Study of nitrogen- and sulfur-containing heterocycles. 46. New heterocyclic systems — Derivatives of pyrido[3′,2′∶5,6][1,4]thiazino[3,4-c]- and pyrimido-[5′,4′∶5,6][1,4]thiazino[3,4-c][1,2,4]triazines. Synthesis,properties

Representatives of new heterocyclic systems were obtained — pyrido[3,25,6][1,4]thiazino[3,4-c]- and pyrimido[5,45,6][1,4]thiazino[3,4-c][1,2, 4]triazines. Hydrazides of N-(pyrid-3-yl)- and N-(pyrimid-5-yl)oxamic acids were isolated and characterized. Their acylation products were investigated.For communication 45, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 559–562, April, 1993.     

Investigation of nitrogen-and sulfur-containing heterocycles

Reaction of 4-chloro-5-hydroxy-6-aminopyrimidine and its 2-methyl derivatives with -chloroacetoacetic ester gave the corresponding 4-chloro-6-carbethoxy-8H-pyrimido-[5,4-b][1,4]oxazines, which were converted to 4-aminopyrimidooxazines by reaction with amines.See [1] for communication XXVIII.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1694–1696, December, 1973. Original article submitted.     

A study of nitrogen- and oxygen-containing heterocycles. 42. Pyrimido[4,5-b]- and pyrido[2,3-b]-1,4-benzoxazepines

The reaction of o-haloamino derivatives of pyrimidine and pyridine with o-hydroxy-benzaldehyde and its derivatives leads to the formation of tricyclic 1,4-oxazepine systems. Syntheses are reported for derivatives of pyrimido[4,5-b]- and pyrido[2, 3-b]-1,4-benzoxazepines as well as of their 5,6-dihydro derivatives. The properties and structures of these compounds were studied.For Communication 41, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 122–125, January, 1985.     

Nitrogen- and sulfur -containing heterocycles

A number of derivatives of pyrimido [4, 5-b]-[1, 4]-6-thiazinone have been obtained by the reaction of 2, 5-diamino-4-methyl-6-mercapto-and 4-methoxy-5-amino-6-mercaptopyrimidines with -halo acids.     

An investigation of nitrogen- and sulfur-containing heterocycles

The reaction of 3-amino-6-chloro-2-mercaptopyridine with ortho-substituted phenacyl halides has been investigated. Two types of intermediate compounds have been isolated: 3-amino-6-chloro-2-(phenacylthio)pyridines and 2-aryl-2-hydroxy-1,2-dihydro-3H-pyrido[2,3-b][1,4]thiazines. Boiling 3-amino-6-chloro-2-mercaptopyridine with ortho-substituted phenacyl halides in ethanol has given 2-aryl-3H-pyrido[2,3-b][1,4]thiazines.For Communication XXVII, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1262–1265, September, 1973. Original article submitted March 15, 1972,     

Synthesis of carbon-, phosphorus-, and sulfur-labeled ethyleneimides of phosphoric and thiophosphoric acids

A method is proposed for the preparation of¹⁴C-1,2-ethyleneimine from¹⁴C-1,2-dibromoethane.¹⁴C-Dipine (¹⁴C-1,4-piperazinediylbis [bis (1-aziridinyl)phosphine oxide]) (labeled ethylene rings),³²P-thiodipine, and³⁵S-thiodipine were synthesized.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 784–786, June, 1975.     

Investigation of nitrogen- and sulfur-containing heterocycles

Catalytic hydrogenation of cyanoacetyl-, -cyanopropionyl-, and cyanobutyrylurethanes in aqueous media in the presence of Raney nickel and the hydrochlorides of o- and p-toluidines, o- and p-alkoxyphenylamines, p-aminoacetophenone, ethyl p-aminobenzoate, and ethyl p-aminophenylacetate, and in the presence of sodium p-aminosalicylate and acetic acid gave the corresponding -arylaminoacryloyl(or -alkylacryloyl)urethanes, which were converted, without isolation in the pure state, to 1-aryl- and 1-aryl-5-alkyluracils by heating in dilute alkali solutions.See [1] for communication XXV.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1280–1282, September, 1974.