A metabolomics strategy for authentication of plant medicines with multiple botanical origins,a case study of Uncariae Rammulus Cum Uncis

Source authentication of herbal medicines was essential for ensuring their safety, efficacy and quality consistency, especially those with multiple botanical origins. This study proposed a metabolomics strategy for species discrimination and source recognition. Uncariae Rammulus Cum Uncis, officially stipulating the stems with hooks of five Uncaria species as its origins, was taken as a case study. Firstly, an untargeted MS^E method was developed by ultra‐high performance liquid chromatography hyphenated with quadrupole time‐of‐flight mass spectrometry for global metabolite characterization. Subsequently, data pretreatment was conducted by using Progenesis QI software and screening rules. The obtained metabolite features were defined as variables for statistical analyses. Principal component analysis and chemical fingerprinting spectra suggested that five official species were differentiated from each other except for Uncaria hirsuta and Uncaria sinensis. Furthermore, orthogonal partial least squares discrimination analysis was performed to discriminate confused two species, and resulted in the discovery of nine contributing markers. Ultimately, a Support Vector Machine model was developed to recognize five species and predict origins of commercial materials. The study demonstrated that the developed strategy was effective in discrimination and recognition of confused species, and promising in tracking botanical origins of commercial materials.     

Multistable polymer stabilised cholesteric liquid crystal: exceeding reflection limit in visible region

Cholesteric liquid crystal (CLC) with helically aligned molecules, demonstrates unique optical features. Conventionally, such structure reflects a maximum 50% of unpolarised light. Polymer-stabilised CLC was designed to exceed the limit by mixing liquid crystal (LC) and a photopolymerisable monomer of opposite chirality. The reflectance was carefully investigated and the result was 55.7% in the visible region at room temperature, where it exceeded the theoretical limit. Such phenomena were studied and theoretical model was discussed. Electro-optical test showed the driving voltage was of LC cell was slightly changed after polymerisation.     

利用Paal-Knorr反应在无催化剂和溶剂条件下合成吡咯衍生物

Paal-Knorr合成法是一个常见的吡咯合成方法。本文报道了无需使用任何催化剂和溶剂,在室温条件下多种胺(包括脂肪胺、芳香胺)和2,5-己二酮发生Paal-Knorr缩合反应,且合成的吡咯衍生物产率较高。这种合成方法具有反应条件温和、实验操作步骤简单以及产物容易分离等优点,具有一定的实用价值。     

Determination of sudan dyes in red wine and fruit juice using ionic liquid-based liquid-liquid microextraction and high-performance liquid chromatography

The liquid-liquid microextraction (LLME) was developed for extracting sudan dyes from red wine and fruit juice. Room temperature ionic liquid was used as the extraction solvent. The target analytes were determined by high-performance liquid chromatography. The extraction parameters were optimized. The optimal conditions are as follows: volume of [C(6)MIM][PF(6)] 50 μL; the extraction time 10 min; pH value of the sample solution 7.0; NaCl concentration in sample solution 5%. The extraction recoveries for the analytes in red wine and fruit samples are 86.79-108.28 and 68.54-85.66%, whereas RSDs are 1.42-5.12 and 1.43-6.19%, respectively. The limits of detection and quantification were 0.428 and 1.426 ng/mL for sudan I, 0.938 and 3.127 ng/mL for sudan II, 1.334 and 4.445 ng/mL for sudan III, 1.454 and 4.846 ng/mL for sudan IV, respectively. Compared with conventional liquid-liquid extraction (CLLE) and ultrasonic extraction (UE), when LLME was applied, the sample amount was less (LLME: 4 mL; CLLE: 10 mL; UE: 10 mL), the extraction time was shorter (LLME: 15 min; CLLE: 110 min; UE: 50 min) and the extraction solvent amount was less (LLME: 0.05 mL IL; CLLE: 15 mL hexane; UE: 20 mL hexane). The proposed method offers a simple, rapid and efficient sample preparation for determining sudan dyes in red wine and fruit juice samples.     

Hydrothermal decomposition of brominated epoxy resin in waste printed circuit boards

Brominated flame retardant (BFR), which containing in printed circuit boards (WPCBs), brings a series of environmental and health problems. Hydrothermal technology was applied to decompose brominated epoxy resin in WPCBs at subcritical or supercritical water conditions. The brominated epoxy resin was decomposed into oil and the environmental influence of BFR was eliminated. The experiment was carried out in a 5.7 ml tube reactor and heated by a salt-bath. The variation of degradation rate of brominated epoxy resin with reaction temperature, time and additives were studied. The compositions of liquid products were analyzed by gas chromatography-mass spectrometry (GC-MS). When reaction temperature exceeded 300 °C, retention time stayed over 30 min and alkaline additive existed, more than 80% brominated epoxy resin could be mainly decomposed into phenol, which can be used as chemical material. Two different hydrothermal decomposition pathways were discussed according to the characterization of products. The results indicated that brominated epoxy resin in WPCBs could be handled effectively by hydrothermal decomposition.     

