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91.
Jeffery S. Edmiston Jason W. Flora Mariano J. Scian Guoya Li Gaurav S. J. B. Rana Timothy B. Langston Tapas K. Sengupta Willie J. McKinney 《Analytical and bioanalytical chemistry》2009,394(6):1609-1620
Phosphorylation is the most widely studied posttranslational modification (PTM) and is an important regulatory mechanism used
during cellular responses to external stimuli. The kinases and phosphatases that regulate protein phosphorylation are known
to be affected in many human diseases. Cigarette smoking causes cardiovascular disease (CVD). Endothelial cells play a pivotal
role in CVD initiation and development; however, there have been limited investigations of the specific signaling cascades
and protein phosphorylations activated by cigarette smoke in endothelial cells. The purpose of this research was to better
understand the differential protein phosphorylation in endothelial cells stimulated with extracts of cigarette smoke total
particulate matter (CS-TPM) in vitro. Human microvascular endothelial cells were exposed in vitro to CS-TPM at concentrations
that were shown to cause endothelial cell dysfunction. The phosphorylated proteins were isolated using phosphoprotein-specific
chromatography, followed by enzymatic digestion and nano-flow capillary liquid chromatography (ncap-LC) coupled to high resolution
mass spectrometry. This study putatively identified 94 proteins in human microvascular endothelial cells that were differentially
bound to a phosphoprotein-specific chromatography column following exposure to CS-TPM suggesting differential phosphorylation.
Pathway analysis has also been conducted and confirmations of several observations have been made using immunoaffinity-based
techniques (e.g., Western blotting).
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
92.
Chakraborty T Holm AI Hvelplund P Nielsen SB Poully JC Worm ES Williams ER 《Journal of the American Society for Mass Spectrometry》2006,17(12):1675-1680
Electron capture by both bare and microsolvated small peptide dications was investigated by colliding these ions with sodium vapor in an accelerator mass spectrometer to provide insight into processes that occur on the microsecond time frame. Survival of the intact peptide monocation after electron capture depends strongly on molecular size. For dipeptides, no intact reduced species were observed; the predominant ions correspond to loss of hydrogen and ammonia. In contrast, the intact reduced species was observed for larger peptides. Calculated structures indicate that the diprotonated dipeptide ions form largely extended structures with low probability of internal ionic hydrogen bonding (i.e., charge solvation) whereas internal ionic H-bonding occurs extensively for larger peptide dications. Solvation of the peptide ions with between one to seven methanol molecules reduces the total extent of H loss even for dipeptides where intact reduced species can survive more than a microsecond after electron capture. The yield of ions corresponding to cleavage of NCalpha bonds (c+ and z+* ions) does not depend strongly on peptide size but decreases with the extent of microsolvation for the dipeptide dications. H-bonding appears to play an important role for the survival of the intact reduced ions but less so for the formation of c+ and z+* ions. Our results indicate that electron capture predominantly occurs at the ammonium groups (at least 70 to 80%), and provides important new insights into the electron capture dissociation process. 相似文献
93.
An analysis is carried out to study the steady two-dimensional stagnation-point flow and heat transfer of an incompressible viscous fluid over a porous shrinking sheet in the presence of thermal radiation. A set of similarity transformations reduce the boundary layer equations to a set of non-linear ordinary differential equations which are solved numerically using fourth order Runge-Kutta method with shooting technique. The analysis of the result obtained shows that as the porosity parameter β increases, the range of region of existence of similarity solution increases. It is also observed that multiple solutions exist for a certain range of the ratio of the shrinking velocity to the free stream velocity (i.e., α) which again depends on β. We then discuss the stability of the unsteady solutions about each steady solution, showing that one steady state solution corresponds to a stable solution whereas the other corresponds to an unstable solution. The stable solution corresponds to the physically relevant solution. Further we obtain numerical results for each solution, which enable us to discuss the features of the respective solutions. 相似文献
94.
Rao KV Mohapatra S Maji TK George SJ 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(15):4505-4509
A swell idea! The guest-responsive reversible swelling and fluorescence enhancement of a dynamic, microporous polymer network is presented. Guest-induced breathing of hydrophobic pores imparts multi-functional properties, such as super-absorbency, phase-selective swelling of oil from water and encapsulation of C(60) (see figure), to this soft micro-porous organic polymer. 相似文献
95.
P. Mallick D.C. Agarwal Chandana Rath D. Behera D.K. Avasthi D. Kanjilal N.C. Mishra 《Radiation Physics and Chemistry》2012,81(6):647-651
NiO thin films grown on Si (100) substrate by electron beam evaporation method and sintered at 700 °C were irradiated with 200 MeV Au15+ ions. The fcc structure of the sintered films was retained up to the highest fluence (1×1013 ions cm?2) of irradiation. However the microstructure of the pristine film underwent a considerable modification with increasing ion fluence. 200 MeV Au ion irradiation led to compressive stress generation in NiO medium. The diameter of the stressed region created by 200 MeV Au ions along the ion path was estimated from the variation of stress with ion fluence and found to be ~11.6 nm. The film surface started cracking when irradiated at and above the fluence of 3×1012 ions cm?2. Ratio of the fractal dimension of the cracked surface obtained at 200 MeV and 120 MeV (Mallick et al., 2010a) Au ions was compared with the ratio of the radii of ion tracks calculated based on Coulomb explosion and thermal spike models. This comparison indicated applicability of thermal spike model for crack formation. 相似文献
96.
