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排序方式: 共有244条查询结果,搜索用时 93 毫秒
41.
Jiawang Liu Ji Yang Francesco Ferretti Ralf Jackstell Matthias Beller 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(14):4738-4742
The first catalyst for the alkoxycarbonylation of gem‐difluoroalkenes is described. This novel catalytic transformation proceeds in the presence of Pd(acac)2/1,2‐bis((di‐tert‐butylphosphan‐yl)methyl)benzene (btbpx) ( L4 ) and allows for an efficient and straightforward access to a range of difluoromethylated esters in high yields and regioselectivities. The synthetic utility of the protocol is showcased in the practical synthesis of a Cyclandelate analogue using this methodology as the key step. 相似文献
42.
43.
A column‐switching HPLC‐MS/MS method for mucopolysaccharidosis type I analysis in a multiplex assay for the simultaneous newborn screening of six lysosomal storage disorders 下载免费PDF全文
Antonina Gucciardi Elisa Legnini Iole Maria Di Gangi Carlo Corbetta Rosella Tomanin Maurizio Scarpa Giuseppe Giordano 《Biomedical chromatography : BMC》2014,28(8):1131-1139
Lysosomal storage disorders comprise a group of rare genetic diseases in which a deficit of specific hydrolases leads to the storage of undegraded substrates in lysosomes. Impaired enzyme activities can be assessed by MS/MS quantification of the reaction products obtained after incubation with specific substrates. In this study, a column‐switching HPLC‐MS/MS method for multiplex screening in dried blood spot of the lysosomal enzymes activities was developed. Mucopolysaccharidosis type I, Fabry, Gaucher, Krabbe, Niemann–Pick A/B and Pompe diseases were simultaneously assayed. Dried blood spots were incubated with substrates and internal standards; thereafter, supernatants were collected with minor manipulations. Samples were injected, trapped into an online perfusion column and, by a six‐port valve, switched online through the C18 analytical column to perform separation of metabolites followed by MS/MS analysis. A total of 1136 de‐identified newborn screening samples were analyzed to determine references for enzymes activity values. As positive controls, we analyzed dried blood spots from three patients with Pompe, one with Fabry, one with Krabbe disease and two with MPS I, and in all cases the enzyme activities were below the cutoff values measured for newborns, except for an MPS I patient after successful hematopoietic stem cell transplantation. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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45.
R. E. P. Leite W. Jacob-Filho M. Saiki L. T. Grinberg R. E. L. Ferretti 《Journal of Radioanalytical and Nuclear Chemistry》2008,278(3):581-584
Neutron activation analysis was applied to assess trace element concentrations in brain tissues from normal (n = 21) and demented individuals (n = 21) of both genders aged more than 50 years. Concentrations of the elements Br, Fe, K, Na, Rb, Se and Zn were determined.
Comparisons were made between the results obtained for the hippocampus and frontal cortex tissues, as well as, those obtained
in brains of normal and demented individuals. Certified reference materials, NIST 1566b Oyster Tissue and NIST 1577b Bovine
Liver were analyzed for quality of the analytical results. 相似文献
46.
Cirilli R Ferretti R Gallinella B De Santis E Zanitti L La Torre F 《Journal of chromatography. A》2008,1177(1):105-113
The chiral resolving ability of the amylose-based Chiralpak IA chiral stationary phase towards omeprazole and other proton pump inhibitors under reversed-phase conditions was investigated. Organic modifier-buffer demonstrated to be a valid alternative elution mode with respect to conventional polar organic and normal-phases. No evidence of deterioration of performance of the enantioselective column after several multimodal cycles of elution was observed. Mobile phase composition was systematically changed in order to modulate the enantiomer elution order of set of compounds studied. A very simple method based on on-line detection of optical rotational sign during enantioselective HPLC was developed to assign the absolute configuration and enantiomeric elution order. 相似文献
47.
