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73.
Dr. Victor Zdorichenko Romain Paumier Thomas Whitmarsh-Everiss Dr. Mark Roe Prof. Brian Cox 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(5):1286-1292
Chagas disease also know as American Trypanosomiasis (AT) is a tropical parasitic disease endemic in South America, is caused by Trypanosoma cruzi, which is transmitted by the blood-sucking insect vectors called triatomine bugs. Quinoline alkaloids from the root extract of Waltheria indica are known to possess antitrypanosomal activity. Waltherione F, one of those alkaloids, was synthesised in 5 steps in 11 % overall yield. We report here the first X-ray crystallographic confirmation of the structure of Waltherione F 3 . A key step in the sequence utilised the Conrad–Limpach synthesis for the formation of the quinolin-4(1H)-one ring system. Our synthetic strategy was designed to enable the modification of the 2- and 3-positions of the scaffold, allowing the generation of a diverse library of analogues to support our on-going medicinal chemistry program that is looking for new agents to tackle this devastating disease. 相似文献
74.
This paper is the initial investigation into a new Lagrangian cell‐centered hydrodynamic scheme that is motivated by the desire for an algorithm that resists mesh imprinting and has reduced complexity. Key attributes of the new approach include multidimensional construction, the use of flux‐corrected transport (FCT) to achieve second order accuracy, automatic determination of the mesh motion through vertex fluxes, and vorticity control. Toward this end, vorticity preserving Lax–Wendroff (VPLW) type schemes for the two‐dimensional acoustic equations were analyzed and then implemented in a FCT algorithm. Here, mesh imprinting takes the form of anisotropic dispersion relationships. If the stencil for the LW methods is limited to nine points, four free parameters exist. Two parameters were fixed by insisting that no spurious vorticity be created. Dispersion analysis was used to understand how the remaining two parameters could be chosen to increase isotropy. This led to new VPLW schemes that suffer less mesh imprinting than the rotated Richtmyer method. A multidimensional, vorticity preserving FCT implementation was then sought using the most promising VPLW scheme to address the problem of spurious extrema. A well‐behaved first order scheme and a new flux limiter were devised in the process. The flux limiter is unique in that it acts on temporal changes and does not place a priori bounds on the solution. Numerical results have demonstrated that the vorticity preserving FCT scheme has comparable performance to an unsplit MUSCL‐H algorithm at high Courant numbers but with reduced mesh imprinting and superior symmetry preservation. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
75.
Dr. James E. H. Day Dr. Swee Y. Sharp Dr. Martin G. Rowlands Dr. Wynne Aherne Dr. William Lewis Dr. S. Mark Roe Dr. Chrisostomos Prodromou Prof. Dr. Laurence H. Pearl Prof. Dr. Paul Workman Prof. Dr. Christopher J. Moody 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(34):10366-10372
A series of resorcylic acid macrolactones, analogues of the natural product radicicol has been prepared by chemical synthesis, and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents. The synthesis involves acylation of an ortho‐toluic acid dianion, esterification, followed by a ring‐closing metathesis to form the macrocycle. Subsequent manipulation of the protected hydroxymethyl side chain allows access to a range of new analogues following deprotection of the two phenolic groups. Co‐crystallization of one of the new macrolactones with the N‐terminal domain of yeast Hsp90 confirms that it binds in a similar way to the natural product radicicol and to our previous synthetic analogues, but that the introduction of the additional hydroxymethyl substituent appears to result in an unexpected change in conformation of the macrocyclic ring. As a result of this conformational change, the compounds bound less favorably to Hsp90. 相似文献
76.
Aubert B Barate R Bona M Boutigny D Couderc F Karyotakis Y Lees JP Poireau V Tisserand V Zghiche A Grauges E Palano A Chen JC Qi ND Rong G Wang P Zhu YS Eigen G Ofte I Stugu B Abrams GS Battaglia M Brown DN Button-Shafer J Cahn RN Charles E Gill MS Groysman Y Jacobsen RG Kadyk JA Kerth LT Kolomensky YG Kukartsev G Lynch G Mir LM Orimoto TJ Pripstein M Roe NA Ronan MT Wenzel WA del Amo Sanchez P Barrett M Ford KE Harrison TJ Hart AJ Hawkes CM Morgan SE Watson AT Held T Koch H Lewandowski B 《Physical review letters》2006,97(20):201801
We report searches for B-meson decays to the charmless final states rhoK* and f0(980)K* with a sample of 232x10(6) BB pairs collected with the BABAR detector at the PEP-II e+e- collider. We measure in units of 10(-6) the following branching fractions, where the first error quoted is statistical and the second systematic, or upper limits are given at the 90% confidence level: B(B+-->rho0K*+)<6.1, B(B+-->rho+K*0)=9.6+/-1.7+/-1.5, B(B0-->rho-K*+)<12.0, B(B0-->rho0K*0)=5.6+/-0.9+/-1.3, B(B+-->f0(980)K*+)=5.2+/-1.2+/-0.5, and B(B0-->f0(980)K*0)<4.3. For the significant modes, we also measure the fraction of longitudinal polarization and the charge asymmetry: fL(B+-->rho+K*0)=0.52+/-0.10+/-0.04, fL(B0-->rho0K*0)=0.57+/-0.09+/-0.08, ACP(B+-->rho+K*0)=-0.01+/-0.16+/-0.02, ACP(B0-->rho0K*0)=0.09+/-0.19+/-0.02, and ACP(B+-->f0(980)K*+)=-0.34+/-0.21+/-0.03. 相似文献
77.
