全文获取类型
收费全文 | 449篇 |
免费 | 10篇 |
专业分类
化学 | 385篇 |
晶体学 | 2篇 |
力学 | 4篇 |
数学 | 30篇 |
物理学 | 38篇 |
出版年
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 13篇 |
2020年 | 7篇 |
2019年 | 9篇 |
2018年 | 8篇 |
2017年 | 10篇 |
2016年 | 14篇 |
2015年 | 10篇 |
2014年 | 13篇 |
2013年 | 19篇 |
2012年 | 23篇 |
2011年 | 27篇 |
2010年 | 16篇 |
2009年 | 12篇 |
2008年 | 28篇 |
2007年 | 22篇 |
2006年 | 31篇 |
2005年 | 20篇 |
2004年 | 27篇 |
2003年 | 19篇 |
2002年 | 14篇 |
2001年 | 11篇 |
2000年 | 4篇 |
1999年 | 7篇 |
1998年 | 5篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1992年 | 3篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 8篇 |
1978年 | 2篇 |
1977年 | 4篇 |
1975年 | 3篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1968年 | 1篇 |
1962年 | 1篇 |
1961年 | 2篇 |
1958年 | 1篇 |
排序方式: 共有459条查询结果,搜索用时 15 毫秒
111.
We perform a molecular dynamics simulation for CO2 + ketone mixtures to study the molecular motility and elucidate how CO2 molecules are dissolved in a mixture. The self-diffusion coefficients increase with increasing CO2 mole fraction (xCO2) and decreased with increasing molecular weight. These results mean that the mobility of molecules depends on the molecular size. To study molecular aggregation around CO2 molecules, radial distribution functions (RDFs) and the distance from neighboring molecules to CO2 molecules were calculated. The RDFs indicate that the CO2 molecule exists near the carbonyl oxygen atom. Because of the distance of the neighboring molecule from the CO2 molecule, the CO2 molecule is less likely to exist around a branched alkyl ketone than a normal alkyl ketone. 相似文献
112.
Ashraf Ghanem Mohammed Nabil Aboul-Enein Aida El-Azzouny Mohammed F. El-Behairy 《Journal of chromatography. A》2010,1217(7):1063-1074
The enantioselective resolution of a set of racemic acidic compounds such as non-steroidal anti-inflammatory drugs (NSAIDs) of the group arylpropionic acid derivatives is demonstrated. Thus, a set of lipases were screened and manipulated in either the esterification or hydrolysis mode for the enantioselective kinetic resolution of these racemates in non-standard organic solvents. The accurate determination of the enantiomeric excesses of both substrate and product during such reaction is demonstrated. This was based on the development of a direct and reliable enantioselective high performance liquid chromatography (HPLC) procedure for the simultaneous baseline separation of both substrate and product in one run without derivatization. This was achieved using the immobilized chiral stationary phase namely Chiralpak IB, a 3,5-dimethylphenylcarbamate derivative of cellulose (the immobilized version of Chiralcel OD) which proved to be versatile for the monitoring of the lipase-catalyzed kinetic resolution of racemates in non-standard organic solvents. 相似文献
113.
The in vitro reactivities of astaxanthin and β-carotene toward peroxynitrite were investigated and the reaction products after scavenging with peroxynitrite were analyzed. A series of carotenoids substituted with nitro group, 14′-s-cis-15′-nitroastaxanthin, 10′-s-cis-11′-cis-11′-nitroastaxanthin, 14′-s-cis-15′-nitro-β-carotene and 10′-s-cis-11′-cis-11′-nitro-β-carotene, were isolated from the reaction products of carotenoids with peroxynitrite. Carotenoids with nitro derivatives were reported for the first time. These results indicated that astaxanthin and β-carotene could catch peroxynitrite or nitrogen dioxide radical (NO2) in their molecule to form nitrocarotenoids. 相似文献
114.
Akai N Harada T Shin-Ya K Ohno K Aida M 《The journal of physical chemistry. A》2006,110(18):6016-6022
The photoreaction of 2-amino-5-methylpyridine was investigated by matrix-isolation infrared spectroscopy and DFT calculation. Photoinduced reversible amino (N=C-NH(2))-imino (NH-C=NH) tautomerism was found between 2-amino-5-methylpyridine and 5-methyl-2(1H)-pyridinimine; the amino tautomer changes to the imino tautomer by UV irradiation (340>lambda>or= 300 nm) and the reverse change occurs by longer-wavelength light irradiation (420>lambda>or= 340 nm). The results of the CASSCF calculation revealed that the amino-imino tautomerism proceeds in vibrational relaxation process from electronic excited state to the ground state. The IR spectra of 2-amino-5-methylpyridine in the T(1) state and 5-methyl-2-pyridinamino radical were also obtained by UV irradiation (lambda>or= 300 nm). 相似文献
115.
Motoyanagi J Fukushima T Ishii N Aida T 《Journal of the American Chemical Society》2006,128(13):4220-4221
A coumarin-appended amphiphilic hexa-peri-hexabenzocoronene (1) self-assembled to form graphitic nanotubes. Upon irradiation of lambda > 300 nm, the nanotubes in the solid state and suspension both underwent dimerization of the coumarin pendants, affording covalently stitched nanotubes, which were hardly soluble in CHCl3, a good solvent of 1. In contrast, a thin film cast from a homogeneous solution of 1 was intact to photoirradiation. Owing to the reversible nature of the photochemical stitching, both negative and positive patterns of the graphitic nanotubes were developed on a silicon substrate by a lithographic post processing. 相似文献
116.
