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21.
Jacob G. Reynolds 《Silicon Chemistry》2007,3(5):267-269
The Partial Charge Model was developed to predict the hydroxylation, polymerization, and precipitation of ions. The purpose
of this study is to evaluate the Partial Charge Model for describing the polymerization of silica in aqueous solutions. The
Partial Charge Model predicts the stability of ions and complexes based on the assumption that the stable species will have
the same electronegativity as the mean electronegativity of the solution. The silica system was chosen for model validation
because of the rare availability of self-consistent thermodynamic data on many dissolved but polymerized silicate anions,
including both linear and cyclical species. The electronegativity of each species was calculated using the Partial Charge
Model and the results were plotted against the stability constants for the ions. The silicate anions segregated into groups
on the plot based on the number of charges per silicon atom in the polymer. Plots of the log of the stability constant versus
the change in electronegativity produced a linear relationship for the silica polymers containing one negative charge per
silicon atom, which resulted in an r
2 of 0.9978. Thus, the Partial Charge Model successfully describes the thermodynamics of silica polymerization in aqueous solution
for species that are sufficiently alike, but was not accurate for all silica species. 相似文献
22.
RU Chang Bi Zbigniew Dauter Eleanor Dodson Guy Dodson Federico Gordiano Rod Hubbard Colin Reynolds 《Journal of Chemical Sciences》1983,92(4-5):473-483
Insulin modified by the removal of its 5 B chain C terminal residues is monomeric but remains substantially potent. The crystal
structures of the beef and insulin (dpi) with two molecules in the asymmetric unit has been determined by x-ray analysis. The 3-dimensional structure ofdpi proves to be generally similar to that of native molecule in 2Zn insulin. More detailed comparison reveals that the slight
differences in the two independent molecules of beefdpi are distributed uniformly throughout the structure in contrast to insulin in 2Zn insulin, where the structural changes are
concentrated in specific regions.
The loss of symmetry in thedpi crystal appears to be the inability of the A9 serine to pack effectively in the C2 cell. The efficient packing of the sheepdpi molecule whose crystal structure has also been determined and where A9 is glycine supports this conclusion. 相似文献
23.
J. A. Van Allan G. A. Reynolds J. F. Stenberg 《Journal of heterocyclic chemistry》1979,16(8):1661-1662
A general method for the preparations of pyranthiones is particularly useful for preparing substituted xanthiones which are unavailable by established procedures. Reaction of a xanthone with p-tosyl isocyanate or with trichloroacetyl isocyanate produces the corresponding imino derivatives, which upon treatment with n-butylamine followed by hydrogen sulfide gives the desired xanthione in good yield. 相似文献
24.
Using a direct position-space renormalization-group approach we study percolation clusters in the limits , wheres is the number of occupied elements in a cluster. We do this by assigning a fugacityK per cluster element; asK approaches a critical valueK
c
, the conjugate variables . All exponents along the path (K–K
c
) 0 are then related to a corresponding exponent along the paths . We calculate the exponent , which describes how the radius of ans-site cluster grows withs at the percolation threshold, in dimensionsd=2, 3. Ind=2 our numerical estimate of =0.52±0.02, obtained from extrapolation and from cell-to-cell transformation procedures, is in agreement with the best known estimates. We combine this result with previous PSRG calculations for the connectedness-length exponent , to make an indirect test of cluster-radius scaling by calculating the scaling function exponent using the relation =/. Our result for is in agreement with direct Monte-Carlo calculations of , and thus supports the cluster-radius scaling assumption. We also calculate ind=3 for both site and bond percolation, using a cell of linear sizeb=2 on the simple-cubic lattice. Although the result of such small-cell calculations are at best only approximate, they nevertheless are consistent with the most recent numerical estimates.Supported in part by grants from ARO and ONR 相似文献
25.
