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31.
Jinny Claire Lee Hye Yun Kim Sejin Lee Jisu Shin Hyunjin Vincent Kim Kyeonghwan Kim Seungyeop Baek Donghee Lee Hanna Jeon DaWon Kim Seung‐Hoon Yang Gyoonhee Han Keunwan Park Jaeho Choi Jinwoo Park Jason A. Moss Kim D. Janda YoungSoo Kim 《Angewandte Chemie (International ed. in English)》2020,59(28):11491-11500
Amyloid‐β (Aβ) oligomers are implicated in Alzheimer disease (AD). However, their unstable nature and heterogeneous state disrupts elucidation of their explicit role in AD progression, impeding the development of tools targeting soluble Aβ oligomers. Herein parallel and anti‐parallel variants of Aβ(1–40) dimers were designed and synthesized, and their pathogenic properties in AD models characterized. Anti‐parallel dimers induced cognitive impairments with increased amyloidogenesis and cytotoxicity, and this dimer was then used in a screening platform. Through screening, two FDA‐approved drugs, Oxytetracycline and Sunitinib, were identified to dissociate Aβ oligomers and plaques to monomers in 5XFAD transgenic mice. In addition, fluorescent Astrophloxine was shown to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of AD mice. This screening platform provides a stable and homogeneous environment for observing Aβ interactions with dimer‐specific molecules. 相似文献
32.
Dr. Santosh K. Singh Jesse La Jeunesse Vasant Vuppuluri Prof. Steven F. Son Dr. Bing-Jian Sun Mr. Yue-Lin Chen Prof. Agnes H. H. Chang Prof. Alexander M. Mebel Prof. Dr. Ralf I. Kaiser 《Chemphyschem》2020,21(9):837-842
Understanding of the fundamental mechanisms involved in the decomposition of 1,3,5-trinitro-1,3,5-triazinane (RDX) still represents a major challenge for the energetic materials and physical (organic) chemistry communities mainly because multiple competing dissociation channels are likely involved and previous detection methods of the products are not isomer selective. In this study we exploited a microsecond pulsed infrared laser to decompose thin RDX films at 5 K under mild conditions to limit the fragmentation channels. The subliming decomposition products during the temperature programed desorption phase are detected using isomer selective single photoionization time-of-flight mass spectrometry (PI-ReTOF-MS). This technique enables us to assign a product signal at m/z=42 to ketene (H2CCO), but not to diazomethane (H2CNN; 42 amu) as speculated previously. Electronic structure calculations support our experimental observations and unravel the decomposition mechanisms of RDX leading eventually to the elusive ketene (H2CCO) via an exotic, four-membered ring intermediate. This study highlights the necessity to exploit isomer-selective detection schemes to probe the true decomposition products of nitramine-based energetic materials. 相似文献
33.
Isomers based on the bisindolylmaleimide architecture were reported in this Letter. Introducing hydroxyl to this architecture lead to quenching the fluorescence of bisindolylmaleimide. The fluorescence was recovered with its hydroxyl group esterified. Ester group can be easily transformed to hydroxyl group by hydrolysis reaction. Thus, a toggle-switchable fluorescence, ‘off-on’ cycle can be established on the basis of reversible esterification/hydrolysis reaction. 相似文献
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35.
Lyun-Su Kim Ki-dong Son Debasish Sarker Ji Hwan Jeong Sung Hong Lee 《Heat and Mass Transfer》2011,47(2):163-180
Small vapor compression refrigeration systems incorporate a non-adiabatic capillary tube called a capillary tube-suction line
heat exchanger (SLHX) in order to improve performance. The thermodynamic properties of the refrigerant in the capillary tube
and suction pipe are influenced by associated phenomena. This study compares various relevant models. Based on the comparison
recommended correlations were selected and the simulation results show that the friction factor model has the most dominant. 相似文献
36.
Recognizing and responding to students' thinking is essential in teaching mathematics, especially when students provide incorrect solutions. This study examined, through a teaching scenario task, elementary preservice teachers' interpretations of and responses to a student's work on a task involving reflective symmetry. Findings revealed that a majority of preservice teachers identified the student's errors from conceptual aspects of reflection rather than from procedural aspects. However, when they responded to the student's errors, preservice teachers tried to cope with them by invoking procedural knowledge. This study also revealed the three types of responses and two different forms of address by preservice teachers to student errors; these categories might provide insight into the difficulties arising in communication between students and teachers. 相似文献
37.
Catalytic one-pot synthesis of fenestrane derivatives from dienediynes was developed: fenestranes were synthesized in high yields by a dicobalt octacarbonyl-catalyzed tandem cycloaddition of dienediynes. 相似文献
38.
N-Phenyl alkyl amides were synthesized by the cobalt on charcoal-catalyzed one-pot reaction of alkene and aniline under carbon monoxide; this is the first heterogeneous catalytic formation of N-phenyl alkyl amides. 相似文献
39.
We point out that, in analogy with spin waves in antiferromagnets, all parameters describing the real-time propagation of soft pions at temperatures below the QCD chiral phase transition can be expressed in terms of static correlators. This allows, in principle, the determination of the soft pion dispersion relation on the lattice. Using scaling and universality arguments, we determine the critical behavior of the parameters of pion propagation. We predict that, when the critical temperature is approached from below, the pole mass of the pion drops despite the growth of the pion screening mass. This fact is attributed to the decrease of the pion velocity near the phase transition. 相似文献
40.