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131.
A convergent enantioselective route to an advanced intermediate for the synthesis of the marine natural product (+)-laurencin has been developed. The methodology employs ring-opening of an ephedrine-based spiro-epoxide with a chiral secondary alcohol, hemiacetal allylation and ring closing metathesis as the key steps for elaboration of the functionalized medium-ring ether moiety in laurencin. 相似文献
132.
Chattopadhyay SK Kumar S Tripathi S Kaur R Tandon S Rane S 《Biomedical chromatography : BMC》2008,22(12):1325-1345
A rapid, sensitive and simple reverse-phase high-performance liquid chromatographic-electrospray ionization-mass spectrometry method for simultaneous determination of cleomiscosin A and cleomiscosin B has been developed and validated. The isomeric coumarinolignoids cleomiscosin A (1) and cleomiscosin B (2) were separated on a Waters symmetry C(18) column with a solvent system composed of acetonitrile-methanol (1:2) and acetic acid-water (0.5:99.5) in a gradient elution mode. The absorption at 326 nm was chosen as the measuring wavelength in which resolution and baseline separation of compounds 1 and 2 could be obtained. The identity of the two isomeric compounds 1 and 2 in the samples were determined on a triple quadrupole mass spectrometer with ESI interface operating in the positive mode. Calibration curves were linear (r(2) > 0.993) over the concentration range 20-200 microg/mL for cleomiscosin A and 10-200 microg/mL for cleomiscosin B with acceptable accuracy and precision, respectively. The intra-day and inter-day precision were 1.13 and 0.82% for cleomiscosin A and 1.78 and 1.28% for cleomiscosin B, respectively. The validated method was successfully applied for the analysis of the above two compounds in different extracts of Cleome viscosa. 相似文献
133.
Siddheshwar D. Jadhav Nagnnath D. Kokare Sunil D. Jadhav 《Journal of heterocyclic chemistry》2008,45(5):1461-1464
134.
Maity J Shakya G Singh SK Ravikumar VT Parmar VS Prasad AK 《The Journal of organic chemistry》2008,73(14):5629-5632
Candida antarctica lipase-B (CAL-B) immobilized on lewatite selectively acylated the primary hydroxyl group of the furanosyl nucleoside in a mixture of 1-(alpha-D-arabinofuranosyl)thymine and 1-(alpha-D-arabinopyranosyl)thymine. This selective biocatalytic acylation of furanosyl nucleoside has enabled us an easy separation of arabinofuranosyl thymine from an inseparable mixture with arabinopyranosyl thymine. The primary hydroxyl selective acylation methodology of arabinonucleoside has also been successfully used for the separation of 1-(beta-D-xylofuranosyl)thymine and 1-(beta-D-xylopyranosyl)thymine from a mixture of the two, which demonstrate the generality of the enzymatic methodology for separation of furanosyl and pyranosyl nucleosides. 相似文献
135.
Sunil Sharma 《Tetrahedron letters》2008,49(49):7062-7065
A mild, efficient, and one-pot protocol for the intramolecular cyclization of 2-substituted nitroarenes via C-N bond formation using SnCl2·2H2O is described. The versatility of the method has been demonstrated by synthesizing two sets of polycyclic structures based on privileged structures of indole and pyrrole, and of the alkaloid cryptotackieine associated with antimalarial activity. Our new approach provides a powerful entry into polycyclic structures related to an alkaloid. 相似文献
136.
Sunil K. Ghosh 《Helvetica chimica acta》2023,106(11):e202300141
Acrylates are well known electrophilic alkenes having multitude of applications in organic synthesis. They are very good acceptors in Michael addition reactions and are good enophile/dienophile/dipolarophile partners in cycloaddition reactions. Replacing the β-alkyl/aryl groups in acrylates by a silicon group would be interesting. In addition to the conventional reactions displayed by acrylates, β-silylacrylates (β-SAs) can show reactivity specifically related to the silicon group. Many conventional organic reactions such as hydrodimerization, organocatalytic asymmetric Michael additions, inter- and intra-molecular Diels–Alder reactions, and asymmetric 1,3-dipolar cycloadditions have been used to generate the complex chemical entities from β-SAs. Some of the reaction outcomes were vastly influenced by the silicon substituent. This review describes the practical synthesis β-SAs and their use as starting point in complex molecule generation including total synthesis of some natural products/bioactive molecules. 相似文献
137.
Sunil K. Chebolu J. Daniel Christensen Já n Miná c 《Proceedings of the American Mathematical Society》2008,136(4):1171-1179
A ghost in the stable module category of a group is a map between representations of that is invisible to Tate cohomology. We show that the only non-trivial finite -groups whose stable module categories have no non-trivial ghosts are the cyclic groups and . We compare this to the situation in the derived category of a commutative ring. We also determine for which groups the second power of the Jacobson radical of is stably isomorphic to a suspension of .
138.
Prabhakar N Arora K Arya SK Solanki PR Iwamoto M Singh H Malhotra BD 《The Analyst》2008,133(11):1587-1592
Cysteine modified NH(2)-end peptide nucleic acid (PNA) (24-mer) probe and 5'-thiol end labeled deoxyribonucleic acid (DNA) probes specific to Mycobacterium tuberculosis have been immobilized onto BK-7 gold coated glass plates for the detection of complementary, one-base mismatch, non-complementary targets and complementary target sequence in genomic DNA of Mycobacterium tuberculosis using a surface plasmon resonance (SPR) technique. The DNA/Au and PNA/Au bio-electrodes have been characterized using contact angle, atomic force microscopy (AFM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetric (CV) techniques, respectively. It is revealed that there is a 252 millidegrees SPR angle change in the case of PNA immobilization and 205 millidegrees for DNA immobilization, indicating increased amount of immobilized PNA molecules. Hybridization studies reveal that there is no binding of the non-complementary target to DNA/Au and PNA/Au electrode. Compared to the DNA/Au bioelectrode, PNA/Au electrode has been found to be more efficient for detection of one-base mismatch sequence. The PNA/Au bioelectrode shows better detection limit (1.0 ng ml(-1)) over the DNA-Au bioelectrode (3.0 ng ml(-1)). The values of the association (k(a)) and dissociation rate constant (k(d)) for the complementary sequence in case of the PNA/Au bioelectrode have been estimated as 8.5 x 10(4) m(-1) s(-1) and 3.6 x 10(-3) s(-1), respectively. 相似文献
139.
Undare Santosh S. Valekar Navnath J. Patravale Ajinkya A. Jamale Dattatraya K. Vibhute Sunil S. Walekar Laxman S. Kolekar Govind B. Deshmukh M. B. Anbhule Prashant V. 《Research on Chemical Intermediates》2016,42(5):4373-4386
Research on Chemical Intermediates - A simple methodology has been developed for the synthesis of diverse members of multifunctionalized 4-hydroxy-2-methyl-6-(phenyl)pyrimidine-5-carbonitrile... 相似文献
140.
We consider a coupled system of first-order singularly perturbed quasilinear differential equations with given initial conditions. The leading term of each equation is multiplied by a distinct small positive parameter, which induces overlapping layers. The quasilinear system is discretized by using first and second order accurate finite difference schemes for which we derive general error estimates in the discrete maximum norm. As consequences of these error estimates we establish nodal convergence of O((N ?1 lnN) p ),p=1,2, on the Shishkin mesh and O(N ?p ),p=1,2, on the Bakhvalov mesh, where N is the number of mesh intervals and the convergence is robust in all of the parameters. Numerical computations are included which confirm the theoretical results. 相似文献