Gurfinkel M Thompson AB Ralston W Troy TL Moore AL Moore TA Gust JD Tatman D Reynolds JS Muggenburg B Nikula K Pandey R Mayer RH Hawrysz DJ Sevick-Muraca EM 《Photochemistry and photobiology》2000,72(1):94-102
We present in vivo fluorescent, near-infrared (NIR), reflectance images of indocyanine green (ICG) and carotene-conjugated 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide (HPPH-car) to discriminate spontaneous canine adenocarcinoma from normal mammary tissue. Following intravenous administration of 1.0 mg kg-1 ICG or 0.3 mg kg-1 HPPH-car into the canine, a 25 mW, 778 nm or 70 mW, 660 nm laser diode beam, expanded by a diverging lens to approximately 4 cm in diameter, illuminated the surface of the mammary tissue. Successfully propagating to the tissue surface, ICG or HPPH-car fluorescence generated from within the tissue was collected by an image-intensified, charge-coupled device camera fitted with an 830 or 710 nm bandpass interference filter. Upon collecting time-dependent fluorescence images at the tissue surface overlying both normal and diseased tissue volumes, and fitting these images to a pharmacokinetic model describing the uptake (wash-in) and release (wash-out) of fluorescent dye, the pharmacokinetics of fluorescent dye was spatially determined. Mapping the fluorescence intensity owing to ICG indicates that the dye acts as a blood pool or blood persistent agent, for the model parameters show no difference in the ICG uptake rates between normal and diseased tissue regions. The wash-out of ICG was delayed for up to 72 h after intravenous injection in tissue volumes associated with disease, because ICG fluorescence was still detected in the diseased tissue 72 h after injection. In contrast, HPPH-car pharmacokinetics illustrated active uptake into diseased tissues, perhaps owing to the overexpression of LDL receptors associated with the malignant cells. HPPH-car fluorescence was not discernable after 24 h. This work illustrates the ability to monitor the pharmacokinetic delivery of NIR fluorescent dyes within tissue volumes as great as 0.5-1 cm from the tissue surface in order to differentiate normal from diseased tissue volumes on the basis of parameters obtained from the pharmacokinetic models. 相似文献
26.
Simultaneous analysis of methionine- and leucine-enkephalin from rat brain: quantification by liquid chromatography-electrochemistry 总被引:1,自引:0,他引:1
This study focuses on the application of liquid chromatography with electrochemical detection (LC-ED) for the analysis of methionine-enkephalin (ME) and leucine-enkephalin (LE) extracted from rat brain regions. The high applied potentials necessary for enkephalin detection required the development of an efficient sample processing protocol. Brain extracts were processed using chromatographic mode sequencing (CMS). The decrease in electroactive interfering substances by CMS improved the chromatographic resolution of ME and LE and the electrode performance. Other qualitative and analytical methods were used to evaluate the enkephalin data obtained by LC-ED for rat brain regions. This study demonstrates that LC-ED provides both the sensitivity and specificity necessary for the analysis of enkephalins from rat brain regions. 相似文献
27.
A study of the dynamical molecular structure of a dilute polar fluid is reported, in which 13C spin-lattice relaxation times of decanol in deuterated cyclohexane are presented for the individual carbon atoms, and the results are discussed in the context of viscosity data of decanol in alkane systems. The two techniques provide complementary information about the mobility of the alcohol chains and the onset of multimer formation, which is also pertinent to the dynamics of electron solvation in the same systems. 相似文献
28.
