基于超高效液相色谱-紫外检测定量指纹图谱结合化学模式识别的复方金钱草颗粒质量评价

复方金钱草颗粒具有利尿、抑制泌尿系结石形成、抗炎、抗氧化作用,且具有较大的市场需求。因此,采用超高效液相色谱-紫外检测(UPLC-UV)法建立定量指纹图谱,并结合化学模式识别技术对不同年份的复方金钱草颗粒进行质量评价,可为其质量控制提供依据。采用聚类分析(HCA)和主成分分析(PCA)等化学模式识别技术对35批复方金钱草颗粒样品的指纹图谱数据进行分析,筛选出质量差异标志物芒果苷和异芒果苷,并对二者进行含量测定。在复方金钱草颗粒指纹图谱中共指认出12个共有峰,且35批样品的相似度均在0.952以上。在HCA中,将35批样品分为了两类,其中2018年和2019年的样品为一类,2020年和2021年的样品为一类。此外,PCA结果显示了与聚类分析相同的聚类趋势。在此基础上,进一步通过正交偏最小二乘法分析 (OPLS-DA)筛选出了导致2018年、2019年与2020年、2021年的样品产生差异的差异标志物芒果苷和异芒果苷。以两个差异标志物芒果苷和异芒果苷为指标进行含量测定,结果显示色谱峰的分离度良好,线性关系良好,平均加标回收率分别为101.7%~105.6%和103.4%~105.5%,且相对标准偏差(RSD)均低于1.43%。在35批样品中,2020年、2021年的样品与2018年、2019年的样品相比,芒果苷与异芒果苷含量更高且波动范围更小。该研究建立了准确、可靠的复方金钱草颗粒质控方法,实现了对不同年份的复方金钱草颗粒样品合理、有效的质量评价,可为建立更系统、更全面的质量控制标准提供借鉴与参考。     

Bochner-Martinelli Formula for Higher Spin Operators of Several R6 Variables*

The higher spin operator of several R⁶ variables is an analogue of the ■-operator in theory of several complex variables.The higher spin representation of so₆(C)is ⊙^kC⁴ and the higher spin operator D_k acts on ⊙^kC⁴-valued functions.In this paper,the authors establish the Bochner-Martinelli formula for higher spin operator D_k of several R⁶variables.The embedding of R⁶ⁿ into the space of co...     

Reaction of 1,4-bis(trimethylsilyl)-2-butene with aromatic aldehydes catalyzed by TiCl4: an approach to (1-vinylallyl)benzene type derivatives

1,4-bis(Trimethylsilyl)-2-butene 1 can react with alkyl and aromatic aldehydes in the presence of titanium tetrachloride to give α-(trimethylsilyl)methyl homoallylic alcohols and (1-vinylallyl)benzene type compounds in poor to good yield according to the related position of each substituents present on the aromatic ring. In the last case, the reaction involves a type electrophilic substitution of 1,4-bis(trimethylsilyl)-2-butene by aromatic aldehydes activated by TiCl₄, followed by a 1,2-migration of a vinyl group.     

Fractal Dimension of Random Attractors for Non-autonomous Fractional Stochastic Reaction-diffusion Equations

This paper dealswith non-autonomous fractional stochastic reaction-diffusion equations driven by multiplicative noise with s ∈ (0,1). We first present some conditions for estimating the boundedness of fractal dimension of a random invariant set. Then we establish the existence and uniqueness of tempered pullback random attractors. Finally, the finiteness of fractal dimension of the random attractors is proved.     

cis-3-芳脲基-2-苯基-2-氧代萘并[1,2-d]-1,2-氧膦杂环戊烷合成

利用2-羟基-1-萘甲醛、芳基脲、苯基二氯化膦作为起始原料,在无水甲苯中反应合成cis-3-芳脲基-2-苯基-2-氧代萘并[1,2-d]-1,2-氧膦杂环戊烷.产物结构经IR,1HNMR,31PNMR和元素分析等进行了表征.     

关于概率空间与次线性期望空间中的随机变量一致可积性的一个注记（英文）

在这篇注记中我们讨论随机变量的一致可积性.在概率空间中,我们引进了随机变量一致可积性的两个新的定义,并证明了他们与经典定义等价.在次线性期望空间中,我们给出了随机变量一致可积性的德拉瓦利普桑准则,并作了一些其它讨论.     

不含4-圈和5-圈的平面图的非正常2-染色的一个新结果

设d_1,d_2,···,d_k是k个非负整数,若图G=(V,E)的顶点集V能被剖分成k个子集V_1,V_2,···,V_k,使得对任意的i=1,···,k,V_i的点导出子图G[Vi]的最大度至多为di,则称图G是(d_1,d_2,···,d_k)-可染的,本文证明了既不含4-圈又不含5-圈的平面图是(9,9)-可染的.     

加速溶剂萃取-超高效液相色谱-串联质谱法测定茶叶中拟除虫菊酯类农药残留

建立了加速溶剂萃取（ASE）-超高效液相色谱（UPLC）-串联质谱法（MS/MS）测定茶叶中拟除虫菊酯类农药残留的方法。ASE萃取温度为80 ℃，萃取压力为10.34 MPa，以正己烷-丙酮（2∶1，v/v）为溶剂静态萃取5 min，循环一次。萃取液浓缩后经GCB/NH₂-Florisil柱净化，UPLC分离，MS/MS正离子扫描（ESI⁺）、多反应离子监测（MRM）模式进行分析，外标法定量。线性回归分析表明：10种拟除虫菊酯的浓度与其峰面积的线性关系显著，相关系数（r）均不小于0.9995，检出限（LOD）在0.5~5.0 μg/kg之间，定量限（LOQ）在1.6~16.6 μg/kg之间；在定量限、0.4 mg/kg以及最高残留限量（MRL，无MRL的加入1 mg/kg）3个水平进行添加回收试验（n=7），回收率为68.7%~103.8%，RSD为0.8%~13.2%。该方法前处理简单，耗时短，灵敏度和准确度高，可满足茶叶中痕量拟除虫菊酯类农药残留测定的要求。     

Geometric meanings of the parameters on rational conic segments

Using algebraic and geometric methods,functional relationships between a point on a conic segment and its corresponding parameter are derived when the conic segment is presented by a rational quadratic or cubic Bézier curve.That is,the inverse mappings of the mappings represented by the expressions of rational conic segments are given.These formulae relate some triangular areas or some angles,determined by the selected point on the curve and the control points of the curve,as well as by the weights of the rational Bézier curve.Also,the relationship can be expressed by the corresponding parametric angles of the selected point and two endpoints on the conic segment,as well as by the weights of the rational Bézier curve.These results are greatly useful for optimal parametrization,reparametrization,etc.,of rational Bézier curves and surfaces.