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91.
Ito M Ogino H Oshima H Shiraki N Shibamoto Y Kasai H Mase M Kawamura Y Miyati T 《Magnetic resonance imaging》2006,24(5):625-630
PURPOSE: A newly developed contrast material, CH3-DTPA-Gd (NMS60), a trimer containing 3 Gd(3+) atoms per molecule, has been shown to offer greater enhancement and longer vascular retention than gadopentetate dimeglumine (Gd-DTPA) in animals. We report on our early phase II study on NMS60 in brain tumor patients together with supplementary investigations. METHODS AND MATERIALS: The longitudinal relaxation rate (R(1)=1/T(1)) and the transverse relaxation rate (R(2)*=1/T(2)*) of NMS60 and Gd-DTPA were determined at 20 degrees C in water at 1.5 T. An NMS60 dose of 0.1 or 0.2 mmol (Gd)/kg was randomly assigned and administered to 10 patients (five women, five men; mean age: 49 years) with brain tumors. Safety and contrast-enhancing ability of NMS60 were evaluated. Dual dynamic contrast-enhanced T(1) and R(2)* studies (DUCE imaging) were also carried out in two patients. RESULTS: Regarding the relaxivity per Gd, R(1) and R(2)* of NMS60 were 9.5 and 11.0 (mmol/L x s)(-1), respectively, compared to 4.8 and 7.2 (mmol/L x s)(-1) for Gd-DTPA. Although a transient slight increase of alanine aminotransferase was observed in one case, no other adverse reactions were observed after administration of NMS60. Contrast enhancement by NMS60 was excellent at both concentrations, and when tumor detectability was assessed with a five-point scale, the diagnostic usefulness was 4 or higher in all cases. In DUCE imaging, NMS60 appeared to show high signal intensity, when compared with the data obtained separately for Gd-DTPA. CONCLUSION: NMS60 had a high contrasting effect and little toxicity, and is expected to be clinically useful. 相似文献
92.
Yuta Hashimoto 《Journal of solid state chemistry》2003,176(1):266-272
Magnetic properties of ternary sodium oxides NaLnO2 (Ln=rare earths) are investigated. Their crystal structures are grouped into three types of structures, which are α-LiFeO2, β-LiFeO2, and α-NaFeO2, depending on the size of rare earths. Their magnetic susceptibilities and specific heats have been measured from 1.8 to 300 K. Among them, NaGdO2, NaDyO2, and NaHoO2 show antiferromagnetic transitions at 2.4, 2.2, and 2.4 K, respectively, and NaNdO2 transforms to the ferromagnetic state below 2.4 K. NaSmO2, NaErO2, and NaYbO2 exhibit a magnetic anomaly below 1.8 K. 相似文献
93.
Takimiya K Kunugi Y Toyoshima Y Otsubo T 《Journal of the American Chemical Society》2005,127(10):3605-3612
A series of 2,6-diaryl-substituted naphtho[1,8-bc:5,4-b'c']dithiophene derivatives 2-6, whose aryl groups include 5-hexyl-2-thienyl, 2,2'-bithiophen-5-yl, phenyl, 2-naphthyl, and 4-biphenylyl, was synthesized by the palladium-catalyzed Suzuki-Miyaura coupling and utilized as active layers of organic field-effect transistors (OFETs). All devices fabricated using vapor-deposited thin films of these compounds showed typical p-type FET characteristics. The mobilities are relatively good and widely range from 10(-4) to 10(-1) cm2 V(-1) s(-1), depending on the substituent groups. Among them, the mobilities of the devices using films of 3-5 tend to increase with the increasing temperature of the Si/SiO2 substrate during film deposition. In particular, the device based on the naphthyl derivative 5, when fabricated at 140 degrees C, marked a high mobility of 0.11 cm2 V(-1) s(-1) with an on/off ratio of 10(5), which is a top class of performance among organic thin-film transistors. Studies of X-ray diffractograms (XRDs) have revealed that the film of 4 and 5 is composed of two kinds of crystal grains with different phases, so-called "single-crystal phase" and "thin film phase", and that the proportion of the thin film phase increases with an increase of the substrate temperature. In the thin film phase the assembled molecules stand nearly upright on the substrate in such a way as to be favorable to carrier migration. 相似文献
94.
