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11.
Structural and Dynamic Characterization of the Molecular Hub Early Region 1A (E1A) from Human Adenovirus 下载免费PDF全文
Marcela Oliveira Nogueira Michele Salvi Dr. Talita Duarte Pagani Prof. Isabella C. Felli Prof. Roberta Pierattelli 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(37):13010-13013
The small‐DNA human adenovirus encodes one of the most versatile molecular hubs, the E1A protein. This protein is essential for productive viral infection in human cells and a vast amount of biologically relevant data are available on its interactions with host proteins. Up to now, however, no high‐resolution structural and dynamic information on E1A is available despite its important biological role. Among the different spliced variants of E1A, two are expressed at high level in the early stage of infection. These are 243 and 289 residues isoforms. Herein, we present their NMR characterization, showing that they are both highly disordered, but also demonstrate a certain heterogeneous behavior in terms of structural and dynamic properties. Furthermore, we present the characterization of the isolated domain of the longer variant, known as CR3. This study opens the way to understanding at the molecular level how E1A functions. 相似文献
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Meccanica - This paper intends to establish a unified theory of structures based on the micropolar elasticity (ME). ME allows taking into consideration the microstructure of the material, through... 相似文献
14.
Schmidt KS Filippov DV Meeuwenoord NJ van Der Marel GA van Boom JH Lippert B Reedijk J 《Angewandte Chemie (International ed. in English)》2000,39(2):375-377
Cross-linking ability is possible with the oligonucleotide-tethered, monofunctional trans-Pt(II) complex shown. It was synthesized by a novel solid-phase approach comprising conjugation of immobilized tetrathymidylic acid with a trans-a(2)Pt(II) building unit, ammonolysis, and transformation of the resulting complex (R=1-N-cyclohexylmethylthyminate) into the chloro derivative (R=Cl). a=NH(2)CH(3), T=thymine. 相似文献
15.
Abbotto A Beverina L Bozio R Facchetti A Ferrante C Pagani GA Pedron D Signorini R 《Chemical communications (Cambridge, England)》2003,(17):2144-2145
The first examples of heterocycle-based multi-branched dyes with efficient two-photon absorption (TPA) activity are reported; the novel chromophores exhibit large TPA cross sections (as high as 1600 x 10(-50) cm4 s photon(-1) molecule(-1), measured with 150 fs laser pulses at 800 nm); a strong cooperative enhancement in the branched systems with respect to the one-dimensional sub-units is found. 相似文献
16.
Abbotto A Beverina L Bozio R Facchetti A Ferrante C Pagani GA Pedron D Signorini R 《Organic letters》2002,4(9):1495-1498
[structure: see text]. The synthesis and nonlinear optical characterization of two novel heteroaromatic-based chromophores is described. The new dyes present an A-pi-D-pi-A general framework, where A is a pi-deficient heteroaromatic ring (pyridine, quinoline, benzothiazole) and D a pi-excessive pyrrolyl moiety. Both systems exhibit large two-photon absorption (TPA) values in the femtoseconds regime (TPA cross section as high as 150 x 10(-50) cm(4) s photon(-1) molecule(-1) with 150 fs laser pulses). Their TPA-based optical limiting activity is also shown. 相似文献
17.
Riccardo Ricceri Alessandro Abbotto Antonio Facchetti Daniela Grando Gabriella Gabrielli Giorgio A. Pagani 《Colloids and surfaces. A, Physicochemical and engineering aspects》1999,150(1-3):289-296
We report on Langmuir-Blodgett (LB) films characterization of 4-[5-dicyanomethanido)thien-2-y1]-N-(n-hexadecyl)pyridinium (C16H33-PDCNT), and 1-(N-(n-hexadecy]-4-pyridinio)-2-[5-(dicyanomethanido)thien-2-yl]ethene (C16H33-PDCNTE); LB films of the pure compounds and of the mixtures of the two compounds were prepared at 291 K: UV-vis investigation revealed the presence of photobleachable absorption bands, the ones at about 530 nm and 640 nm were due to charge transfer transitions of the monomer of C16H33-PDCNT and C16H33-PDCNTE, respectively; the sharp, photobleachable ones shifted to shorter wavelengths were due to H-aggregates of the two compounds. By changing the molar ratios of the two compounds in the mixtures and in other cases by annealing the LB films, the absorption maxima of the sharp, photobleachable bands due to H-aggregates could be tuned in the range 415–467 nm. These LB films are thus very promising in view of optical data storage applications. 相似文献
18.
Carlo Marchioro Enrico Pagani H. Neunzert 《Mathematical Methods in the Applied Sciences》1986,8(1):328-344
We prove that two initially concentrated vortices with opposite vorticity of an incompressible ideal fluid moving in a two-dimensional bounded domain, remain concentrated during the time. The motion of their centers converges to the solution of the point vortex model with the corresponding initial conditions. 相似文献
19.
Dr. Rubén Orihuela Freddy Monteiro Dr. Ayelén Pagani Prof. Mercè Capdevila Prof. Sílvia Atrian 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(41):12363-12372
It has previously been shown that recombinant synthesis, under metal‐supplemented conditions, of diverse metallothioneins (MTs) results in the recovery of a subpopulation of S2?‐containing complexes in addition to the S2?‐devoid canonical metal–MT species. Further significance of this finding has remained veiled by the possibility of it being a mere consequence of synthesis in a heterologous bacterial system. Herein, we present definitive evidence that S2? ligands are also constituents of native metal–MT complexes. Because, although practically universal, the highest S2? content is incorporated by copper‐thioneins when coordinating divalent metal ions, we adapted the Saccharomyces cerevisiae Cup1 protein, which is the most paradigmatic copper‐thionein, as an experimental model. Most significantly, native Cd–Cup1 complexes were purified and fully spectroscopically and spectrometrically characterized from the 301N mutant yeast strain, which allows Cup1 synthesis even in the absence of copper. These results undoubtedly revealed the presence of a Cd–S2?–Cup1 species in native preparations, which were only recovered when carefully avoiding the use of ion‐exchange chromatography in the purification protocol. Furthermore, complete analysis of recombinant (Escherichia coli) Zn–Cup1, Cd–Cup1, and Cu–Cup1 and those complexes that result from Zn/Cd and Zn/Cu replacements in vitro and acidification/renaturalization processes yielded a comprehensive and comparative overview of the metal‐binding abilities of Cup1. Overall, we consider the main conclusions of this study to go beyond the mere study of the particular Cup1 MT, so that they should be considered to delineate a new point of view on the interaction between copper‐thioneins and divalent metal ions, still an unexplored aspect in MT research. 相似文献
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