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排序方式: 共有160条查询结果,搜索用时 18 毫秒
101.
Aequationes mathematicae - We consider the differentiability of the solution $${F:I\times }{{\mathbb {R}}}\rightarrow I$$ of the translation equation, where I is an interval. The stability of this... 相似文献
102.
103.
Meshkat S Klon AE Zou J Wiseman JS Konteatis Z 《Journal of chemical information and modeling》2011,51(1):52-60
We introduce TICRA (transplant-insert-constrain-relax-assemble), a method for modeling the structure of unknown protein-ligand complexes using the X-ray crystal structures of homologous proteins and ligands with known activity. We present results from modeling the structures of protein kinase-inhibitor complexes using p38 and Lck as examples. These examples show that the TICRA method may be used prospectively to create and refine models for protein kinase-inhibitor complexes with an overall backbone rmsd of less than 0.75 ? for the kinase domain, when compared to published X-ray crystal structures. Further refinement of the models of the kinase domains of p38 and Lck in complex with their cognate ligands from the published crystal structures was able to improve the rmsd's of the model complexes to below 0.5 ?. Our results show that TICRA is a useful approach to the problem of structure-based drug design in cases where little structural information is available for the target proteins and the binding mode of active compounds is unknown. 相似文献
104.
Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages. 相似文献
105.
In this paper we investigate the following two questions:
相似文献
106.
Elzbieta Jastrzebska Sylwia Flis Aleksandra Rakowska Michal Chudy Zenon Jastrzebski Artur Dybko Zbigniew Brzozka 《Mikrochimica acta》2013,180(9-10):895-901
We have investigated the response of normal and cancer cells to exposure a combination of celecoxib (Celbx) and 5-fluorouracil (5-FU) using a lab-on-a-chip microfluidic device. Specifically, we have tested the cytotoxic effect of Celbx on normal mouse embryo cells (Balb/c 3T3) and human lung carcinoma cells (A549). The single drugs or their combinations were adjusted to five different concentrations using a concentration gradient generator (CGG) in a single step. The results suggest that Celbx can enhanced the anticancer activity of 5-FU by stronger inhibition of cancer cell growth. We also show that the A549 cancer cells are more sensitive to Celbx than the Balb/c 3T3 normal cells. The results obtained with the microfluidic system were compared to those obtained with a macroscale in vitro cell culture method. In our opinion, the microfluidic system represents a unique approach for an evaluation of cellular response to multidrug exposure that also is more simple than respective microwell plate assays. Figure
? 相似文献
107.
Aneta M. Tomkiel Krzysztof Brzezinski Zenon Łotowski Leszek Siergiejczyk Piotr Wałejko Stanisław Witkowski Jan Kowalski Jolanta Płoszyńska Andrzej Sobkowiak Jacek W. Morzycki 《Tetrahedron》2013
A new protocol for the electrochemical synthesis of glycoconjugates is presented. Thioether derivatives of cholesterol and other sterols were subjected to anodic oxidation in the presence of a sugar alcohol affording glycoconjugates with the sugar linked to a steroid moiety by an ether bond. The isomeric 6β-3α,5α-cyclo-steroidal thioethers proved to be better sterol donors than the normal 3β-Δ5-steroidal thioethers. 相似文献
108.
Zenon Moszner 《Aequationes Mathematicae》2009,77(1-2):33-88
109.
110.
Zenon Rychter 《Zeitschrift für Angewandte Mathematik und Physik (ZAMP)》1986,37(6):919-923
Summary The report shows that Nordgren's [3] bound on the error of solutions in Reissner's theory of anisotropic plates can be improved in the case of plates with large transverse shear deformability.
Zusammenfassung Diese Mitteilung beweist, daß Nordgren's [3] Fehlerabschätzung für Lösungen der Reissnerschen Theorie der anisotropen Platten für Platten mit schwacher Schiebungssteifigkeit der Querschnitte verbessert werden kann.相似文献