Influence of ultrasound treatment on accessibility and regioselective oxidation reactivity of cellulose

Cellulose fibers were treated with ultrasound in order to improve the accessibility and the reactivity of cellulose. The influence of ultrasound treatment on changes of morphology structure, accessibility and oxidation reactivity of cellulose with sodium periodate were discussed. The results revealed an increase in cellulose’s accessibility in terms of water retention value (WRV) with increasing ultrasound treatment time, corresponding to 73.0%, 75.6%, 80.8%, 98.7% and 119.0% after treated for 0, 90, 180, 360 and 720 s, respectively. Furthermore, the regioselective oxidation reactivity of cellulose with sodium periodate was also successfully improved by the ultrasound treatment. However, no significant changes in crystallinity of cellulose were noted after ultrasound treatment. The oxidized products dialdehyde cellulose (DAC) was further characterized by means of FTIR, X-ray diffraction and SEM.     

声波测井技术在非常规致密油藏储层评价中的应用

本文应用声波测井技术,针对松辽盆地齐家-古龙地区,非常规致密油储层有效性评价方法进行研究,即评价可能的裂缝发育段、可能的含油层段和可压裂改造的层段等。针对研究区非常规致密油藏特征及勘探实践,采用声波时差等效深度法建立超压层识别方法,通过计算岩石脆性指数建立岩石易压裂性评价技术。该技术较好的解决了非常规致密油藏储层有效性评价的关键问题,在老井压裂改造和新钻水平井、大斜度井测井评价中发挥雷要作用,见到很好的应用效果。     

非连续数字图像相关方法在裂纹重构中的应用

数字图像相关方法作为一种新的非接触式位移测量方法,在力学工程中有广泛的应用前景,然而受限于标准方法对图像变形的连续性要求,这种高效的测量方法在断裂力学领域的推广受到了限制. 为解决这一问题,提出采用引入子区分离数学模型,代替标准方法的连续模型,来对非连续区域进行精确识别和匹配的非连续数字图像相关方法. 研究子区被裂纹等非连续分割后原始像素点的位移情况,并引入裂纹张开向量用以表征被分割子区的主区和副区的位移关系;从而建立子区分离模型的数学表达式,并且为所提出的模型设计相应的图像相关算法;然后将所提出的非连续数字图像相关方法应用于重构平板拉伸试验开裂过程中图像的位移. 研究结果表明,相比于标准的数字图像相关方法,所提出的非连续数字图像相关方法解决了图像相关法在非连续区域失效的问题,提高了数字图像相关方法对位移测量的正确率,特别是能够准确重构裂纹面及附近的位移场,其测量精度能够达到亚像素级别.      

Upper and lower bounds of Borel–Cantelli Lemma in a general measure space

It is known that the Borel–Cantelli Lemma plays an important role in probability theory. Many attempts were made to generalize its second part. In this article, we investigate the upper and lower bounds of Borel–Cantelli Lemma for the nonnegative functions in a general measure space. Our results extend the corresponding results obtained in a probability space. Some examples including dependent random variables are illustrated to our results.     

前体涡发生器对轴对称高超声速进气道激波振荡流动的影响实验

激波振荡是高超声速进气道不起动过程中常见的流动现象,会显著降低进气道气流捕获与压缩效率、产生剧烈的非定常气动力载荷而危害飞行器安全. 从激波振荡的控制出发,实验研究了前体转捩带位置的涡发生器对轴对称高超声速进气道激波振荡流动的影响. 分别在起动和激波振荡两种进气道流态下,选择无、0.5 mm与1 mm高度涡发生器工况进行对比研究. 并采用高速纹影与壁面动态测压同步记录非定常流动特征. 结果表明,1 mm高度内的涡发生器对起动状态的进气道主流流场结构、壁面压强分布影响不显著. 但对于激波振荡流动,涡发生器会明显缩小外压缩面分离区运动范围,缩短振荡周期,提升振荡周期内壁面压强的时均值. 涡发生器的影响程度随其高度的增大而增强,其中振荡周期从无涡发生器的4 ms缩短到1 mm高度涡发生器的3.13 ms. 此外,0.5 mm高度涡发生器会使得进气道内部测点的压强振荡幅值整体下降,相比无涡发生器工况的下降幅度可达23%. 流场结构与壁面压强信号的分析表明,涡流发生器主要通过其产生的流向涡影响激波振荡流动,包含流向涡对下游边界层的扰动以及流向涡与分离区的相互干扰.