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571.
Hashim P Sidek H Helan MH Sabery A Palanisamy UD Ilham M 《Molecules (Basel, Switzerland)》2011,16(2):1310-1322
Leaves of Centella asiatica (Centella) were analysed for their triterpene composition and bioactivity such as collagen enhancement, antioxidant, anticellulite and UV protection capacity properties. Triterpenes of Centella were measured using HPLC-PAD on an Excil ODS 5 mm (C18) column for the simultaneous determination of asiatic acid, madecassic acid, asiaticoside and madecassoside. Centella was found to contain significant amounts of madecassoside (3.10 ± 4.58 mg/mL) and asiaticoside (1.97 ± 2.65 mg/mL), but was low in asiatic and madecassic acid. The highest collagen synthesis was found at 50 mg/mL of Centella extracts. The antioxidant activity of Centella (84%) was compared to grape seed extract (83%) and Vitamin C (88%). Its lipolytic activity was observed by the release of glycerol (115.9 μmol/L) at 0.02% concentration. Centella extracts exhibited similar UV protection effect to OMC at 10% concentration. In view of these results, the potential application of Centella in food and pharmaceutical industries is now widely open. 相似文献
572.
Vasireddy S Ganguly S Sauer J Cook W Spivey JJ 《Chemical communications (Cambridge, England)》2011,47(2):785-787
The direct gas phase catalytic oligomerization of methane at temperatures ≤673 K has been demonstrated using AlBr(3)-HBr superacid. The reaction produces C(2)+ hydrocarbons and hydrogen in a single step at 1 atm in a continuous flow reactor at a nominal residence time of 60 s. The essentially complete conversion of methane appears to be due to protolytic activation of methane in the presence of H(+)AlBr(4)(-). 相似文献
573.
Natarajan Thillai Sivakumar Bajaj Hari C. Tayade Rajesh J. 《Journal of nanoparticle research》2014,16(11):1-16
The pharmacokinetics (PK) of carrier-mediated agents (CMA) is dependent upon the carrier system. As a result, CMA PK differs greatly from the PK of small molecule (SM) drugs. Advantages of CMAs over SMs include prolonged circulation time in plasma, increased delivery to tumors, increased antitumor response, and decreased toxicity. In theory, CMAs provide greater tumor drug delivery than SMs due to their prolonged plasma circulation time. We sought to create a novel PK metric to evaluate the efficiency of tumor and tissue delivery of CMAs and SMs. We conducted a study evaluating the plasma, tumor, liver, and spleen PK of CMAs and SMs in mice bearing subcutaneous flank tumors using standard PK parameters and a novel PK metric entitled relative distribution over time (RDI-OT), which measures efficiency of delivery. RDI-OT is defined as the ratio of tissue drug concentration to plasma drug concentration at each time point. The standard concentration versus time area under the curve values (AUC) of CMAs were higher in all tissues and plasma compared with SMs. However, 8 of 17 SMs had greater tumor RDI-OT AUC0–last values than their CMA comparators and all SMs had greater tumor RDI-OT AUC0–6 h values than their CMA comparators. Our results indicate that in mice bearing flank tumor xenografts, SMs distribute into tumor more efficiently than CMAs. Further research in additional tumor models that may more closely resemble tumors seen in patients is needed to determine if our results are consistent in different model systems. 相似文献
574.
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576.
Caradee Y. Wright Colette Brogniez Katlego P. Ncongwane Venkataraman Sivakumar Gerrie Coetzee Jean‐Marc Metzger Frédérique Auriol Christine Deroo Béatrice Sauvage 《Photochemistry and photobiology》2013,89(5):1226-1233
To estimate potential sunburn risk for schoolchildren and outdoor workers, ground‐based ambient solar ultraviolet radiation (UVR) measurements were converted into possible child (5% of ambient solar UVR) and outdoor worker (20% of ambient solar UVR) solar UVR exposures by skin type and season for three coastal sites: Durban, Cape Point (South Africa) and Saint Denis (Reunion Island, France). Cumulative daily ambient solar UVR levels were relatively high at all sites, especially during summer, with maximum values of about 67, 57 and 74 Standard Erythemal Dose (SED) (1 SED = 100 J m?2) at Durban, Cape Point and Saint Denis respectively. Sunburn risk was evident for both children and outdoor workers, especially those with skin types I and II (extremely to moderately sensitive) during summer, early autumn and/or late spring at all three sites. Although results need to be verified with real‐time, instantaneous and nonintegrated personal solar UVR measurements, this understanding of sunburn risk is useful for initiating the development skin cancer prevention and sun protection awareness campaigns in both countries. 相似文献
577.
Highly regiospecific mononitration of phenols and substituted phenols is accomplished by employing copper(II) nitrate supported on a catalytic amount of zeolite H‐Y in a solid state. 相似文献
578.
579.
N. Kanagathara M. K. Marchewka N. Sivakumar K. Gayathri N. G. Renganathan S. Gunasekaran G. Anbalagan 《Journal of Thermal Analysis and Calorimetry》2013,112(3):1317-1323
Single crystals of melaminium perchlorate monohydrate (MPM) have been grown from aqueous solution by slow solvent evaporation method at room temperature. X-ray powder diffraction analysis confirms the title crystal crystallizes in the triclinic (P-1) structure and the calculated lattice parameters are a = 5.6275 ± 0.0780 Å, b = 7.6926 ± 0.1025 Å, c = 12.0878 ± 0.2756 Å, α = 103.89 ± 1.01°, β = 94.61 ± 0.92°, γ = 110.22 ± 0.81°, and V = 468.95 Å3. The thermal decomposition behavior of MPM has been studied by means of thermogravimetric analysis at three different heating rates 5, 10, and 20 °C min?1. The values of effective activation energy (E a), pre-exponential factor (ln A) of each stage of thermal decomposition for all heating rates were calculated by model free method: Kissinger, Kim–Park, and Flynn–Wall method. A significant variation of effective activation energy (E a) with conversion (α) indicates that the process is kinetically complex. The linear relationship between the A and E a values was established (compensation effect). Dielectric study has also been carried out and it is found that both dielectric constant (ε′) and dielectric loss (ε″) decreases with increase in frequency. 相似文献
580.
An efficient, convenient, and novel one-pot method of 2,4,5-triaryl-1H-imidazoles synthesis using benzil, arene carbaldehydes, and ammonium acetate, catalyzed by uranyl nitrate hexahydrate [UO2(NO3)2·6H2O] supported on acidic alumina and resulting in good to excellent yields under heterogeneous conditions, is reported. Formation
of a reactants-catalyst complex was confirmed by UV-VIS spectral data. Antibacterial (MIC) and antioxidant activity of the
synthesized compounds was also studied. 相似文献