Li WS Kim KS Jiang DL Tanaka H Kawai T Kwon JH Kim D Aida T 《Journal of the American Chemical Society》2006,128(32):10527-10532
Dendritic molecules appended with multiple zinc porphyrin units (DPm, m [number of zinc porphyrin units] = 6, 12, and 24) trap bipyridine compounds carrying multiple fullerene units (Py2Fn, n [number of C60 units] = 1-3), affording coordination complexes DPm superset Py2Fn having a photoactive layer consisting of spatially segregated donor and acceptor arrays on their surface. Complexes DPm superset Py2Fn are stable enough (K [average binding affinity] = 1.1 x 10(6)-4.4 x 10(6) M(-1) in CHCl3 at 25 degrees C) to be isolated by gel permeation chromatography. UHV-STM microscopy enables clear visualization of a petal-like structure of DP12 superset Py2F3. Photoexcitation of the zinc porphyrin units in DPm superset Py2Fn results in a zinc porphyrin-to-fullerene electron transfer to generate a charge separation. The charge-separation rate constant (kCS) in CH2Cl2 at 20 degrees C increases from 0.26 x 10(10) to 2.3 x 10(10) s(-1) upon increment of m and n, whereas the charge-recombination rate constant (kCR) remains almost unchanged at 4.5 x 10(6)-6.7 x 10(6) s(-1). Consequently, DP24 supersetPy2F3 furnishes the largest ratio of kCS/kCR (3400) among the family. 相似文献
117.
Cytidine deaminase is known as an important enzyme responsible for the hydrolytic deamination of cytidine, which is applied as a key step to the conversion of the precursor of the cancer drug to an active form in the living body. Cytidine with water is efficiently converted to uridine with ammonia in the cleft of cytidine deaminase. In this work, the catalysis of cytidine deaminase for the hydrolytic deamination was examined using cytosine as a model of cytidine and the model molecules for the active site of cytidine deaminase by means of the quantum chemical method. We especially investigated the contribution of the water molecule from the solvent to the catalysis, because the X-ray diffraction analysis of a crystal structure has revealed the existence of the water molecule in the vicinity of the substrate bound to the active site inside the cleft. Our computations showed that the extra water molecule from the solvent has a possibility to support the catalysis of cytidine deaminase. 相似文献
118.
Wei‐Shi Li Prof. Dr. Akinori Saeki Dr. Yohei Yamamoto Dr. Takanori Fukushima Dr. Shu Seki Prof. Dr. Noriyuki Ishii Dr. Kenichi Kato Dr. Masaki Takata Prof. Dr. Takuzo Aida Prof. Dr. 《化学:亚洲杂志》2010,5(7):1566-1572
To tailor organic p/n heterojunctions with molecular‐level precision, a rational design strategy using side‐chain incompatibility of a covalently connected donor–acceptor (D–A) dyad has been successfully carried out. An oligothiophene–perylenediimide dyad, when modified with triethylene glycol side chains at one terminus and dodecyl side chains at the other ( 2 Amphi ), self‐assembles into nanofibers with a long‐range D/A heterojunction. In contrast, when the dyad is modified with dodecyl side chains at both termini ( 2 Lipo ), ill‐defined microfibers result. In steady‐state measurements using microgap electrodes, a cast film of the nanofiber of 2 Amphi displays far better photoconducting properties than that of the microfiber of 2 Lipo . Flash‐photolysis time‐resolved microwave conductivity measurements, in conjunction with transient absorption spectroscopy, clearly indicate that the nanofiber of 2 Amphi intrinsically allows for better carrier generation and transport properties than the microfibrous assembly of 2 Lipo . 相似文献
119.
The tautomerism and dimerization of 4(3H)-pyrimidinone (4(3H)Pyr) in carbon tetrachloride (CCl4) and chloroform (CHCl3) solutions were investigated using IR spectroscopy and quantum chemical calculations. The observed IR spectra in the NH and OH stretching regions clearly revealed the predominance of the keto tautomer in both solvent systems. The enol form only exists in a very small proportion in the CCl4 solution. The tautomeric constant for the two monomers KT[OH/NH] = 0.012 and DeltaE = 2.62 kcal/mol were estimated at 25 degrees C. This result was supported by the self-consistent reaction field/polarizable continuum (SCRF/PCM) calculation at the MP4(full, SDQ)/aug-cc-pVDZ level, which predicted DeltaE = 3.06 kcal/mol in CCl4. In the C=O stretching region, two bands were observed, suggesting the coexistence of two keto structures at equilibrium. The calculated IR spectra indicated that the bands at 1711 and 1675 cm(-1) arise from the keto monomer and keto-keto (KK) ring dimer, respectively. At elevated temperature, the populations of both the keto and enol monomers increased for the CCl4 solution. The present study revealed that the keto <--> enol tautomerization does not occur in the isolated monomer molecule. The double proton transfer (DPT) reaction in the KK ring dimer presumably plays a substantial role in the population increase of the enol monomer. To our knowledge, this may be the first observation of the tautomerization in a model base pair via the temperature-induced ground-state DPT reaction under a nonpolar liquid environment reported so far. This tautomerism can serve as a mimic circumstance for the spontaneous mutations induced by proton transfer in the DNA base pairs. 相似文献