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361.
Discriminating by color : A 2D colorimetric indicator array has been designed by a crystal engineering approach (N???H? O hydrogen bonding and charge‐transfer complexation) involving solid‐state co‐grinding for the visual discrimination of positional isomers of dihydroxynaphthalene. Factors governing the close packing of π planes, and hence color of the complex, were determined by single‐crystal X‐ray analysis, allowing fine tuning by crystal engineering.
362.
Rabin Neupane Saloni Malla Mariam Sami Abou-Dahech Swapnaa Balaji Shikha Kumari Digambar Kumar Waiker N. S. Hari Narayana Moorthy Piyush Trivedi Charles R. Ashby Jr. Chandrabose Karthikeyan Amit K. Tiwari 《Molecules (Basel, Switzerland)》2021,26(15)
A novel series of 4-anilinoquinazoline analogues, DW (1–10), were evaluated for anticancer efficacy in human breast cancer (BT-20) and human colorectal cancer (CRC) cell lines (HCT116, HT29, and SW620). The compound, DW-8, had the highest anticancer efficacy and selectivity in the colorectal cancer cell lines, HCT116, HT29, and SW620, with IC50 values of 8.50 ± 2.53 µM, 5.80 ± 0.92 µM, and 6.15 ± 0.37 µM, respectively, compared to the non-cancerous colon cell line, CRL1459, with an IC50 of 14.05 ± 0.37 µM. The selectivity index of DW-8 was >2-fold in colon cancer cells incubated with vehicle. We further determined the mechanisms of cell death induced by DW-8 in SW620 CRC cancer cells. DW-8 (10 and 30 µM) induced apoptosis by (1) producing cell cycle arrest at the G2 phase; (2) activating the intrinsic apoptotic pathway, as indicated by the activation of caspase-9 and the executioner caspases-3 and 7; (3) nuclear fragmentation and (4) increasing the levels of reactive oxygen species (ROS). Overall, our results suggest that DW-8 may represent a suitable lead for developing novel compounds to treat CRC. 相似文献
363.
Gupta RK Trivedi R Awasthi R Paliwal VK Prasad KN Rathore RK 《Magnetic resonance imaging》2012,30(1):104-111
Diffusion tensor imaging (DTI) was performed on 25 patients with neurocysticercosis (NCC). The aim of this study was to investigate the changes in DTI measures during the evolutionary course of NCC lesions from vesicular to calcified stage in the brain. DTI measures were quantified from the NCC lesions of all patients. On the basis of conventional imaging findings, NCC lesions were classified into vesicular, vesicular colloidal, granular nodular and calcified stages. Significant inverse correlation was observed between the evolutionary stage of NCC lesion and mean diffusivity (MD; r=−0.748, P<0.001) and spherical anisotropy (CS; r=−0.585, P<.001) values. Significant direct correlations were observed between evolutionary stages of NCC lesion and mean fractional anisotropy (FA; r=0.575, P<0.001), linear anisotropy (CL; r=0.478, p<0.001) and planar anisotropy (CP; r=0.561, p<0.001) values. Successive decrease in MD values calculated from NCC lesions was observed, moving from vesicular to granular nodular stage. On FA, CL and CP maps, a significant increase in signal intensity value was observed in calcified as compared to other stages. We conclude that DTI measures may indicate the evolutionary changes in NCC from vesicular to calcified stage. 相似文献
364.
Larry D. Bratton Paul C. Unangst J. Ronald Rubin Bharat K. Trivedi 《Journal of heterocyclic chemistry》2001,38(5):1103-1111
The preparation of a variety of derivatives of 2‐oxa‐1,3,4,10‐tetraazacyclopenta[b]fluoren‐9‐one 1 is described. A series of substituted indan‐1‐ones were prepared and oxidized with N‐bromosuccinimide and dimethyl sulfoxide to the corresponding ninhydrin derivatives. Cyclization of the ninhydrins with furazan‐3,4‐diamine yielded the target tetracycles. Appropiate choice of substituents in ninhydrins led to a preference for one regioisomer in the target tetracycles. This permitted the synthesis of a variety of 8‐substituted hetero‐cycles. In those instances where isomer formation was possible, structural assignments were confirmed by X‐ray crystallography. 相似文献
365.
Larry D. Bratton Bruce D. Roth Bharat K. Trivedi Paul C. Unangst 《Journal of heterocyclic chemistry》2000,37(5):1103-1108
The preparation of several novel 3,5‐substituted‐indole‐2‐carboxamides is described. A 5‐nitro‐indole‐2‐carboxylate was elaborated to the 3‐benzhydryl ester, N‐substituted ester, and carboxylic acid intermedi ates, followed by conversion to the amide and then reduction of the 5‐nitro group to the amine. Indole‐2‐carboxamides with 3‐benzyl and 3‐phenyl substituents were prepared in four steps from either a 3‐bromo indole ester using the Suzuki reaction or from a 3‐keto substituted indole ester. N‐Alkylation of ethyl indole‐2‐carboxylate, followed by amidation and catalytic addition of 9‐hydroxyxanthene gave a 3‐xanthyl‐indole‐2‐carboxamide analog and a spiropyrrolo indole as a side product. 相似文献
366.
We report a generalization of our earlier formalism [Pramana, 54, 663 (1998)] to obtain exact solutions of Einstein-Maxwell’s equations for static spheres filled with a charged fluid having
anisotropic pressure and of null conductivity. Defining new variables: w=(4π/3)(ρ+ε)r
2, u=4πξr
2, v
r=4πp
r
r
2, v
⊥=4πp
⊥
r
2[ρ, ξ(=−(1/2)F
14
F
14), p
r, p
⊥ being respectively the energy densities of matter and electrostatic fields, radial and transverse fluid pressures whereas
ε denotes the eigenvalue of the conformal Weyl tensor and interpreted as the energy density of the free gravitational field],
we have recast Einstein’s field equations into a form easy to integrate. Since the system is underdetermined we make the following
assumptions to solve the field equations (i) u=v
r=(a
2/2κ)r
n+2, v
⊥=k
1
v
r, w=k
2
v
r; a
2, n(>0), k
1, k
2 being constants with κ=((k
1+2)/3+k
2) and (ii) w+u=(b
2/2)r
n+2, u=v
r, v
⊥−v
r=k, with b and k as constants. In both cases the field equations are integrated completely. The first solution is regular in the metric as
well as physical variables for all values of n>0. Even though the second solution contains terms like k/r
2 since Q(0)=0 it is argued that the pressure anisotropy, caused by the electric flux near the centre, can be made to vanish reducing
it to the generalized Cooperstock-de la Cruz solution given in [14]. The interior solutions are shown to match with the exterior
Reissner-Nordstrom solution over a fixed boundary.
Dedicated to Prof. F A E Pirani. 相似文献
367.
368.
369.