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61.
Summary Complexes of formula [MCl3(glyH)3] (M=Ti, V and Fe) [CrCl3(glyH)2H2O], [MCl2(glyH)2(H2O)2] (M=Co and Cu) and [NiCl2(glyH)3H2O] have been prepared and characterized by potentiometric curves, chemical analysis, magnetic properties, i.r. and electronic spectral data. 相似文献
62.
Determination of pirimicarb and endosulfan in commercial pesticide formulations by Fourier transform infrared spectrometry 总被引:1,自引:0,他引:1
Quintás G Moros J Armenta S Garrigues S de la Guardia M 《Journal of AOAC International》2005,88(2):399-405
A routine method based on Fourier transform infrared spectrometry was developed for the simultaneous determination of pirimicarb and endosulfan in commercially available pesticide formulations. The method is based on peak area absorbance measurements between 1362 and 1352 cm(-1), corrected with a baseline fixed at 1338 cm(-1), for pirimicarb and peak area absorbance measurements between 919 and 909 cm(-1) with a baseline fixed at 931 cm(-1) for endosulfan; chloroform solutions for analysis were obtained by direct dilution of emulsifiable concentrates or by solvent extraction from solid samples. Various extraction conditions and appropriate band selection were investigated, and interference studies were performed. Under the experimental conditions selected, limits of detection of 13 microg/g for pirimicarb and 150 microg/g for endosulfan were obtained that correspond to 0.13 and 1.6% (w/w), respectively, in commercial samples. Results from analyses of commercial samples by the developed method compared well with those obtained by a liquid chromatography reference method. 相似文献
63.
Maria-Agustina Rossi Veronica Martinez Philip Hinchliffe Maria F. Mojica Valerie Castillo Diego M. Moreno Ryan Smith Brad Spellberg George L. Drusano Claudia Banchio Robert A. Bonomo James Spencer Alejandro J. Vila Graciela Mahler 《Chemical science》2021,12(8):2898
Infections caused by multidrug resistant (MDR) bacteria are a major public health threat. Carbapenems are among the most potent antimicrobial agents that are commercially available to treat MDR bacteria. Bacterial production of carbapenem-hydrolysing metallo-β-lactamases (MBLs) challenges their safety and efficacy, with subclass B1 MBLs hydrolysing almost all β-lactam antibiotics. MBL inhibitors would fulfil an urgent clinical need by prolonging the lifetime of these life-saving drugs. Here we report the synthesis and activity of a series of 2-mercaptomethyl-thiazolidines (MMTZs), designed to replicate MBL interactions with reaction intermediates or hydrolysis products. MMTZs are potent competitive inhibitors of B1 MBLs in vitro (e.g., Ki = 0.44 μM vs. NDM-1). Crystal structures of MMTZ complexes reveal similar binding patterns to the most clinically important B1 MBLs (NDM-1, VIM-2 and IMP-1), contrasting with previously studied thiol-based MBL inhibitors, such as bisthiazolidines (BTZs) or captopril stereoisomers, which exhibit lower, more variable potencies and multiple binding modes. MMTZ binding involves thiol coordination to the Zn(ii) site and extensive hydrophobic interactions, burying the inhibitor more deeply within the active site than d/l-captopril. Unexpectedly, MMTZ binding features a thioether–π interaction with a conserved active-site aromatic residue, consistent with their equipotent inhibition and similar binding to multiple MBLs. MMTZs penetrate multiple Enterobacterales, inhibit NDM-1 in situ, and restore carbapenem potency against clinical isolates expressing B1 MBLs. Based on their inhibitory profile and lack of eukaryotic cell toxicity, MMTZs represent a promising scaffold for MBL inhibitor development. These results also suggest sulphur–π interactions can be exploited for general ligand design in medicinal chemistry.Metallo-β-lactamases (MBLs) are major culprits of resistance to carbapenems in bacteria. A series of thiazolidines are potent MBL inhibitors, restoring the activity of carbapenems. Metal binding and sulphur–π interactions are key to inhibition. 相似文献
64.
Christian Borgs Roman Kotecký Salvador Miracle-Solé 《Journal of statistical physics》1991,62(3-4):529-551
Recently, Borgs and Kotecký developed a rigorous theory of finite-size effects near first-order phase transitions. Here we apply this theory to the ferromagneticq-state Potts model, which (forq large andd2) undergoes a first-order phase transition as the inverse temperature is varied. We prove a formula for the internal energy in a periodic cube of side lengthL which describes the rounding of the infinite-volume jumpE in terms of a hyperbolic tangent, and show that the position of the maximum of the specific heat is shifted by
m
(L)=(Inq/E)L
–d
+O(L
–2d
) with respect to the infinite-volume transition point
t
. We also propose an alternative definition of the finite-volume transition temperature
t
(L) which might be useful for numerical calculations because it differs only by exponentially small corrections from
t
. 相似文献
65.
