Scaling studies and time-resolved microwave measurements on arelativistic backward-wave oscillator

A relativistic backward-wave oscillator (BWO) operating at a frequency near 8 GHz has been built. The parameters of the 60-ns electron beam driving this microwave source are varied over the ranges 0.8-1.5 MV and 2-10 kA. Several different annular cathodes for launching the electron beam are tried, varying the outer radius and shape. The axial magnetic field guiding the beam through the BWO is varied between 0.6 and 3 T. The power transfer downstream to an output waveguide is investigated as a function of the shape of the transition from the BWO to the waveguide. The scaling of the output power and frequency with these variations is discussed. Time-resolved measurements of 2-ns-long segments of the microwave output are shown. In observations of the microwave signal, it is found that the frequency shifts as the output power envelope passes through a sharp dip. It is proposed that this shift corresponds to a change in the longitudinal operating mode of the BWO     

In silico modeling of p450 substrates, inhibitors, activators, and inducers

Cytochrome P450 enzymes are the predominant mediators of phase I metabolism of exogenous small molecules. As a result of their extensive role in metabolism of xenobiotics, drug compounds, and endogenous compounds, as well as their wide tissue distribution, significant drug discovery resources are spent to avoid interacting with this class of enzymes. Here we review historical and recent in silico modeling of 7 cytochrome P450 enzymes of particular interest, specifically CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. For each we provide a brief biological background including known inhibitors, substrates, and inducers, as well as details of computational modeling efforts and advances in structural biology. We also provide similar details for 3 nuclear receptors known to regulate gene expression of these enzyme families.     

Gaussian Multiplicative Chaos for Symmetric Isotropic Matrices

Motivated by isotropic fully developed turbulence, we define a theory of symmetric matrix valued isotropic Gaussian multiplicative chaos. Our construction extends the scalar theory developed by J.P. Kahane in 1985.     

Determination of Complexed and Ionic Metal in Aqueous Solution. Determination of Stability Constants at Low Concentrations and Kinetic Studies of Complex Formation Using Accelerated Electrodeposition

Metal speciation has become one of the most important areas of concern for today's analysts. Metal complexes can be more readily assimilated by living systems than inorganic forms of the same metals. Conventional atomic absorption spectroscopy is the most widely used technique for the determination of trace metals. By using atomic absorption spectroscopy in conjunction with accelerated electroplating it is possible to distinguish between ionic metal and organically bound or complexed metals in solution.     

Heat Transfer to Truncated Cylinder in Cross-flow

The objective of this work is to provide a correlation between the heat transfer coefficient and the Nusselt Number with the flow Reynolds number for a truncated cylindrical probe in cross-flow, a configuration that has not previously been well defined. In the experiment, thermally stabilized, dry air was discharged into the test section across a heated probe that was instrumented with thermocouples and exhausted to atmosphere. Experimental data were recorded for several run conditions. A correlation between the probe heat transfer coefficient and the Reynolds number was developed with a calculated uncertainty of 1.24%.     

Observations of thermal transfer OSL signals in glacigenic quartz

The conclusions of Rhodes and Pownall (Rhodes, E.J., Pownall, L., 1994. Zeroing of the OSL signal in quartz from young glaciofluvial sediments. Radiation Measurements 23, 329–333) were somewhat discouraging for the prospects of using quartz OSL for dating glacigenic sediments, while the more detailed study of Rhodes and Bailey (Rhodes, E.J., Bailey, R.M., 1997. The effect of thermal transfer on the zeroing of the luminescence of quartz from recent glaciofluvial sediments. Quaternary Science Reviews (Quaternary Geochronology) 16, 291–298) provided more encouragement. Specifically, the latter authors were able to account for the relatively high D_e values observed for recent glacigenic (dominantly glaciofluvial) sediments in terms of an anomalously high thermal transfer effect, rather than simply insufficient bleaching prior to deposition. In other locations, the OSL of quartz from glacigenic material appears to provide reliable age estimates, and does not suffer from these effects (Owen, L.A., Richards, B., Rhodes, E.J., Cunningham, W.D., Windley, B.F., Badamgarav, J., Dorjnamjaa, D., 1998. Relic permofrost structures in the Gobi of Mongolia: age and significance. Journal of Quaternary Science 13 (16), 539–548; Richards, B.W., Owen, L.A., Rhodes, E.J., 2000. Timing of Late Quaternary glaciations in the Himalayas of northern Pakistan. Journal of Quaternary Science 15, 283–297). In this paper, laboratory bleached samples from both the above studies are remeasured, using an experimental design to correct for OSL sensitivity changes, which has some similarities to the single aliquot regenerative dose (SAR) protocol of Murray and Wintle (Murray A.S., Wintle A.G., 2000. Luminescence dating of quartz using an improved single-aliquot regenerative-dose protocol. Radiation Measurements 32, 57–73). Clear evidence of thermal transfer OSL signals, generated during the preheating procedure, is presented. Further measurements, using the full SAR protocol, demonstrate that the source of this charge is related to natural dosing. For one sample, the apparent effect is subtracted effectively by the SAR protocol. Another sample studied in detail shows a striking relationship between the thermally transferred OSL signal and the total TL observed during the ramping of the preceding preheat treatment.     

Homogenization of periodic semilinear parabolic degenerate PDEs

In this paper a second order semilinear parabolic PDE with rapidly oscillating coefficients is homogenized. The novelty of our result lies in the fact that we allow the second order part of the differential operator to be degenerate in some part of Rd${\mathbf{R}}^d$.     

Observation of quadrupole hyperfine structure in the v6 RQ3 (6) transition of 12CH335Cl

Quadrupole hyperfine structure has been observed in the v₆^RQ₃(6) transition of ¹²CH₃³⁵Cl using a stable CO₂ laser oscillating on the 9.4 μm P(26) line. By heterodyning this laser with another which is locked to the 4.3 μm fluorescence dip of the 00⁰1-00⁰ CO₂ transition, an accurate measurement of the hyperfine splittings has been made. The observed spectrum agrees, within experimental error, to the theoretical values evaluated without the need for a vibrational correction to the quadrupole interaction in the excited vibrational state. The hyperfine component closest to the center of the CO₂ P(26) transition is determined to be 5.6 ± 0.1 MHz from the P(26) line center.     

Temperature dependence of vibrational relaxation in carbon tetrachloride

The temperature dependence of vibrational relaxation in carbon tetrachloride has been investigated from near the melting point to near the boiling point. The method of spontaneous Brillouin scattering has been used to determine the hypersonic frequencies and velocities as functions of temperature. The dispersion in the velocities are then compared with theoretical predictions in order to investigate the character of the relaxation.