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91.
An effective strategy for the synthesis of N-2-substituted-1,2,3-triazoles with excellent yields and regioselectivity has been developed. 相似文献
92.
A biocomposite material of hyaluronic acid (HA) and room temperature ionic liquid, 1‐butyl‐3‐methyl‐imidazolium tetrafluoroborate (BMIMBF4) was fabricated and characterized by voltammetry and electrochemical impedance spectroscopy. Hemoglobin (Hb), as a model protein, was immobilized in this biocomposite on glassy carbon electrode to investigate its direct electrochemistry. A pair of well‐defined, quasireversible cyclic voltammetric peaks appeared with the formal potentials (E°′) at ?0.360 V (vs. SCE). The Hb modified electrode exhibited an excellent electrocatalytic activity to the reduction of H2O2 with a wide linear range, good selectivity, sensitivity and reproducibility, which had potential application to fabrication the third‐generation biosensor. 相似文献
93.
Hai Hu Wenjun Xiao Jian Yuan Jianwei Shi Dannong He Wenfeng Shangguan 《Journal of Sol-Gel Science and Technology》2008,45(1):1-8
A set of anatase titanium dioxide (TiO2) films coated on foam nickel that modified by Al2O3 films as transition layer (indicated as TiO2/Al2O3 films) were synthesized via sol-gel route. The bulk and surface properties of the TiO2/Al2O3 films were characterized by thermal gravimetric and differential scanning calorimetry (TG-DSC), X-ray diffraction (XRD),
field-emission scanning electron microscope (FE-SEM), and BET. The photocatalytic activities of TiO2/Al2O3 films were investigated based on the degradation of gaseous acetaldehyde under ultraviolet (UV) irradiation. The foam nickel
is a promising substrate material in practical applications because of its excellent hydrodynamic properties for gas passing.
The TiO2/Al2O3 composite films showed much higher photocatalytic activity and stability for degradation of gaseous acetaldehyde than the
onefold TiO2 films. The significant enhancement in photocatalytic activity and stability can be ascribed to the coating of Al2O3 transition layer, which concentrates the target substances around TiO2 particles and increases the specific surface area (SSA) of the substrate (the SSAs of bare foam nickel and Al2O3 modified foam nickel are 0.12 and 113.7 m2/g, respectively) to provide more sites for TiO2 loading. 相似文献
94.
Qidi Ren Lu Wang Wenfei Qian Baiqiu Chen Qi Shuai Yunfeng Yan 《Macromolecular bioscience》2023,23(7):2300085
RNA interference (RNAi) is a promising approach for disease treatments. But the development of safe and effective delivery carriers remains a major challenge. Organic–inorganic hybrid nanoparticles (NPs), with the integration of functions from distinct materials, show great potential in small interfering RNA (siRNA) delivery. Herein, pH responsive amorphous calcium carbonate NPs (ACC NPs) are prepared using flash nanoprecipitation and hybrid NPs are constructed by coating ACC NPs with polyethyleneimine (PEI) for efficient siRNA delivery. PEI/ACC NPs show robust pH responsiveness and stability as well as effective siRNA loading and protection. Furthermore, siRNA-loaded PEI/ACC NPs demonstrate enhanced cellular uptake and efficient endosomal escape, mediating improved siRNA delivery compared to pure PEI. These findings suggest that PEI/ACC NPs may have great potential in siRNA delivery for RNAi-based therapy. 相似文献
95.
Chiral lactic acid and its ester derivatives are crucial building blocks and platforms in the generation of high value-added drugs, fine chemicals and functional materials. Optically pure D-lactic acid and its ester derivatives cannot be directly generated from fermentation and are quite expensive. Herein, we identified, heterologously expressed and functionally characterized one Bacillus esterase BSE01701 from the deep sea of the Indian Ocean. Esterase BSE01701 could enzymatically resolve inexpensive racemic methyl lactate and generate chiral D-methyl lactate. The enantiomeric excess of desired chiral D-methyl lactate and the substrate conversion could reach over 99 % and 60 %, respectively, after process optimization. Notably, the addition of 60 % (v/v) organic co-solvent heptane could greatly improve both the enantiomeric excess of D-methyl lactate and the conversion. BSE01701 was a very promising marine microbial esterase in the generation of chiral chemicals in industry. 相似文献
96.
97.
The absolute position of an underwater target is difficult to pinpoint because the global positioning system (GPS) cannot penetrate water bodies. The long baseline (LBL) positioning system can extend GPS using high-precision calibrated underwater beacons as references. While traditional LBL systems give the target position without considering calibration error of deployed beacons. To solve this problem, we propose a method different from previous works, that combining the errors of observations together. We use GPS outputs as true values to evaluate the localization performance. An LBL system with four beacons was installed in deep sea to test the results. The positioning accuracy in deep sea improves nearly 5 m. The results suggest that beacon positioning errors have a great impact on localization precision, that is significant in high-precision positioning tasks. 相似文献
98.
Qi Duan Huanling Zhang Yunfeng Zhang E.H. Twizell 《Journal of Computational and Applied Mathematics》2007
This paper deals with the approximation properties of a kind of rational spline with linear denominator when the function being interpolated is C3 in an interpolating interval. Error estimate expressions of interpolating functions are derived, convergence is established, the optimal error coefficient, ci, is proved to be symmetric about the parameters of the rational interpolation and it is bounded. Finally, the precise jump measurements of the second derivatives of the interpolating function at the knots are given. 相似文献
99.
Anthramycin is a benzodiazepine alkaloid with potent antitumor and antibiotic activity produced by the thermophilic actinomycete Streptomyces refuineus sbsp. thermotolerans. In this study, the complete 32.5 kb gene cluster for the biosynthesis of anthramycin was identified by using a genome-scanning approach, and cluster boundaries were estimated via comparative genomics. A lambda-RED-mediated gene-replacement system was developed to provide supporting evidence for critical biosynthetic genes and to validate the boundaries of the proposed anthramycin gene cluster. Sequence analysis reveals that the 25 open reading frame anthramycin cluster contains genes consistent with the biosynthesis of the two halves of anthramycin: 4 methyl-3-hydroxyanthranilic acid and a "dehydroproline acrylamide" moiety. These nonproteinogenic amino acid precursors are condensed by a two-module nonribosomal peptide synthetase (NRPS) terminated by a reductase domain, consistent with the final hemiaminal oxidation state of anthramycin. 相似文献
100.
1.3μm波长光纤偏振参数自动测试仪 总被引:7,自引:1,他引:6
本文介绍一种用于1.3μm波长的光纤偏振参数自动测试仪。它利用光路集成封装和计算机自动控制及信号处理等关键技术,方便、可靠、自动地进行1.3μm光纤及其器件偏振参数的测试,对于消光比为40dB以下的偏振态测量,误差优于0.3dB. 相似文献