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排序方式: 共有311条查询结果,搜索用时 429 毫秒
61.
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63.
H. Mühe Mc. Candless E. Valenta Utz Wilh Vaubel B. Ahlström O. Aschan J. Kondakow J. Schindelmeiser R. Böhme H. Herzfeld J. E. Teeple R. Adan J. Marcusson Darmois H. Wolff C. Piest R. Marcille EA. Parry M. Adams H. W. Fosse K. Ihnatowzcz 《Analytical and bioanalytical chemistry》1917,56(10-11):541-560
64.
Parry MJ Alakoskela JM Khandelia H Kumar SA Jäättelä M Mahalka AK Kinnunen PK 《Journal of the American Chemical Society》2008,130(39):12953-12960
Siramesine (SRM) is a sigma-2 receptor agonist which has been recently shown to inhibit growth of cancer cells. Fluorescence spectroscopy experiments revealed two distinct binding sites for this drug in phospholipid membranes. More specifically, acidic phospholipids retain siramesine on the bilayer surface due to a high-affinity interaction, reaching saturation at an apparent 1:1 drug-acidic phospholipid stoichiometry, where after the drug penetrates into the hydrocarbon core of the membrane. This behavior was confirmed using Langmuir films. Of the anionic phospholipids, the highest affinity, comparable to the affinities for the binding of small molecule ligands to proteins, was measured for phosphatidic acid (PA, mole fraction of X(PA) = 0.2 in phosphatidylcholine vesicles), yielding a molecular partition coefficient of 240 +/- 80 x 10(6). An MD simulation on the siramesine:PA interaction was in agreement with the above data. Taking into account the key role of PA as a signaling molecule promoting cell growth our results suggest a new paradigm for the development of anticancer drugs, viz. design of small molecules specifically scavenging phospholipids involved in the signaling cascades controlling cell behavior. 相似文献
65.
J. Timár J. Gizon A. Gizon L. Zolnai B.M. Nyakó G. Căta-Danil D. Bucurescu A.J. Boston D.T. Joss E.S. Paul A.T. Semple N.J. O'Brien C.M. Parry A.V. Afanasjev I. Ragnarsson 《The European Physical Journal A - Hadrons and Nuclei》1999,4(1):11-15
High spin states of 101Rh have been populated using the reaction 70Zn+36S at 130 MeV. γ-rays were detected with the EUROGAM2 array. New high-spin bands have been observed in this nucleus up to 45/2−, 57/2− and 65/2+ states. They have been interpreted using the Nilsson-Strutinsky cranking formalism as terminating configurations. Two of
the bands were observed up to the predicted terminating states which are built up from g9/2 protons as well as d5/2, g7/2 and h11/2 neutrons relative to a 90Zr core.
Received: 30 October 1998 相似文献
66.
KM Varier AM Vinodkumar NVSV Prasad PV Madhusudhana Rao DL Sastry Lagy T Baby MC Radhakrishna NG Puttaswamy JJ Das P Sugathan N Madhavan AK Sinha DO Kataria 《Pramana》1999,53(3):529-533
Large enhancements have been observed in the sub-barrier fusion cross sections for Ti+Ni systems in our previous studies.
Coupled channel calculations incorporating couplings to 2+ and 3− states failed to explain these enhancements completely. A possibilty of transfer channels contributing to the residual enhancements
had been suggested. In order to investigate the role of relevant transfer channels, measurements of one- and two-nucleon transfer
were carried out for 46,48Ti+61Ni systems. The present paper gives the results of these studies. 相似文献
67.
DuPont is using biotechnology to make chemical compounds and materials, especially polymers and polymer intermediates ‐ demonstrating that biotechnology can lead to more effective and productive manufacturing processes for traditional chemical businesses as well as pharmaceuticals, agricultural products, and new products for improved nutrition and health. 相似文献
68.
We outline mathematical methods which seem to be necessary in order to discuss crystal structures with non-constant dislocation density tensor (ddt) in some generality. It is known that, if the ddt is constant (in space), then material points can be identified with elements of a certain Lie group, with group operation determined in terms of the ddt—the dimension of the Lie group equals that of the ambient space in which the body resides, in that case. When the ddt is non-constant, there is also a relevant Lie group (given technical assumptions), but the dimension of the group is strictly greater than that of the ambient space. The group acts on the set of material points, and there is a non-trivial isotropy group associated with the group action. We introduce and discuss the requisite mathematical apparatus in the context of Davini’s model of defective crystals, and focus on a particular case where the ddt is such that a three dimensional Lie group acts on a two dimensional crystal state—this allows us to construct corresponding discrete structures too. 相似文献
69.
The binding potential for wetting near planes, spheres, and cylinders in systems with short-ranged forces is shown to have a universal geometrical structure. This arises from the nonlocal nature of the interfacial interactions and is exactly described by a recently proposed binding potential functional, which provides a systematic framework for studying wetting at arbitrarily shaped substrates. The corrections to the equilibrium wetting layer thickness induced by nonlocality are comparable to those arising from a Tolman length and lead to diverging terms in the total mass adsorption. 相似文献
70.
Säily VM Ryhänen SJ Lankinen H Luciani P Mancini G Parry MJ Kinnunen PK 《Langmuir : the ACS journal of surfaces and colloids》2006,22(3):956-962
The properties of a novel disulfide-bond-containing gemini surfactant bis[N,N-dimethyl-N-hexadecyl-N-(2-mercaptoethyl)ammonium bromide] disulfide (DSP) were studied using a Langmuir balance, supported monolayers, differential scanning calorimetry, giant vesicles, and LUVs. In 150 mM NaCl the cmc for DSP was 7.5 microM whereas that of the monomer N,N-dimethyl-N-hexadecyl-N-(2-mercaptoethyl)ammonium bromide (MSP) was 12.1 microM. Both surfactants exhibited single endotherms upon DSC, with peak temperatures Tm at 21.7 and 20.1 degrees C for DSP and MSP, respectively. The endotherm for MSP was significantly broader indicating less cooperative melting. Both in monolayers and in vesicles reductive cleavage of the disulfide bond of DSP could be obtained by glutathione (GSH). For Langmuir films of DSP the addition of GSH into the subphase led to a decrease in surface pressure pi as well as surface dipole potential psi. Although the cleavage by GSH was significantly slower in the presence of a charge saturating concentration of DNA, it did not prevent the reaction. The resulting monomers detached from supported monolayers, leading to loss of affinity of the surface for DNA. Disruption of giant vesicles containing DSP within approximately 30 s following a local injection of GSH was observed, revealing membrane destabilization. 相似文献