Measurement of branching fractions and charge asymmetries in B decays to an eta meson and a K* meson
Aubert B Bona M Boutigny D Couderc F Karyotakis Y Lees JP Poireau V Tisserand V Zghiche A Grauges E Palano A Chen JC Qi ND Rong G Wang P Zhu YS Eigen G Ofte I Stugu B Abrams GS Battaglia M Brown DN Button-Shafer J Cahn RN Charles E Gill MS Groysman Y Jacobsen RG Kadyk JA Kerth LT Kolomensky YG Kukartsev G Lynch G Mir LM Orimoto TJ Pripstein M Roe NA Ronan MT Wenzel WA del Amo Sanchez P Barrett M Ford KE Hart AJ Harrison TJ Hawkes CM Watson AT Held T Koch H Lewandowski B Pelizaeus M Peters K 《Physical review letters》2006,97(20):201802
We present measurements of branching fractions and charge asymmetries for the decays B-->etaK*, where K* indicates a spin 0, 1, or 2 Kpi system. The data sample corresponds to 344x10(6) BB pairs collected with the BABAR detector at the PEP-II asymmetric-energy e+ e- collider at SLAC. We measure the branching fractions (in units of 10(-6): B(B0-->etaK*0(892))=16.5+/-1.1+/-0.8, B(B+-->etaK*+(892))=18.9+/-1.8+/-1.3, B(B0-->eta(Kpi)0*0)=11.0+/-1.6+/-1.5, B(B+-->eta(Kpi)0*+)=18.2+/-2.6+/-2.6, B(B0-->etaK2*0(1430))=9.6+/-1.8+/-1.1, and B(B+-->etaK2*+(1430))=9.1+/-2.7+/-1.4. We also determine the charge asymmetries for all decay modes. 相似文献
78.
Caroline Roe 《Tetrahedron letters》2010,51(4):591-3550
Acid-catalysed solvolysis procedures exchange protecting groups on benzyl alcohol derivatives in the synthesis of η5 1-arylcyclohexadienyliron building blocks for alkaloid synthesis. The reaction proceeds via a carbocation intermediate which can also be intercepted by intramolecular electrophilic addition to the tricarbonyl(η4-diene)iron(0) moiety to provide a novel and high-yielding cyclisation reaction forming a 5aα-cyanomethyl-5a,8a-dihydrofluorene tricarbonyliron complex in 96% yield. 相似文献
79.
ER Badman GE Patterson JM Wells RE Santini RG Cooks 《Journal of mass spectrometry : JMS》1999,34(8):889-894
Dual-detector differential non-destructive Fourier transform detection in a quadrupole ion trap is shown to improve signal intensity and reduce noise compared with spectra recorded using a single detector. A larger area detector in each end-cap electrode is machined to fit its hyperbolic shape and so minimize field imperfections on the z-axis. Argon, acetophenone and bromobenzene spectra were recorded to allow a comparison between single- and dual-detector (differential) modes of detection and to demonstrate the improvement achieved with differential detection. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
80.
Polubarinova-Kochina's analytical differential equation methodis used to determine the pseudo-steady-state solution to problemsinvolving the freezing (solidification) of wedges of liquidwhich are initially at their fusion temperature. In particular,we consider four distinct problems for wedges which are: freezingwith the same constant boundary temperature, freezing with thesame constant boundary heat fluxes, freezing with distinct constantboundary temperatures and freezing with distinct constant fluxesat the boundaries. For the last two problems, a Heun's differentialequation with an unknown singularity is derived, which in bothcases admits a particularly elegant simple solution for thespecial case when the wedge angle is . The moving boundariesobtained are shown pictorially. 相似文献