Marco Bortoluzzi Eleonora Ferretti Guido Pampaloni Stefano Zacchini 《Journal of Coordination Chemistry》2016,69(18):2766-2774
The complex [NbOF3(Ipr)]2, 1, was afforded in crystalline form by reaction of NbF5 with the bulky NHC ligand 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IPr) in toluene by slow contact with moisture air. The molecular structure of 1 was ascertained by X-ray diffraction, providing the first example of a dinuclear NbOF3 derivative and also a rare case of niobium compound with a monodentate NHC. A DFT investigation has shown that the Nb–C bond consists of a weak NHC to Nb σ donation, reinforced by an electrostatic contribution presumably favored by the presence of the ancillary fluoride ligands. The computed enthalpy for the dissociation of one Ipr from 1 is ca. 36 kcal mol?1. The presence of bulky 2,6-diisopropylphenyl substituents on the carbene ligand has negligible influence on the Nb–C bond, as highlighted by DFT analyses on simplified models. 相似文献
48.
Tegoni M Ferretti L Sansone F Remelli M Bertolasi V Dallavalle F 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(4):1300-1308
The solution equilibria of gamma-aminobutanehydroxamic acid (GABAha) with H+ and Cu2+ were investigated by potentiometry, titration calorimetry, spectrophotometry, NMR spectroscopy, and ESI-MS. The thermodynamic parameters of the CuII [12]metallacrown-4 obtained for GABAha were compared with those of the corresponding complexes of (S)-alpha-Alaha and beta-Alaha. The stability (-DeltaG0) sequence was beta-Alaha>alpha-Alaha>GABAha, whereas the order of formation enthalpies (-DeltaH0) was beta-Alaha>GABAha>alpha-Alaha. These data were interpreted on the basis of the dimensions of the chelate rings and the planarity of the metallamacrocycles. The CuII [12]metallacrown-4 ([12]MC-4) complex of GABAha was isolated and its crystal structure, which is the first reported for a [12]MC-4 of a gamma-aminohydroxamic acid, fully supports the structural features interpreted from the thermodynamic data. 相似文献
49.
Nora N. Nichio Mónica L. Casella Osmar A. Ferretti 《Reaction Kinetics and Catalysis Letters》1999,66(1):27-32
In this paper the activity, selectivity and mainly stability of nickel catalysts in the oxyreforming reaction are analyzed.
The catalysts were prepared employing different precursors (nickel nitrate and nickel acetylacetonate) on α-Al2O3 and α-Al2O3 modified by a layer of aluminium oxide. The catalytic sample obtained from nickel acetylacetonate on the modified support
showed the best stability. 相似文献
50.
R. Arnaldi K. Banicz K. Borer J. Castor B. Chaurand W. Chen C. Cicalò A. Colla P. Cortese S. Damjanovic A. David A. de Falco A. Devaux L. Ducroux H. En’yo J. Fargeix A. Ferretti M. Floris A. F?rster P. Force N. Guettet A. Guichard H. Gulkanyan J. Heuser M. Keil L. Kluberg Z. Li C. Louren?o J. Lozano F. Manso P. Martins A. Masoni A. Neves H. Ohnishi C. Oppedisano P. Parracho P. Pillot T. Poghosyan G. Puddu E. Radermacher P. Ramalhete P. Rosinsky E. Scomparin J. Seixas S. Serci R. Shahoyan P. Sonderegger H. J. Specht R. Tieulent A. Uras G. Usai R. Veenhof H. K. W?hri 《The European Physical Journal C - Particles and Fields》2009,64(1):1-18
The NA60 experiment has measured muon pair production in In–In collisions at 158 AGeV at the CERN SPS. This paper presents a high statistics measurement of φ→μ μ meson production. Differential spectra, yields, mass and width are measured as a function of centrality and compared to previous measurements in other colliding systems at the same energy. The width of the rapidity distribution is found to be constant as a function of centrality, compatible with previous results. The decay muon polar angle distribution is measured in several reference frames. No evidence of polarization is found as a function of transverse momentum and centrality. The analysis of the p T spectra shows that the φ has a small radial flow, implying a weak coupling to the medium. The T eff parameter measured in In–In collisions suggests that the high value observed in Pb–Pb in the kaon channel is difficult to reconcile with radial flow alone. The absolute yield is compared to results in Pb–Pb collisions: though significantly smaller than measured by NA50 in the muon channel, it is found to exceed the NA49 and CERES data in the kaon channel at any centrality. The mass and width are found to be compatible with the PDG values at any centrality and at any p T : no evidence for in-medium modifications is observed. 相似文献