In the bubble model of ortho positronium (o-Ps) annihilation in liquid the origin of the trapping of o-Ps is the electron-exchange repulsive interaction between the electron of o-Ps and the electron of the medium. The corresponding effective interaction is non-local in nature. However, in the prevalent bubble model, this effective interaction is usually treated as local (model) potential (sharp or smooth). In the present study, we have taken an approach to consider this trapping interaction as non-local in nature, which is included through a model separable non-local function to tackle the problem in analytically solvable manner. The analytical calculations show that this non-local interaction effectively acts as a gauge potential in the energy of the Ps atom in parameter (bubble radius) space. The computed bubble variables obtained using experimental Ps annihilation data are shown. A comparison between the present data with the calculated results using prevalent bubble model has been presented. Discussions have been made on the input parameter dependencies of the computed data. 相似文献
97.
SR Rout B Behera TK Maiti S Mohapatra 《Dalton transactions (Cambridge, England : 2003)》2012,41(35):10777-10783
Magnetic mesoporous amorphous calcium phosphate nanoparticles with a size of 62 nm and abundant -COOH groups on the surface have been prepared by a simple method. The particles show excellent aqueous dispersion stability in physiological pH without any deterioration in hydrodynamic size and zetapotential. By virtue of the carboxylate groups on the surface, the platinum pharmacophore cis-diaquadiamine platinum(ii), folic acid and rhodamine isothiocyanate were conjugated on these magnetic calcium phosphate nanoparticles. The cytotoxicity and internalization efficiency of these nanocarriers have been evaluated on folate receptor overexpressed HeLa cells. These drug loaded nanoagents exhibit elevated cytotoxicity and induce apoptosis in HeLa cells. 相似文献
98.
The structure of polymeric carbon dioxide (CO2-V) has been solved using synchrotron x-ray powder diffraction, and its evolution followed from 8 to 65 GPa. We compare the experimental results obtained for a 100% CO2 sample and a 1 mol?% CO2/He sample. The latter allows us to produce the polymer in a pure form and study its compressibility under hydrostatic conditions. The high quality of the x-ray data enables us to solve the structure directly from experiments. The latter is isomorphic to the β-cristobalite phase of SiO2 with the space group I42d. Carbon and oxygen atoms are arranged in CO4 tetrahedral units linked by oxygen atoms at the corners. The bulk modulus determined under hydrostatic conditions, B0=136(10) GPa, is much smaller than previously reported. The comparison of our experimental findings with theoretical calculations performed in the present and previous studies shows that density functional theory very well describes polymeric CO2. 相似文献
99.
We investigate the growth of a crystal that is built by depositing cubes inside a corner. The interface of this crystal approaches a deterministic growing limiting shape in the long-time limit. Building on known results for the corresponding two-dimensional system and accounting for basic three-dimensional symmetries, we conjecture a governing equation for the evolution of the interface profile. We solve this equation analytically and find excellent agreement with simulations of the growth process. We also present a generalization to arbitrary spatial dimension. 相似文献
100.
Igor Dubenko Tapas Samanta Arjun Kumar Pathak Alexandr Kazakov Valerii Prudnikov Shane Stadler Alexander Granovsky Arcady Zhukov Naushad Ali 《Journal of magnetism and magnetic materials》2012
The studies of magnetocaloric properties, phase transitions, and phenomena related to magnetic heterogeneity in the vicinity of the martensitic transition (MT) in Ni–Mn–In and Ni–Mn–Ga off-stoichiometric Heusler alloys are summarized. The crystal structure, magnetocaloric effect (MCE), and magnetotransport properties were studied for the following alloys: Ni50Mn50−xInx, Ni50−xCoxMn35In15, Ni50Mn35−xCoxIn15, Ni50Mn35In14Z (Z=Al, Ge), Ni50Mn35In15−xSix, Ni50−xCoxMn25+yGa25−y, and Ni50–xCoxMn32−yFeyGa18. It was found that the magnetic entropy change, ΔS, associated with the inverse MCE in the vicinity of the temperature of the magneto-structural transition, TM, persists in a range of (125-5) J/(kg K) for a magnetic field change ΔH=5 T. The corresponding temperature varies with composition from 143 to 400 K. The MT in Ni50Mn50−xInx (x=13.5) results in a transition between two paramagnetic states. Associated with the paramagnetic austenite-paramagnetic martensite transition ΔS=24 J/(kg K) was detected for ΔH=5 T at T=350 K. The variation in composition of Ni2MnGa can drastically change the magnetic state of the martensitic phase below and in the vicinity of TM. The presence of the martensitic phase with magnetic moment much smaller than that in the austenitic phase above TM leads to the large inverse MCE in the Ni42Co8Mn32−yFeyGa18 system. The adiabatic change of temperature (ΔTad) in the vicinity of TC and TM of Ni50Mn35In15 and Ni50Mn35In14Z (Z=Al, Ge) was found to be ΔTad=−2 K and 2 K for ΔH=1.8 T, respectively. It was observed that |ΔTad|≈1 K for ΔH=1 T for both types of transitions. The results on resistivity, magnetoresistance, Hall resistivity in some In-based alloys are discussed. 相似文献