transfer/separation. Ultrafine fiber surface pores, utilized as nucleating sites, endowed the uniform growth of NCs and their physical locking. The resulting fabrics presented excellent UV protection factors up to 54, displayed bactericidal efficiency of 100% against Staphylococcus aureus and Escherichia coli, and optimum self-cleaning efficacy. Moreover, the functionalized textiles exhibited robust washing durability, maintaining antibacterial and anti-UV-R efficiency even after 30 extensive washing cycles.

Graphical abstract

     

Self-assembled,wormlike-cylinder network of polystyrene-block-poly(ethylene oxide) micelles in solution

We report the formation of a highly entangled and interconnected, self-assembled, wormlike-cylinder network of polystyrene-block-poly(ethylene oxide) in N, N-dimethylformamide/water. In this system, N,N-dimethylformamide was a common solvent and water was a selective solvent for the poly(ethylene oxide) blocks. The degrees of polymerization of the polystyrene and poly(ethylene oxide) blocks were 962 and 227, respectively. The network was formed at copolymer concentrations higher than 0.4 wt % and consisted of self-assembled, wormlike cylinders that were interconnected by Y-shaped, T-shaped, and multiple junctions. The network morphology was visualized with transmission electron microscopy. Capillary viscometry measurements revealed an order-of-magnitude increase in the inherent viscosity of the colloidal system upon the formation of the network. A similar effort to obtain a wormlike-cylinder network in an N,N-dimethylformamide/acetonitrile system, in which acetonitrile was a selective solvent for the poly(ethylene oxide) blocks, was unsuccessful even at high copolymer concentrations; instead, the wormlike cylinders showed a tendency to align. The viscosity measurements also did not show a substantial increase in the inherent viscosity. Thus, the solvent played a critical role in determining the formation of the self-assembled, wormlike-cylinder network. This formation of the network resulted from an interplay between the end-capping energy, bending energy (curvature), and configurational entropy of the self-assembled, wormlike-cylinder micelles that minimized the free energy. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 3605–3611, 2006     

Zirconium(IV) Thorium(IV) and Dioxouranium(VI) Complexes of Salicylidene o-Aminobenzothiol

Salicylidene-o-aminobenzothiol and its 5-chloro and 5-bromo derivatives, dibasic tridentate Schiff bases, dervied from the condensation of o-aminothiol and Salicylaldehyde, 5-chloro salicylaldehyde and 5-bromo salicylaldehyde, were used for coordination with Zr(IV), Th(IV) and UO₂(VI) metal inos. The I:I (metal-ligand) stoichiometry of these complexes is shown by elemental analysis and conductometric titrations. Molecular structure of these complexes are proved by Infra-red spectroscopy and thermogravimetric analysis. Magnetic susceptibility measurements of Zr(IV), Th(IV) and UO₂(VI) complexes show their diamagnetic and octahedral geometry. Results show that all the complexes have solvent molecules in coordination with metal ion.     

Rapid spectrophotonietric determination of copper in steel with zinc dibenzyldithiocarbamate

A rapid spectrophotometric method employing zinc dibenzyldithiocarbamate is described for determining copper in a wide variety of steels. The acidity is not critical (0.5-2N) and the colour of the complex is stable for > 1 hr. The range of the method is 0.005-5% copper and 6 samples can be analysed in about an hour.     

Synthesis and stereochemical assignment of 7-arylidene and 7-heteroarylidene morphinan-6-ones

A number of (E)-7-arylidenenaltrexones were synthesized by azeotropic distillation of water from a benzene solution of naltrexone and an aromatic aldehyde (benzaldehyde, 4-chloro- and 4-fluorobenzaldehyde, 3-and 4-pyridinecarboxaldehyde and 1-methyl-2-imidazolecarboxaldehyde) using piperidine as a catalyst. In addition, (E)-7-benzylidenenaloxone was prepared by the previously published Claisen-Schmidt condensation using sodium hydroxide in methanol. The stereochemistry of these arylidene derivatives 3–9 was determined to be (E) by means of nuclear Overhauser enhancement experiments. The ¹³C nmr spectra of (E)- 3–9 are recorded in deuteriochloroform and those of the hydrochlorides in deuteriodimethyl sulfoxide.     

Studies in inorganic polyelectrolytes — Part II

Viscosity behaviour of several samples ofGraham's salt with varying molecular weight has been studied. Reduced viscosity (η _sp /c) versus concentration curves were found to be characteristic of polyelectrolytes. They are dependent on the molecular weight and can be reduced to straight lines by plotting the reciprocal of the reduced viscosity against the square root of concentration. The intrinsic viscosities obtained by extrapolation were found to be proportional to the square of molecular weights. The value of reduced viscosity at any particular concentration in the concentration range between 0.25% and 4.0% was linearly related to the molecular weight. Reduced viscosities were found to decrease considerably on addition of electrolytes. Reduced viscosity versus added salt concentration curves were remarkably molecular weight dependent. The p_H of the medium seemed to have no effect at all. Bivalent salts reduce the viscosity to a much greater extent than monovalent ones. By keeping the concentration of the added salt constant and varying that ofGraham's salt, curves showing hump which disappeared at higher concentration of the added salt, were obtained. In the action of electrolytes the more important factor is the valency of cation rather than the ionic strength of the medium. Most observations confirm the already well-establishedFolding-Chain Theory of polyelectrolytes developed byKatchalsky, Fuoss and others.     

Increased porous morphology and thermal degradation of electron beam-irradiated PVDF-HFP/LiCLO4 polymer electrolyte

The effect of 8?MeV energy electron beam radiation at 40, 80 and 120?kGy dosage on surface morphology and thermal properties of lithium perchlorate-doped poly (vinylidene fluoride-co-hexafluoropropylene) polymer electrolyte films have been studied. The field emission scanning electron microscopic image shows small-porous structured morphology for unirradiated film, but it changed drastically into large and deep porous structure as well as the size of spherulites is reduced for 120?kGy confirming the influence of irradiation on morphology. The atomic force microscope reveals the significantly changed surface roughness of unirradiated film from 116.8 to 123.4?nm with a hill-like pattern morphology for 120?kGy confirming the increased amorphousity after irradiation. The thermal study confirmed that the decrease in the melting point of unirradiated film 160.86–155.24°C for 120?kGy doses is attributed to the formation of defects by the chain scissioning process resulting in the degradation of polymer electrolytes at high dose.