The mass distributions obtained from a K?p experiment at 5.5 GeV/c are used to study the recent suggestion of an s-wave Kπ resonance at 1360 MeV. Using a model including s- and p- wave and , s-, p- and d-wave amplitudes, we analyze the spherical harmonic moments 〈Yl0〉 of the Kπ decay angular distribution in the K1 (1420) mass region and obtain the result that the reported mass of 1360 MeV does not necessarily represent the resonance position and is influenced by cuts made in the Kπ decay angle. 相似文献
95.
Kirihara M Okubo K Uchiyama T Kato Y Ochiai Y Matsushita S Hatano A Kanamori K 《Chemical & pharmaceutical bulletin》2004,52(5):625-627
Thiols were converted into disulfide by the aerobic oxidation catalyzed by trichlorooxyvanadium in the presence of molecular sieves 3A. 相似文献
96.
Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (−)‐Lyngbyaloside B
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Prof. Dr. Haruhiko Fuwa Naoya Yamagata Yuta Okuaki Yuya Ogata Asami Saito Prof. Dr. Makoto Sasaki 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(20):6815-6829
We have described in detail the total synthesis of both the proposed and correct structures of (?)‐lyngbyaloside B, which facilitated the elucidation of the complete stereostructure of this natural product. Our study began with the total synthesis of 13‐demethyllyngbyaloside B, in which an esterification/ring‐closing metathesis (RCM) strategy was successfully used for the efficient construction of the macrocycle. We also established reliable methods for the introduction of the conjugated diene side chain and the l ‐rhamnose residue onto the macrocyclic framework. However, the esterification/RCM strategy proved ineffective for the parent natural product because of the difficulties in acylating the sterically encumbered C‐13 tertiary alcohol; macrolactionization of a seco‐acid was also extensively investigated under various conditions without success. We finally completed the total synthesis of the proposed structure of (?)‐lyngbyaloside B by means of a macrolactonization that involves an acyl ketene as the reactive species. However, the NMR spectroscopic data of our synthetic material did not match those of the authentic material, which indicated that the proposed structure must be re‐examined. Inspection of the NMR spectroscopic data of the natural product and molecular mechanics calculations led us to postulate that the configuration of the C‐10, C‐11, and C‐13 stereogenic centers had been incorrectly assigned in the proposed structure. Finally, our revised structure of (?)‐lyngbyaloside B was unambiguously verified through total synthesis. 相似文献
97.
Yuta Ito Dr. Masafumi Ueda Dr. Norihiko Takeda Prof. Dr. Okiko Miyata 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(8):2616-2619
A novel reductive Fischer indolization of readily available N‐aryl conjugated hydrazones with tert‐butyl iodide has been developed. In this reaction, tert‐butyl iodide is used as anhydrous HI source, and the generated HI acts as a Brønsted acid and a reducing agent. This operationally simple method allows access to various indole derivatives. Furthermore, the procedure can be applied to the synthesis of biologically active compounds. 相似文献
98.
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100.
Yuta Saga Yuka Mino Shin-ichi Kawaguchi Daoqing Han Akiya Ogawa Li-Biao Han 《Tetrahedron: Asymmetry》2017,28(1):84-89
A variety of P-stereogenic organophosphorus compounds can be readily prepared by stereoretentive addition. The PMe3-catalyzed addition of optically active (?)MenthylO(Ph)P(O)H compounds to electron deficient alkenes occur stereospecifically, to produce the corresponding P-stereogenic adducts in high yields. By simply removing the volatiles under vacuum, spectroscopically pure products can be obtained. The present method provides a salt-free clean process for the preparation of P-chiral organophosphorus compounds. 相似文献