Christopher A. Reynolds 《International journal of quantum chemistry》1995,56(6):677-687
Here, we have applied density functional methods, in combination with free energy hydration calculations, to calculate two-electron electrode potentials for quinones and naphthoquinones. While we find that the free-energy perturbation method, implemented within a molecular dynamics framework, is superior to the PM 3—SM 3 continuum method for determining free energies of hydration, the computationally less expensive PM 3—SM 3 method does perform well when there is not an internal hydrogen bond. Generally, all the density functional approaches investigated gave good energetics when applied to this problem, but the Beck '88—Vosko—Wilk—Nusair combination of functionals for the exchange-correlation energy gave the best results. The density functional results are marginally better than the Møller-Plesset second-order perturbation results. Moreover, because the results are obtained using a thermodynamic cycle which involves taking differences in total energies, the results are not too dependent on the quadrature scheme used to calculate the exchange-correlation energy. By using semiempirically optimized geometries and the PM 3—SM 3 method for determining free energies of hydration, it has been possible to calculate electrode potentials for a series of large molecules (naphthoquinones) to within about 30 mV of experiment. This result is extremely encouraging and shows that density functional methods offer great promise in the design of redox-active molecules such as bioreductive anticancer agents. © 1995 John Wiley & Sons, Inc. 相似文献
29.
Kryatov SV Chavez FA Reynolds AM Rybak-Akimova EV Que L Tolman WB 《Inorganic chemistry》2004,43(6):2141-2150
Dioxygen activation by enzymes such as methane monooxygenase, ribonucleotide reductase, and fatty acid desaturases occurs at a nonheme diiron active site supported by two histidines and four carboxylates, typically involving a (peroxo)diiron(III,III) intermediate in an early step of the catalytic cycle. Biomimetic tetracarboxylatodiiron(II,II) complexes with the familiar "paddlewheel" topology comprising sterically bulky o-dixylylbenzoate ligands with pyridine, 1-methylimidazole, or THF at apical sites readily react with O(2) to afford thermally labile peroxo intermediates that can be trapped and characterized spectroscopically at low temperatures (193 K). Cryogenic stopped-flow kinetic analysis of O(2) adduct formation carried out for the three complexes reveals that dioxygen binds to the diiron(II,II) center with concentration dependences and activation parameters indicative of a direct associative pathway. The pyridine and 1-methylimidazole intermediates decay by self-decomposition. However, the THF intermediate decays much faster by oxygen transfer to added PPh(3), the kinetics of which has been studied with double mixing experiments in a cryogenic stopped-flow apparatus. The results show that the decay of the THF intermediate is kinetically controlled by the dissociation of a THF ligand, a conclusion supported by the observation of saturation kinetic behavior with respect to PPh(3), inhibition by added THF, and invariant saturation rate constants for the oxidation of various phosphines. It is proposed that the proximity of the reducing substrate to the peroxide ligand on the diiron coordination sphere facilitates the oxygen-atom transfer. This unique investigation of the reaction of an O(2) adduct of a biomimetic tetracarboxylatodiiron(II,II) complex provides a synthetic precedent for understanding the electrophilic reactivity of like adducts in the active sties of nonheme diiron enzymes. 相似文献
30.
James C. Thompson A.P.Gerald Wright William F. Reynolds 《Journal of fluorine chemistry》1981,17(6):509-529
Consideration of 19F-19F and 29Si-19F coupling constants in a series of organosilicon derivatives containing SiF2 and Si2F4 units reveals a number of trends which are useful for structural and stereochemical assignments. For example the vicinal 19F-19F coupling constants in a number of CSiF2SiF2C- derivatives (including straight chain compounds, disilacyclobutanes and disilacyclohexanes) show an apparent linear dependence on dihedral angle, varying in magnitude from near zero for small values of φ up to ca. 19 Hz for φ ~ 180°. This is particularly useful for stereochemical assignments [1,2]. In addition 29Si-19F coupling constants appear to fall in quite distinct ranges (1JSiF > 300 Hz, 29 Hz < 2JSiF < 55 Hz, 3JSiF < 10 Hz). This is quite useful for structural assignments [1,6]. Reaction of SiF2 with 1,3-cyclohexadiene gives two new silicon fluorine compounds: a disilabicyclo[2,2,2]octene and an HSi2F5-substituted cyclohexadiene. 相似文献