S. Barlag H. Becker A. Bożek T. Böhringer M. Bosman V. Castillo V. Chabaud C. Damerell C. Daum H. Dietl A. Gillman R. Gilmore T. Gooch L. Görlich P. Gras Z. Hajduk E. Higon D. P. Kelsey R. Klanner S. Kwan B. Lücking G. Lütjens G. Lutz J. Malos W. Männer E. Neugebauer H. Pałka M. Pepé J. Richardson K. Rybicki H. J. Seebrunner U. Stierlin H. G. Tiecke G. Waltermann S. Watts P. Weilhammer F. Wickens L. W. Wiggers M. Witek T. Zeludziewicz 《Zeitschrift fur Physik C Particles and Fields》1992,55(3):383-390
We combine highly complementary information on branching fractions of charmed mesonsD 0,D + andD s + coming from two experiments both yielding doublecharm samples. The NA 32 experiment provided exclusive branching fractions for channels with at least two charged decay products while a recent Mark III paper provides results on inclusive charm decay properties. The knowledge of channels withK 0's in the former is used to recalculate the charged multiplicity distribution in the latter. We obtain 〈n ch〉=2.25±0.08 forD 0, 〈n ch〉=1.96±0.08 forD + and 〈n ch〉=2.41±0.38 forD s + . In turn the knowledge of the charged multiplicity improves the overall normalization of exclusive branching fractions. This reanalysis yields model-independent results for charmed mesons. In particular we obtain branching fractions for 16D s + decay channels including $$BF(D_s^ + \to \phi \pi ^ + ) = \left( {4.4\begin{array}{*{20}c} { + 2.3} \\ { - 1.8} \\ \end{array} } \right)\% .$$ . 相似文献
66.
S. Barlag H. Becker T. Böhringer M. Bosman V. Castillo V. Chabaud C. Damerell C. Daum H. Dietl A. Gillman R. Gilmore T. Gooch L. Görlich P. Gras Z. Hajduk E. Higon D. P. Kelsey R. Klanner S. Kwan B. Lücking G. Lütjens G. Lütz J. Malos W. Männer E. Neugebauer H. Palka M. Pepé J. Richardson K. Rybicki H. J. Seebrunner U. Stierlin H. G. Tiecke G. Waltermann S. Watts P. Weilhammer F. Wickens L. W. Wiggers M. Witek T. Zeludziewicz 《Zeitschrift fur Physik C Particles and Fields》1991,49(4):555-562
We have studied the hadronic production of charmed mesons in the NA 32 experiment at CERN. A special trigger together with a high resolution vertex detector consisting of charge coupled devices and silicon microstrip detectors allowed the selection of very clean samples of charmed mesons. We have collected 852 fully reconstructed decays: 60D s + →K + K ?π+, 543D°→K ?π+ andK ?π+π?π+ as well as 249D +→K ?π+π+ (or charge conjugate). 147 mesons out of our \({{D^0 } \mathord{\left/ {\vphantom {{D^0 } {\bar D^0 }}} \right. \kern-0em} {\bar D^0 }}\) sample were produced via chargedD * state. For all charmed mesons we determine the total production cross-section and study thex F andp t 2 distributions. 相似文献
67.
Castillo JF Aoiz FJ Bañares L Martinez-Nuñez E Fernandez-Ramos A Vazquez S 《The journal of physical chemistry. A》2005,109(38):8459-8470
An ab initio interpolated potential energy surface (PES) for the F + CH4 reactive system has been constructed using the interpolation method of Collins and co-workers. The ab initio calculations have been performed using second-order M?ller-Plesset (MP2) perturbation theory to build the initial PES. Scaling all correlation (SAC) methodology has been employed to improve the ab initio calculations and to construct a dual-level PES. Using this PES, a detailed quasiclassical trajectory study of integral and differential cross sections, product rovibrational populations and internal energy distributions has been carried out for the F + CH4 and F + CD4 reactions and the theoretical results have been compared with the available experimental data. 相似文献
68.
In this paper an enzymatic fluorometric sensor for glucose determination in drinks is presented. The sensor film was obtained by immobilisation of glucose oxidase chemically modified with a fluorescein derivative (GOx-FS) in a polyacrylamide polymer. During the enzymatic reaction the changes in the fluorescence intensity of the GOx-FS are related to the glucose concentration. Working in FIA mode, the optimum conditions found were: 0.7 ml min(-1) flow rate, 300 mul sample injection and pH 6.5. The sensor responds to glucose concentrations ranging from 400 to 2000 mg l(-1), the reproducibility is around 3% and the life-time is at least 3 months (more than 350 measurements). The sensor was applied to direct glucose determination in drinks with good accuracy; interference caused by the filter effect was avoided by the kinetics of the reaction. 相似文献
69.
Andrés G. León Ana I. Olives M. Antonia Martín Benito del Castillo 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):577-583
The use of cyclodextrins (CDs) in HPLC as mobile phase additives provides a flexible alternative for the separation of chemically
related compounds because these separations can be performed on conventional columns and are economically advantageous over
the use of chiral stationary phases. The present paper describes the influence of the presence of β-cyclodextrin (β-CD) and
2-hydroxypropyl-β-cyclodextrin (HPβ-CD) on the separation of the β-carboline alkaloids norharmane, harmane and harmine. The
nature of the stationary phase (reverse phases C1 and C18) affects the chromatographic separations and also the stability of the inclusion complexes that are developed. The changes
in the proportion of the organic solvents at constant concentration of CDs (3 mM for β-CD and 15 mM for HPβ-CD) modify the
retention factors (k′) for all alkaloids studied. The nature of the organic solvent in the mobile phase also changes the chromatographic parameters.
The logarithm of the capacity factor (k′) is linearly increased with the proportion of water in the hydro-organic mobile phase (ethanolic or methanolic) but the
slopes obtained vary depending on the CD added to the mobile phase. The role of competitive equilibria, i.e., chromatographic
distribution and inclusion complexes formation is discussed.
This paper was presented at XIIIth International Cyclodextrin Symposium. Torino, Italy, May, 14–17, 2006 相似文献
70.